1. Immune Demyelinating PN Treatment Cyclophosphamide; Human Immune Globulin. From M. AlLoziPOEMS Thickened, dry skin Clubbing of fingers. poems syndrome 21. http://www.neuro.wustl.edu/neuromuscular/antibody/pnimdem.html

Front Search Index Links ... Patient Info CHRONIC IMMUNE POLYNEUROPATHIES: DEMYELINATING Comparative features: Demyelinating PN Treatment strategies CIDP ... GALOP syndrome GD1a antibody Motor-Sensory neuropathy Multifocal motor neuropathy MAG antibody associated neuropathy Osteosclerotic Myeloma ... Antibody testing Myelinated Axons: Segmental demyelination in Multifocal Motor Neuropathy (MMN) CHRONIC IMMUNE DEMYELINATING NEUROPATHIES COMPARATIVE FEATURES Neuropathy Clinical Features Electrophysiology Antibody M-Protein Treatment CIDP Weakness: Symmetric Onset: 1 to 80 yrs Chronic or Relapsing Motor + Sensory D Slow NCV Conduction Block Distal Latency: Long Slow F-waves Targets b -tubulin Heparan sulfate Class: IgM or IgG Frequency: 20% T-cell immunosuppression Prednisone Cyclosporine A Methotrexate HIG Plasma Exchange Multifocal CIDP Also see: CIDP variants Chronic Weakness: Asymmetric Onset: 15 to 75 yrs Motor + Sensory D Slow NCV Conduction Block Distal Latency: Long Slow F-waves T-cell immunosuppression Prednisone HIG MMN Motor only Asymmetric Onset: 25 to 60 yrs Slowly progressive Motor only Conduction Block Axonal Loss EMG: No paraspinous denervation Targets Co-GM1 or NP-9 Class: IgM Frequency: 80% HIG B-cell immunosuppression Plasma Exchange + Cyclophosphamide Rituxan Anti-MAG Distal; Symmetric

2. Treatment Of POEMS Syndrome, Mayo Clinic In Rochester, Minn. Treatment of poems syndrome at Mayo Clinic in Rochester. poems syndromeis with multiple myeloma. How is poems syndrome diagnosed? http://www.mayoclinic.org/poems-rst/

search: Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services POEMS Syndrome POEMS Syndrome Treatment Disease Characteristics Appointments Clinical Trials ... Medical Services Treatment of POEMS Syndrome at Mayo Clinic in Rochester POEMS syndrome is a very rare type of bone marrow disorder whose cause is unknown. Neither an inherited nor contagious disease, it involves an overgrowth of bone marrow cells called plasma cells. In patients with POEMS syndrome, this abnormal collection of cells produces chemicals that damage other parts of the body. Patients sometimes confuse POEMS syndrome with multiple myeloma. The symptoms and potential complications of these diseases are very different. The average expected life span is better in patients with POEMS (who may have osteosclerotic myeloma ) than it is in patients with multiple myeloma. How is POEMS syndrome diagnosed? The diagnosis is made by combining the information from a thorough history, physical examination, and blood, urine, X-ray and bone marrow tests. The overgrowth of plasma cells can often be detected by finding an abnormal protein in the blood or urine (a monoclonal protein), by an abnormality on a bone X-ray, and/or a bone marrow biopsy. POEMS is a syndrome, which means that several features must be present to make the diagnosis. Because it is so rare, the diagnosis is often missed. Initially, you may have been told that you had a nerve problem without any known cause. Or you may have been told that you have multiple myeloma, which is a type of bone marrow cancer.

3. EMedicine - POEM Syndrome : Article Excerpt By: Wingfield Rehmus, MD, MPH in the levels of a cytokine or growth factor. poems syndrome first was described by Crow in 1956 and then by Fukase http://www.emedicine.com/derm/byname/poem-syndrome.htm

(advertisement) Excerpt from POEM Syndrome Synonyms, Key Words, and Related Terms: Crow-Fukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell dyscrasia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes Please click here to view the full topic text: POEM Syndrome Background: POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes) syndrome is a rare multisystemic disease that occurs in the setting of a plasma cell dyscrasia. The pathophysiologic link between the constellation of symptoms and the underlying disease is not well understood, but the link may be related to changes in the levels of a cytokine or growth factor. POEMS syndrome first was described by Crow in 1956 and then by Fukase in 1968. The syndrome was termed Crow-Fukase (by which it is known in Japan) syndrome by Nakanishi in a study of 102 cases in Japan. In 1980, the acronym POEMS was coined by Bardwick et al based on the 5 main features of the disease, namely, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. No specific case definition for POEMS exists; however, most authors agree that patients with POEMS syndrome should have 3 or more of the 5 systems involved. The pathophysiology of the disease is not known; however, elevated levels of cytokines and growth factors have been implicated. Polyneuropathy: The polyneuropathy associated with POEMS syndrome is a bilateral symmetric disturbance. It involves both motor and sensory nerves, begins distally, and has a progressive proximal spread. Associated cranial or autonomic nerves are not involved. Both demyelination and axonal degeneration are noted.

4. Redirect Page For "/mmgrg/rst/poems.htm" poems syndrome is a very rare type of bone marrow disorder whose cause is unknown. http://www.mayo.edu/mmgrg/rst/poems.htm

The page you requested has moved to a new location. http://www.mayoclinic.org/poems-rst/ This page should automatically redirect your browser. Please update your bookmarks. File poems.htm last modified: Wednesday, 08-Jan-2003 19:00:45 CST

5. NORD - POEMS Syndrome Offers the synonyms, a general discussion and resources. http://www.stepstn.com/cgi-win/nord.exe?proc=GetDocument&rectype=0&recnu

6. S000516c - POEMS Syndrome 5/16/00 (Del Rio) Group Tuesday Interns RE A 24 year old African American fe male with undiagnosed fever and renal insufficiency. Question What is the poems syndrome? 1 20143022 LINK TO FULLTEXT 54(3)7723, 2000 Feb 8. http://www.emory.edu/WHSCL/grady/amreport/litsrch99/s000516c.html

[litsrch99/page_header.html] POEMS Syndrome 5/16/00 (Del Rio) Group: Tuesday Interns RE: A 24 year old African American fe male with undiagnosed fever and renal insufficiency. Question: What is the POEMS syndrome? Neurology. 54(3):772-3, 2000 Feb 8. POEMS syndrome with necrotizing vasculitis: a novel feature of vascular abnormalities. Journal of Cutaneous Pathology. 27(2):87-92, 2000 Feb. Glomeruloid hemangioma in POEMS syndrome shows two different immunophenotypic endothelial cells. American Journal of Dermatopathology. 21(6):567-70, 1999 Dec. POEMS syndrome with xanthomatous cells. Polyneuropathy Organomegaly Endocrinopathy M-protein Skin changes. Nephrology, Dialysis, Transplantation. 14(10):2370-8, 1999 Oct. A spectrum of clinicopathological features of nephropathy associated with POEMS syndrome. Chest. 115(6):1740-2, 1999 Jun. Pulmonary manifestations of POEMS syndrome: case report and literature review. Clinical Infectious Diseases. 28(3):678-9, 1999 Mar. Antibodies to human herpesvirus 8 in POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin: changes) syndrome with multicentric Castleman's disease.

7. Demyelinating Neuropathies poems syndrome Polyneuropathy Organomegaly Endocrinopathy or Edema MproteinSkin changes; Perineuritis; IgM anti-GD1b antibody syndrome Occasional. Toxins. http://www.neuro.wustl.edu/neuromuscular/nother/myelin.html

Front Search Index Links ... Patient Info NEUROPATHIES WITH ABNORMAL MYELINATION Clinical types Immune Toxins Drugs Hereditary ... Myelin Proteins J Kwon Immune Acute Chronic Chronic Immune Demyelinating Polyneuropathy (CIDP) Multifocal CIDP Multifocal Motor Neuropathy (MMN) Anti-MAG Syndrome GALOP Syndrome Anti-Sulfatide Antibody Syndrome (with serum M-protein Anti-GM2 antibody syndrome POEMS Syndrome P olyneuropathy O rganomegaly E ndocrinopathy or Edema M -protein S kin changes Perineuritis IgM anti-GD1b antibody syndrome : Occasional Toxins Diphtheria Buckthorn Hexachlorophene Sodium Cyanate Tellurium Drugs Predominantly demyelinating Chloroquine FK506 (Tacrolimus) Perhexiline Procainamide ... Farber's disease (Lipogranulomatosis) Dominant: IA IB III HNPP ... Thermosensitive Recessive: III (Dejerine-Sottas) 4D (LOM) HMSN-R CNS X-linked: IX Krabbe Metachromatic Leukodystrophy Niemann-Pick ... Pelizaeus-Merzbacher (PLP) Refsum Prion protein (PrP27-30): Glu200Lys mutation Creutzfeld-Jakob disease Mouse model: Prion over expression Salla disease Tenascin-XA Uneven packing of peripheral myelin sheaths Ehlers-Danlos phenotype Metabolic (unusual) Diabetes (? due to concurrent

8. Rd.com: Health Channel A description of poems syndrome with further resources and a look at the alternative names. http://www.readersdigesthealth.com/kbase/nord/nord789.htm

Welcome! Click here to register now. Privacy Policy Health Money ... rd.com Home Page SEARCH All of RD.com RDstore only REGISTER now to get FREE info-packed e-newsletters! OTHER RD SITES Choose a Site Easy Ways to Catch More ZZZs We can help you say good night to your sleep problems. Here are 10 effective strategies for getting a better night's sleep (and they don't require a trip to the drugstore!) Read more Find a Doctor Looking for a specialist or even a general practitioner? Find a top doc who meets your needs, whether it's a question of insurance, location, or expertise. Get a Best Doctors Recommendation Talk About It More topics Are science and medicine going too far, or not far enough, to cure disabilities and disease? The latest medical headlines sound like science fiction, forecasting breakthroughs such as cloning pigs to produce transplant organs, implanting computer chips in the brain to cure paralysis and using human embryos to cure Alzheimer's, Parkinson's and other diseases. Do you think scientists are going too far in their quest to end aging, disease and pain? Or should research and funding in these areas be increased? Special Sections The Eat More Diet We'll tell you how to eat for longevity cook meals like a professional chef, and make healthy

9. POEMS Syndrome poems syndrome Guide picks. A plasma cell NORD poems syndrome Medicalinformation (technical) on the disorder. Tufts poems syndrome http://rarediseases.about.com/cs/poemssyndrome/

zfp=-1 About Rare/Orphan Diseases Search in this topic on About on the Web in Products Web Hosting Rare/Orphan Diseases with Mary Kugler Your Guide to one of hundreds of sites Home Articles Forums ... Help zmhp('style="color:#fff"') Subjects BUYER'S GUIDE Before You Buy Top Picks Sites for Online Specialty Shopping ... All articles on this topic Stay up-to-date! Subscribe to our newsletter. Advertising Free Credit Report Free Psychics Advertisement POEMS Syndrome Guide picks A plasma cell dyscrasia (bone marrow disorder) that causes multiple body system disorders, including neuropathy, organ overgrowth, glandular problems, and skin changes. Mayo Clinic: Information About POEMS Syndrome Excellent, easy to understand information on the disorder, from the Hematology Division, Department of Internal Medicine, Mayo Clinic Rochester (U.S.). NORD: POEMS Syndrome Medical information (technical) on the disorder. Tufts: POEMS Syndrome Listing of medical journal articles related to POEMS syndrome, from Tufts University Neurology (U.S.). Email this page! Sponsored Links Need Health Insurance?

10. Reversible Pulmonary Hypertension In POEMS Syndrome Another Etiology Of Triggere Reversible pulmonary hypertension in poems syndrome another etiology of triggered pulmonary vasculopathy? http://www.pulsus.com/CARDIOL/16_08/paci_ed.htm

forgot your password? CASE REPORTS August 2000, Volume 16, Number 8: 1007-1010 Reversible pulmonary hypertension in POEMS syndrome – another etiology of triggered pulmonary vasculopathy? G Paciocco, E Bossone, H Erba, M Rubenfire. Key Words: Pulmonary hypertension Order Full Text -For a nominal fee order online and receive a copy of this article either by email, fax or mail Pdf Format - Registered users can view the complete article in Pdf format. REGISTERED USERS LOGIN REGISTER NOW! Order Full Text -For a nominal fee order online and receive a copy of this article either by email, fax or mail Pdf Format - Registered users can view the complete article in Pdf format.

11. Characteristics Of POEMS Syndrome, Mayo Clinic In Rochester, Minn. Disease Characteristics. What are the symptoms of poems syndrome? Who is affectedby poems syndrome? poems syndrome is very rare. Its cause is not known. http://www.mayoclinic.org/poems-rst/characteristics.html

search: Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services POEMS Syndrome POEMS Syndrome Treatment Disease Characteristics Appointments Clinical Trials ... Medical Services Disease Characteristics What are the symptoms of POEMS Syndrome? The term "POEMS" is actually an acronym for the most common symptoms and signs of the syndrome: P O E M S Other common abnormalities included in the syndrome include: Fatigue and weakness Edema (swelling of the ankles and legs) Enlarging breast tissue in both men and women Generalized aches and pains Ascites (fluid collection in the abdomen) Changes in vision Some patients have a coexisting disorder called Castleman's disease, which is an abnormality of the lymph nodes. Though the majority of patients have abnormal bone X-rays, most will not have bone pain. In order to have the syndrome, you do not need to have all the features. All patients, however, have nerve damage and a "plasmaproliferative disorder" and/or Castleman's disease. It is important to identify an incomplete POEMS syndrome because you may be at risk to develop some of the other symptoms later. Who is affected by POEMS syndrome?

12. F000516c - POEMS Syndrome 5/16/00 (Del Rio) Group Tuesday Interns RE A 24 year old African American fe male with undiagnosed fever and renal insufficiency. Question What is the poems syndrome? whether there are peculiarities of the poems syndrome (a multisystemic disorder associated with polyneuropathy, http://www.emory.edu/WHSCL/grady/amreport/litsrch99/f000516c.html

[litsrch99/page_header.html] POEMS Syndrome 5/16/00 (Del Rio) Group: Tuesday Interns RE: A 24 year old African American fe male with undiagnosed fever and renal insufficiency. Question: What is the POEMS syndrome? From Dr. Del Rio: "POEMS is a multisystemic disorder associated with polyneurophathy, organomegaly, endocrinopathies, M-spike, and skin changes." Unique Identifier: 95234515 Authors: Cuellar ML. Garcia C. Molina JF. Institution: Louisiana State University School of Medicine, Department of Medicine, New Orleans 70112, USA. Title: Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. [Review] [66 refs] Source: Current Opinion in Rheumatology. 7(1):58-64, 1995 Jan. Link Directly to Fulltext article in Ovid Unique Identifier: 95077020 Authors: Soubrier MJ. Dubost JJ. Sauvezie BJ. Institution: Rheumatology Service, Hopital G. Montpied, Clermont-Ferrand, France. Title: POEMS syndrome: a study of 25 cases and a review of the literature. French Study Group on POEMS Syndrome.: [Review] [110 refs] Source: American Journal of Medicine. 97(6):543-53, 1994 Dec.

13. POEMS Syndrome Background. poems syndrome stands for Polyneuropathy Organomegaly EndocrinopathyMonoclonal gammopathy Skin lesions SYNONYMS, None. INCIDENCE, Rare. http://www.thedoctorsdoctor.com/diseases/poems.htm

Background POEMS syndrome stands for: Polyneuropathy Organomegaly Endocrinopathy Monoclonal gammopathy Skin lesions SYNONYMS None INCIDENCE Rare AGE-RANGE AND MEDIAN May be in childhood SEX (MALE:FEMALE) Males favored LABORATORY/RADIOLOGIC/OTHER TESTS CHARACTERIZATION Monoclonal protein spike Level is low and usually IgG or IgA HISTOLOGICAL TYPES CHARACTERIZATION Bone marrow Often osteosclerotic myeloma with multiple sclerotic bony lesions admixed with the plasma cells Almost all patients have lamba light chains Skin Glomeruloid hemangiomas Atlas of Tumor Pathology-Tumors of the Bone Marrow. Volume 9, Third Series. AFIP Press. 1994. Commonly Used Terms Hematologic-Lymphatic Disorders Multiple myeloma Last Updated 6/22/2001 Send mail to psdermpath@earthlink.net with questions or comments about this web site.

14. Erythema Elevatum Diutinum Acroosteolysis Celiac disease Crohn's disease HIV-1 Hyperimmunoglobulinemia D IgAparaproteinemia Lymphoma Myelodysplasia poems syndrome Pyoderma gangrenosum http://www.thedoctorsdoctor.com/diseases2/eed.htm

15. Member Sign In poems syndrome, also known as the CrowFukase syndrome, was firstreported in 1956. Focus On http://www.medscape.com/viewarticle/409056

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16. POEMS Syndrome A Case Report And Discussion poems syndrome, also known as the CrowFukase syndrome, was first reported in 1956.Focus On Discussion. poems syndrome is rarely reported in Caucasians. http://www.medscape.com/viewarticle/409056_3

17. Health Library - POEMS Syndrome poems syndrome. Synonyms Disorder Subdivisions General Discussion Resources POEMSsyndrome is an extremely rare multisystem disorder. http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

18. NORD - National Organization For Rare Disorders, Inc. poems syndrome. To purchase fulltext report ($7.50) View Cart/Checkout. Copyright1991, 2000, 2002 Synonyms of poems syndrome Crow-Fukase Syndrome; PEP Syndrome; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=POEMS Syndrom

19. Successful Treatment Of POEMS Syndrome With Autologous Case Report. Successful treatment of poems syndrome with autologous hematopoieticprogenitor cell transplantation. The spectrum of poems syndrome. http://www.nature.com/cgi-taf/DynaPage.taf?file=/bmt/journal/v28/n3/full/1703108

20. Nature Publishing Group Case Report. Peripheral blood stem cell transplantation for poems syndrome. doi10.1038/sj.bmt.1703670.Keywords. poems syndrome; autologous PBSCT; toxicity. http://www.nature.com/cgi-taf/DynaPage.taf?file=/bmt/journal/v30/n6/abs/1703670a

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