1. Pertussis Lecture topics by Kenneth Todar of the University of Wisconsin Department of Bacteriology. With introduction, pathogenesis, colonization, the toxins, regulation of virulence factors, and vaccine. http://www.bact.wisc.edu/Bact330/lecturebpertussis

Bacteriology at UW-Madison Bacteriology 330 Home Page Bordetella pertussis and Whooping Cough Bordetella pertussis Whooping cough pertussis ) is caused by the bacterium Bordetella pertussis. B. pertussis is a very small Gram-negative aerobic coccobacillus that appears singly or in pairs. Its metabolism is respiratory, never fermentative, and taxonomically, Bordetella is placed among the "Gram-negative Aerobic Rods and Cocci" in Bergey's Manual. Bordetella is not assigned to any family. The bacteria are nutritonally fastidious and are usually cultivated on rich media supplemented with blood. They can be grown in synthetic medium, however, which contains buffer, salts, an amino acid energy source, and growth factors such as nicotinamide, for which there is a strict requirement. Even on blood agar the organism grows slowly and requires 3-6 days to form pinpoint colonies. Bordetella pertussis colonizes the cilia of the mammalian respiratory epithelium (Figure 1). Generally, it is thought that B. pertussis

2. Pediatric Database - Pertussis Describes the clinical aspects of whooping cough including its epidemiology and pathogenesis. Summarizes treatment options. Last Updated 2/22/94. pertussis (WHOOPING COUGH). DEFINITION http://www.icondata.com/health/pedbase/files/PERTUSSI.htm

Pediatric Database (PEDBASE) Discipline: RES Last Updated: 2/22/94 PERTUSSIS (WHOOPING COUGH) DEFINITION: An acute bacterial infection of the lower respiratory tract characterized by a paroxysmal cough. EPIDEMIOLOGY: prevalence: 10/100,000 age of onset: all, but 50% before 2 years and 35% before 6 months of age risk factors: endemic and epidemic every 2-4 years non-immunized children history of contact PATHOGENESIS: 1. Etiology 1. Bacterial Pathogen Bordetella pertussis (gram negative bacilli) 2. Pathogenesis spread: airborne droplet incubation period: 6 to 20 days and usually 7-10 days infectivity: 1 week before the onset of the paroxysmal cough and 3 weeks after (maximal in Catarrhal Stage) duration of illness: 6-10 weeks in uncomplicated cases a whooping cough syndrome may also be caused by: Bordetella bronchiseptica - CMV Chlamydia trachomatis CLINICAL FEATURES: 1. Catarrhal Stage lasts 7-10 days prodrome of mild upper respiratory tract symptoms: anorexia and listlessness cough - hacking and nocturnal coryza and rhinorrhea inflammed mucous membranes insidious and most contagious stage 2. Paroxysmal Stage

3. Pertussis Facts Find out how this condition also known as whooping cough - spreads and who is at risk. Read about treatment and vaccination. pertussis. pertussis per-TUS-is is a bacterial infection of the respiratory tract. http://www.astdhpphe.org/infect/per.html

Pertussis Pertussis is spread easily from person to person. People get pertussis by breathing in airborne droplets expelled from the nose or throat of an infected person. Despite an effective vaccine, pertussis continues to cause serious illness and death. Young children are most at risk for pertussis, but the disease is increasing in adolescents and adults. What is pertussis? Pertussis is a very contagious disease of the mucous membranes that line the air passages. It is also called whooping cough. What is the infectious agent that causes pertussis? Pertussis is caused by Bordetella pertussis , a bacterium. Where is pertussis found? Pertussis occurs worldwide. Pertussis bacteria live in the mouth, nose, and throat of an infected person. How do people get pertussis? Pertussis spreads easily from person to person. People get pertussis by breathing in droplets expelled from the nose or throat of an infected person during coughing or sneezing. It is also spread by direct contact with discharges from the nose or throat of an infected person. What are the signs and symptoms of pertussis?

4. Pertussis (Whooping Cough) Fact Sheet pertussis (Whooping Cough) Fact Sheet. pertussis is a highly contagious bacterial infection that causes coughing and gagging with little or no fever. An infected person has cough episodes that may end in vomiting or cause a "whoop" sound when the http://www.metrokc.gov/health/prevcont/pertuss.htm

The Pertussis Webpage has moved to: http://www.metrokc.gov/health/prevcont/pertussis.htm You will be automatically re-directed to the new address. Please update your bookmarks. If the page doesn't refresh, click here to continue All information is general in nature and is not intended to be used as a substitute for appropriate professional advice. For more information please call (206) 296-4600 (voice/TDD). Updated: February 16, 2000, 11:37 AM Public Health Homepage Safe Food Safe Water Communicable Disease ... Search Links to external sites do not constitute endorsements by King County. By visiting this and other King County web pages, you expressly agree to be bound by terms and conditions of the site. The details.

5. The Sanger Institute B.pertussis Project performed in collaboration with Duncan Maskell and Andrew Preston of the Centre for Veterinary Category Health Conditions and Diseases Whooping Cough......Bordetella pertussis. The Sanger Institute has completed the sequencingof Bordetella pertussis, the causative agent of whooping http://www.sanger.ac.uk/Projects/B_pertussis/

6. Page Moved - Pertussis pertussis, Version en español (whooping cough). What is pertussis? pertussis, orwhooping cough, is a highly contagious disease involving the respiratory tract. http://www.health.state.ny.us/nysdoh/consumer/pert.htm

location.href="/nysdoh/communicable_diseases/en/pert.htm"; Page moved click here if your browser does not forward you to the new page. http://www.health.state.ny.us/nysdoh/communicable_diseases/en/pert.htm

7. MEDLINEplus Medical Encyclopedia: Pertussis Definition, causes, incidence, risk factors, and immunization information for whooping cough.Category Health Conditions and Diseases Whooping Cough......pertussis. to top. pertussis, also known as whooping cough, is causedby infection with the Bordetella pertussis bacteria. The infection http://www.nlm.nih.gov/medlineplus/ency/article/001561.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Pertussis Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Respiratory system overview Alternative names Return to top Whooping cough Definition Return to top Pertussis is a highly contagious bacterial disease which affects the respiratory system and produces spasms of coughing that usually end in a high-pitched sounding deep inspiration (the "whoop"). Causes, incidence, and risk factors Return to top Pertussis, also known as whooping cough, is caused by infection with the Bordetella pertussis bacteria. The infection is spread through the air by respiratory droplets from an infected person. The incubation period is usually 7 days. Whooping cough can affect people of any age. Prior to the advent of widespread immunization, the disease occurred mostly in infants and young children. Now that the majority of children are immunized before school age, a higher percentage of cases are seen among adolescents and adults. About 38% of recognized cases still occur in infants younger than 6 months of age, however. Early immunization (see childhood immunization schedule) can usually prevent the occurrence of this serious disease, which can sometimes be fatal or lead to permanent disability when it affects babies.

8. Synopsis - Guidelines For The Control Of Pertussis In Australia Synopsis of the communicable diseases intelligence technical report series number 1 endorsed by the Communicable Diseases Network of Australia and New Zealand. http://www.health.gov.au/pubhlth/strateg/communic/tech/pertus.htm

This site uses Javascript for its navigation, if you have javascript turned off please use the buttons on the left hand side of the page. Please select a topic from list... Alcohol Australia's Biosecurity Health Response Bovine Spongiform Encephalopathy (BSE) Bowel Cancer Screening Pilot Breastfeeding BreatScreen Australia Cervical Screening Program National Child Nutrition Program Communicable Diseases National Comorbidity Project Disaster Medicine Unit Environmental Health Falls Prevention for Older People Initiative Folate Food Policy Group Health Inequalities Research Collaboration (HIRC) Hepatitis C HIV/AIDS Immunise Australia Program Injury Prevention JETACAR National Drug Strategy National Illicit Drug Strategy (Tough on Drugs) National Health Strategy Papers Physical Activity Pituitary Hormone Initiatives Population Health Social Marketing Promoting Healthy Weight Tobacco SYNOPSIS Guidelines for the control of pertussis in Australia Communicable Diseases Intelligence Technical Report Series No 1 The control of pertussis in Australia report, endorsed by the Communicable Diseases Network of Australia and New Zealand, is the first in the Communicable Diseases Intelligence Technical Report Series.

9. Immunization Action Coalition - Pertussis Click here for a larger image size. Click here for the largest image size . Courtesy of World Health Organization child has pertussis difficult for him to stop coughing and to get air http://www.immunize.org/images/ca.d/ipcd1861/img0007.htm

Pertussis Image Click here for a larger image size. Click here for the largest image size Courtesy of World Health Organization child has pertussis difficult for him to stop coughing and to get air coughing spasms with a "whooping" sound that follows the cough are typical sound means child is trying to catch his breath before the next round of coughing Pertussis serious disease especially for babies most babies who get pertussis have to be hospitalized and some even die Pertussis germ lives in the mouth, nose, and throat spreads through coughing and sneezing spreads very easily from parent to child or child to child Once infected takes 5-10 days to get sick Symptoms adults usually do not get very sick children can have fever coughing severe cough with a "whooping" sound vomiting and exhaustion after severe coughing difficulty breathing Complications pneumonia seizures brain damage death Children under 7 years of age need to be vaccinated against pertussis. Photos index Home Page Immunization Action Coalition 1573 Selby Avenue St. Paul MN 55104

10. First Acellular Pertussis Vaccine Approved For Infants Article about the Food and Drug Administration's announcement on licensing the first acellular pertussis vaccine for use in infants and children two months of age and older for the primary series of immunizations. Kidsource.com http://www.kidsource.com/kidsource/content/news/infant_vaccine8_1_96.html

First Acellular Pertussis Vaccine Approved For Infants advertisement Source PR NEWSWIRE Forums Health, Safety, Nutrition and Kids Related Articles Promising Data Released On New Infant Vaccine To Prevent Middle-Ear Infections, Meningitis and Pneumonia Kids' Vaccinations Get a Little Easier Information and news releases furnished by the members of PR Newswire, who are responsible for their fact and content. WASHINGTON, July 31, 1996 The Food and Drug Administration today announced it has licensed the first acellular pertussis vaccine for use in infants and children two months of age and older for the primary series of immunizations. The vaccine protects infants against whooping cough while causing fewer side-effects than whole-cell pertussis vaccines now on the market. Currently, U.S. children receive a whole-cell pertussis vaccine in combination with diphtheria-tetanus toxoid, commonly called DTP, at 2, 4 and 6 months of age, with additional doses of either a DTP or DT vaccine with an acellular pertussis component (DTaP) at 12-18 months and before going to school. The vaccine approved today for infants is one of two DTaP vaccines already approved for children to be given as fourth and fifth doses following three DTP doses. This approval should give parents more confidence in the safety of the pertussis vaccine their infants will receive.

11. Lowell General Hospital - About LGH General information about perutissis. http://www.lowellgeneral.org/text/Pertussis.html

Welcome to LGH News >> Current (2002) News Archive 2001 ... Contacting LGH The page cannot be found The page you are looking for might have been removed, had its name changed, or is temporarily unavailable.

12. Pertussis - Common Questions Questions and answers about pertussis in children and adults. http://www.spokanecounty.org/health/CA/epi/Pertussis/common-questions.htm

INDEX INFORMATION DEPARTMENTS jlee@spokanecounty.org Spokane Regional Health Dist. Last updated: October 19, 2000 PERTUSSIS: Commonly Asked Questions April, 1997 Do adults have to worry about pertussis? Pertussis vaccine is not recommended for anyone over the age of 7 years. A healthy individual over 7 years of age is thought to be mature enough to handle pertussis without the serious complications that would be seen in an infant. How can a child who is fully immunized get pertussis? The pertussis vaccine is not completely effective in preventing pertussis. Pertussis vaccine will prevent serious complications due to pertussis infection and reduce the severity of the illness. Can you get pertussis from being around someone who was exposed? It takes significant exposure to an infected individual to become infected. It is less likely that a person would become infected by someone who was merely exposed to pertussis and is not having any symptoms. If my child has tested negative for pertussis, why does he/she still have to take medicine? If children have been significantly exposed to pertussis they may be incubating the infection, and not yet able to test positive. By treating the exposed individuals the risk of transmission to others is reduced dramatically

13. Pertussis.com pertussis.com is a tool to help healthcare providers and parents to recognizepertussis (aka whooping cough), a serious childhood disease. http://www.pertussis.com/

var javascript_version = 1.0; NAPNAP is the professional organization that advocates for children (infants through young adults) and provides leadership for Pediatric Nurse Practitioners who deliver primary health care in a variety of settings. The information contained in the pertussis.com web site should not be used as a substitute for the medical care and advice of your healthcare provider. There may be variations in treatment that your healthcare provider may recommend based on individual facts and circumstances. Pertussis.com is an educational project by the National Association of Pediatric Nurse Practitioners (NAPNAP) . Pertussis.com is made possible through an unrestricted educational grant from Aventis Pasteur If you have comments or suggestions about this site, click here.

14. Pertussis.com Reporting Guide pertussis disease is generally underreported and under-diagnosed forseveral potential reasons. Because a pertussis vaccine exists http://www.pertussis.com/repguide.html

var javascript_version = 1.0; Pertussis disease is generally under-reported and under-diagnosed for several potential reasons. Because a pertussis vaccine exists in the US, there may be a misconception that immunization has eliminated the disease. With nearly 8,000 cases reported in 2001, it is clear that awareness must be increased because pertussis is much more prevalent than is currently perceived. Public health officials rely on physicians and health care professionals (PNPs, PAs, etc.), to report the occurrence of notifiable diseases to state and local health departments. Without such data, monitoring trends or evaluating the effectiveness of intervention activities would be difficult. The Pertussis.com Reporting Guide provides healthcare professionals with links to reporting forms and/or reporting contact information for all 50 states, including the District of Columbia. State laws require that healthcare providers, physicians, and laboratories report cases of pertussis to their state health or epidemiology department. Pertussis is normally categorized as a Category 1 disease, meaning it must be reported immediately. State health departments, in turn, collect reports from physicians and healthcare providers either directly or through local health officers. The state health departments provide the number of cases reported in their state to the CDC. The CDC does not take reports of pertussis cases directly from individual healthcare providers. The data collected by the CDC is published weekly in its Morbidity and Mortality Weekly Report (MMWR).

15. Anti-immunisation Scare: The Inconvenient Facts A review and debunking of an antivaccine proponent, with information on the effects of reducing immunization rates of pertussis and measles and the false link between DTP and SIDS. http://www.skeptics.com.au/journal/anti-immune.htm

Australian Skeptics What's New Quick Tour News Site Map ... Search 'The Skeptic' Journal Back to: Home Journal Home About ... Web Anti-immunisation scare: The inconvenient facts Dr. Steve Basser (Vol 17, No 1) Introduction Over the last few years immunisation rates in Australia have fallen. As a result there have been outbreaks of the infectious diseases immunisation is designed to combat. Earlier this year there was a significant outbreak of pertussis (whooping cough) with at least three children dying from this preventable disease. There has been a lot of media attention focused on the immunisation issue, and in an attempt at ‘balanced’ reporting the views of individuals and groups who oppose immunisation have been given plenty of coverage. The most well known example of this was the ABC TV Quantum two part series aired on September 26 and October 3, 1996. The Australian Skeptics have been critical of the media in the past when they have unquestioningly given coverage to issues such as alien abductions or astrology. Can we now have our cake and eat it too? Is it reasonable to expect the media to only present the ‘immunisation is good’ message? Are there really two sides to the immunisation ‘debate’? This is the question the sceptical scientist should be asking. Perhaps the answer lies in the distinction between scientific evidence and individual opinion. There will be a number of different opinions, or beliefs, about immunisation but, as the Australian Skeptics have so often observed, believing something to be so does not necessarily make it so.

16. Pertussis - CDC Presented in Adobe Acrobat format, this article from the Center for Disease Control covers clinical features and complications of whooping cough. pertussis, or whooping cough, is an acute infectious disease caused http://www.cdc.gov/nip/publications/pink/pert.pdf

17. Communicable Disease Control, Epidemiology And Immunization Section Communicable disease information for HIV/AIDS, pertussis, influenza, tuberculosis, typhoid fever, chickenpox, and others. http://www.metrokc.gov/health/prevcont/

Communicable Disease Control, Epidemiology and Immunization Section 999 3rd Avenue, Suite 900 Seattle, WA 98104-4039 Phone: (206) 296-4774 Hours: Open Monday - Friday, 8:00 AM to 5:00 PM Click here for map Click on "Driving Directions" at right of map to generate driving directions from your location. Newsletters and publications Epi-Log Newsletter Produced monthly, the Epi-Log Newsletter contains articles about current health issues in King County, such as recent outbreaks, vaccination programs, cases of unusual infectious diseases, and background articles on new and emerging infectious diseases. Vac Scene Newsletter The Vac-Scene Newsletter is produced bi-monthly to health care providers who use publicly funded vaccines for child immunizations. The purpose of this newsletter is to give you up-to-date information that is valuable to your practice. Asian Pacific Island Poster Order Form Posters on hepatitis B prevention among Asian and Pacific Islander (API) persons available in seven languages for King County clinics. Where to get immunized in King County Public Health immunization clinic timetable and locations Community clinics in King County Affordable health care: Free or low-cost health insurance Notifiable communicable diseases in Washington State Information for health care providers in King County: HOW TO REPORT A NOTIFIABLE CONDITION IN KING COUNTY: AIDS/HIV STDs TB Other Communicable Diseases Automated 24-hour reporting line for conditions not immediately notifiable

18. Irish Vaccine Injury Campaign The group provides support to parents and families whose children reacted to the diphteriapertussis-tetanus (DPT) vaccine and suffered injuries and death in some cases as a result. http://www.irishvaccineinjury.com

19. Pertussis (Whooping Cough) Fact Sheet pertussis (Whooping Cough) Fact Sheet. pertussis is a highly contagious bacterialinfection that causes coughing and gagging with little or no fever. http://www.metrokc.gov/health/prevcont/pertussis.htm

Communicable Disease Fact Sheet Pertussis (Whooping Cough) What Is It? Symptoms Potential Complications How Is It Spread? ... "Pertussis on the rise in King County" (Nov. 21, 2002 press release) What is it? Pertussis is a highly contagious bacterial infection that causes coughing and gagging with little or no fever. An infected person has cough episodes that may end in vomiting or cause a "whoop" sound when the person tries to breathe in. Video: What pertussis looks and sounds like: www.vaccineinformation.org/video/pertuss Symptoms Symptoms appear between 6 to 21 days (average 7-10) after exposure to the bacteria. The disease starts with cold symptoms: runny nose and cough. Sometime in the first 2 weeks, episodes of severe cough develop and that can last 1 to 2 months. The person may look and feel fairly healthy between these episodes. During bouts of cough, the lips and nails may turn blue for lack of air. Vomiting may occur after severe coughing spells. During the severe coughing stage, seizures or even death can occur, particularly in an infant. Immunized school children and adults have milder symptoms than young children.

20. MEDLINEplus: Whooping Cough General/Overviews pertussis (Whooping Cough) (American Medical Association).Pictures/Diagrams pertussis (Immunization Action Coalition). http://www.nlm.nih.gov/medlineplus/whoopingcough.html

Skip navigation Other health topics: A B C D ... List of All Topics Whooping Cough Contents of this page: General/Overviews Pictures/Diagrams Prevention/Screening Research ... Children Search MEDLINE for recent research articles on Whooping Cough You may also be interested in these MEDLINEplus related pages: Childhood Immunization Cough Child and Teen Health Infections General/Overviews Pertussis (Whooping Cough) (American Medical Association) Pictures/Diagrams Pertussis (Immunization Action Coalition) Prevention/Screening Diphtheria, Tetanus, and Pertussis Vaccines (Centers for Disease Control and Prevention) Also available in: Spanish Improved Pertussis Vaccines: Enhancing Protection (National Institute of Allergy and Infectious Diseases) Newly Formulated DTaP (Diphtheria, Tetanus, and Pertussis) Vaccine Approved With Only Trace Amounts of Thimerosal (Food and Drug Administration) Preventing Whooping Cough (American Academy of Pediatrics) Research Measles and Pertussis Risk Higher for Children with Personal Exemptions From Immunizations (American Medical Association) Specific Conditions/Aspects Diphtheria, Tetanus, and Pertussis: Health Information for International Travel, 2001-2002

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