41. A P.E.T. Activation Study Of Progressive Aphasia: Developing New Standards For I primary progressive aphasia (PPA) affords the opportunity to define these correlates,since its pathology does not break down the coupling of regional cerebral http://pet.radiology.uiowa.edu/webpage/Research/research projects/Activation.htm

A P.E.T. Activation Study of Progressive Aphasia: Developing New Standards for Imaging Defective Cognition and Understanding Cerebral Disease Thomas Grabowski, MD In order to apply activation studies using positron emission tomography (P.E.T.) to the study of patients with neurological conditions such as stroke or dementia, it is desirable to .measure reliably the physiological correlates of defective task performance in normals and in patients with neuropathologic conditions which neither interfere with local vascular regulation nor cause global cognitive deficits. Primary progressive aphasia (PPA) affords the opportunity to define these correlates, since its pathology does not break down the coupling of regional cerebral blood flow (RCBF) to synaptic activity, nor does it leadto-impairments in attention, motivation and reasoning. Therefore, activation maps obtained using the [ O]water for language tasks in PPA will help to interpret activation studies of other diseases affecting cognition. We propose to employ modified versions of two language tasks which we have investigated in young normal subjects: verb generation and picture naming. Progressive aphasics will be studied longitudinally, with three MRI and three P.E.T. scans at one-year intervals. Elderly normal controls will be studied in a single session using the same tasks and also under experimental conditions designed to induce errors in task performance. Image analysis will be performed in the Human Neuroanatomy and Neuroimaging Laboratory using local software (PET-BRAINVOX) which supports both anatomically- based and standard pixel-based analyses.

42. Curso De Neurología De La Conducta Y Demencias primary progressive aphasia with focal neuronal achromasia . Neurology, 41882886. The pathology and nosology of primary progressive aphasia . http://oaid.uab.es/nnc/html/entidades/web/22cap/c22_11.html

[1] PICK, A. (1892). "Über die Beziehungen der senilen Hirnatrophie zur Aphasie". Prag. Med. Wchnschr. [2] ONARI, K.; SPATZ, H. (1926). "Anatomische Beitrage zur Lehre von der Pickschen umschreibenen Grosshirnrinden-Atrophie ("Picksche Krankheit")". [3] CONSTANTINIDIS, J.; RICHARD, J.; TISSOT, R. (1974). "Pick’s disease - histological and clinical correlations". European Neurology, [4] BRUN, A. (1987). "Frontal lobe degeneration of non-Alzheimer type. I. Neuropathology". Arch. Gerontol. Geriatr., [5] GUSTAFSON, L. (1987). "Frontal lobe generation of non-Alzheimer type. II. Clinical picture and differential diagnosis". Arch. Gerontol. Geriatr. [6] NEARY, D.; SNOWDEN, J. S.; NORTEEN, B.; GOULDING, P. (1988). "Dementia of frontal lobe type". Journal of Neurology, Neurosurgery, and Psychiatry

43. Aphasia With A Person Who Has Aphasia SOME DOs and DON'Ts Impact of Aphasia on Patientsand Families Understanding primary progressive aphasia Technology Resource http://www.communicationdisorders.net/Aphasia.html

Aphasia Information Books Online Articles Organizations ... HOME Information Language and Communication in Aphasia. From the Glasgow University Psychology Department Adult Aphasia : ASHA Aphasia Fact Sheet From the National Aphasia Association Adult Aphasia How To Communicate With A Person Who Has Aphasia : SOME DOs and DON'Ts Impact of Aphasia on Patients and Families Understanding Primary progressive Aphasia Technology Resource Information Sheet Books SELECTED RESOURCES Lists books, pamphlets videos, and other resources useful to people with aphasia, their families and professionals who work with them. POSTERS, ID CARDS, BOOKMARK, BROCHURE printed materials that promote aphasia awareness, available for purchase from NAA Online Articles Aphasia Take the Aphasia Quiz When Brain Damage Disrupts Speech The Words I lost ... Keep on Trying Organizations National Aphasia Association Aphasia Hope Foundation Peninsula Stroke Association SpeechTherapist.net ... WebMD, Inc State Organizations Aphasia Center of California Research Functional Restoration-Chiropractic Neurology NAA Research Support List Serves listserv@listserv. arizona.edu

44. Untitled Primaire Progressieve Afasie (primary progressive aphasia, PPA) is een zeldzaamneurologisch syndroom, waarbij iemands taalvermogen langzaam steeds meer http://www.afasie.nl/nieuws/primaire.progressief.html

Primaire Progressieve Afasie Wat is afasie? Zoals al onze lezers weten, is afasie een taalstoornis, waarbij mensen van het ene op het andere moment moeite hebben met spreken, begrijpen, lezen en/of schrijven. Afasie is altijd het gevolg van hersenletsel, meestal een CVA (Cerebro Vasculair Accident, een beroerte) of een trauma. De gevolgen van afasie verschillen van persoon tot persoon - vaak wordt nog wel enige verbetering bereikt door logopedische behandeling. Wat is Primaire Progressieve Afasie (PPA)? Bestaat er hulp voor mensen met PPA? Waar vind ik meer informatie over PPA? Mensen die het Engels goed beheersen en toegang hebben tot het Internet, kunnen een kijkje nemen op de site van de National Aphasia Association ( www.aphasia.org ) U kunt zich ook abonneren op de PPA-newsletter (ook in het Engels): wie beschikt over een Internetaansluiting gaat naar www.brain.nwu.edu/core/ppa.htm ; anderen kunnen contact opnemen met het Northwestern Alzheimers' Disease Center PPA News, 320 E. Superior, Searle 11-504, Chicago, IL 60611, USA. In een medische bibliotheek of via Internet zijn de volgende artikelen te vinden: 1. Mesulam M-M. Slowly progressive aphasia without dementia. Annals of Neurology, 11:592-598, 1982

45. Aphasia Center Of California My family member was recently diagnosed with primary progressive aphasia. PrimaryProgressive Aphasia (PPA) differs from aphasia following stroke. http://www.employees.org/~accadmin/answers.html

How do I attend Aphasia Center of California programs? The first step in being admitted into our programs is to call the Aphasia Center of California at (510) 336-0112. During this phone call, we will gather information including relevant medical history and the current severity and type of aphasia. We will also determine which of our treatments or classes are of most interest to the person with aphasia. An appointment will then be made for an initial visit to our program. I have a family member with aphasia who lives outside of the Northern California area. Can we come to the Aphasia Center of California for a few months of treatment? The Aphasia Center of California's community based programs are designed to provide long term treatment and support for all those affected by aphasia. We recommend that individuals who attend our programs live nearby for at least a 4 month time period so that they can experience the benefit of group communication treatment. How long can I continue to make progress following my stroke?

46. Aphasia Center Of California My family member was recently diagnosed with primary progressive aphasia. Do youhave information on that disorder? How does one know if they have aphasia? http://www.employees.org/~accadmin/faq.html

How do I attend Aphasia Center of California programs? I have a family member with aphasia who lives outside of the Northern California area. Can we come to the Aphasia Center of California for a few months of treatment? How long can I continue to make progress following my stroke? Is there an Aphasia Center with the same programs in my community? ... How does one know if they have aphasia? How do I find a speech-language pathologist in my community who is experienced in working with individuals with aphasia? CLICK HERE FOR Home Who We Are Programs You Can Help ... Contact Us

47. References Understanding primary progressive aphasia. (Date accessed, February 14, 2001). Woburn,MA. What is primary progressive aphasia? (Date accessed March 23,2001). http://webpages.marshall.edu/~yarber1/references.htm

References Cress, King. (1996, Dec.) AAC Strategies for people with PPA without dementia: Two case studies. Augmentative and Alternative Communication Journal. pp. 248-258. Elman, Roberta. (1999). Group Treatment of Neurogenic Communication Disorders. Butterworth-Heinemann, Woburn, MA. Journal of Speech and Hearing Research. pp.27-37 (From[Academic Search Elite]: EBSCO Publishing.) Retrieved April 1, 2001 from the World Wide Web: http://www.epnet.com/ehost/login.html. Understanding Primary Progressive Aphasia. (Date accessed, February 14, 2001). National Aphasia Association [Online]. Available http://www.aphasia.org/NAAppa.html. Wallace, Glorijean. (1999). Adult Aphasia Rehabilitation. Butterworth-Heinemann. Woburn, MA. What is Primary Progressive Aphasia? (Date accessed March 23,2001). Primary Progressive Aphasia Newsletter [Online]. Available http://dementia.ion.ucl.ac.uk/candid/factsheets/facts5.htm Title Page Research Paper

48. Paper primary progressive aphasia and the Role of the SpeechLanguage Pathologist.In deciding on a topic for my research paper I wanted http://webpages.marshall.edu/~yarber1/paper.htm

Primary Progressive Aphasia and the Role of the Speech-Language Pathologist In deciding on a topic for my research paper I wanted to pick something that I was personally interested in. I have a class where we discuss neurogenic disorders such as aphasia. This is a class I enjoy alot and I am very intrigued with the things we have learned about aphasia. As a focus for my research I chose to investigate a particular type of aphasia that I knew little about. While I have some knowledge about the disorder of aphasia, I have little understanding about a type of aphasia, called primary progressive aphasia (PPA). My specific interests were to learn how the disorders of aphasia and PPA differ, how they are alike, and what role the speech language pathologist might play when treating patients with PPA. Just as the amount of time for each stage may vary so can the effects of PPA on language. The patient may have naming difficulties, for example the patient may not be able to name something they use everyday like a toothbrush. They may substitute the wrong word, for example they may ask for a cup when they want a plate ("What is PPA?", 1996). Since the initial symptoms of PPA are similar to those of aphasia the patient could benefit from some of the same types of speech therapy (Cress,1999). I then decided to look at what role the SLP played in the rehabilitation of PPA. It was very hard to find any information specifically on therapy for PPA so I looked at what the role of the SLP is in the therapy of persion with aphasia in general. The rehabilitation of the person with aphasia involves several professions but the entire team looks to the SLP to learn the best ways of communication with the patient. They also provide the best means of communicating so the patient can express his/her basic needs. The SLP also helps the family of the patient deal with the disorder. The SLP will assist them in learning about the disorder and ways to communicated with the patient (Wallace, 1999).

49. Selected Publications Of The Clinical Neuropsychology Faculty: Mesulam MM, Johnson N, Grujic Z, Weintraub S Apolipoprotein E Genotypesin primary progressive aphasia, Neurology, 49, 5155, 1997. http://www.clinpsych.northwestern.edu/htm/johnsonpub.htm

Selected publications of the clinical neuropsychology faculty Nancy Johnson, PhD Papers Johnson N , Petersik J: Preliminary findings suggesting cyclic changes in visual contrast sensitivity during menstrual cycle. Perceptual Motor Skills, 64, 587, 1987. Mesulam MM, Johnson N , Grujic Z, Weintraub S: Apolipoprotein E Genotypes in Primary Progressive Aphasia, Neurology, 49, 51-55, 1997. Grujic Z, Mapstone M, Gitelman D, Johnson N , Weintraub S, Hays A. Kwasnica C, Harvey R, Mesulam MM: Dopamine agonists reorient visual exploration away from the neglected hemispace. Neurology, 51, 1395-1397, 1998. Weintraub S, Peavy GM, O'Connor M, Johnson N , Acar D, Guinessey J, Janssen I. Three Words-Three Shapes: A Clinical Test of Memory. Journal of Clinical and Experimental Neuropsychology, 22(2): 267-278, 2000. Abstracts Johnson N , Helmstetter F: Exposure to white noise results in decreased sensitivity to thermal stimuli in humans. Society for Neuroscience, 19: 965, 1993. Johnson N , Helmstetter F: Conditional fear-induced hypoalgesia in humans using a non-noxious UCS. Socirty for Neuroscience, 20: 360, 1994. Del Toro D, Goldbaum A

50. Selected Publications Of The Clinical Neuropsychology Faculty: primary progressive aphasia Longitudinal course, neuropsychologicalprofile and language features. Arch Neurol 1990; 47 13291335. http://www.clinpsych.northwestern.edu/htm/weinpub.htm

Selected publications of the clinical neuropsychology faculty Sandra Weintraub, PhD, ABPP Kaplan E, Goodglass H, Weintraub S The Boston Naming Test . Philadelphia, PA: Lea and Febiger; 1983. Weintraub S , Mesulam M-M. Visual hemispatial inattention: Stimulus parameters and exploratory strategies. J Neurol Neurosurg Psychiatry 1988; 51:1481-1488. Spiers PA, Schomer D, Blume HW, Kleefield J, O'Reilly GO, Weintraub S , Osborne-Shafer P, Mesulam M-M. Visual neglect during intracarotid amytal testing. Neurology 1990; 40:1600-1606. Daffner KR, Ahern GHL, Weintraub S , Mesulam M-M. Dissocciated neglect behavior following sequential strokes in the right hemisphere. Ann Neurol 1990; 28:97-101. Weintraub S , Rubin NP, Mesulam M-M. Primary progressive aphasia: Longitudinal course, neuropsychological profile and language features. Arch Neurol 1990; 47: 1329-1335. Daffner KR, Scinto LFM, Weintraub S , Guinessey J, Mesulam M-M. Diminsished curiousity in patients with probable Alzheimer's disease as measured by exploratory eye movements. Neurology 1992; 42:320-328. Kapust LR

51. SpringerLink: Neuroradiology - Abstract Volume 39 Issue 8 (1997) Pp 556-559 Imaging in primary progressive aphasia. Abstract primary progressive aphasia (PPA)presents with aphasia, with or without other minor cognitive dysfunction. http://link.springer-ny.com/link/service/journals/00234/bibs/7039008/70390556.ht

Neuroradiology ISSN: 0028-3940 (printed version) ISSN: 1432-1920 (electronic version) Table of Contents Abstract Volume 39 Issue 8 (1997) pp 556-559 Imaging in primary progressive aphasia K. Abe (1), H. Ukita (2), T. Yanagihara (1) (1) Department of Neurology, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565, Japan (2) Rehabilitation Service, Osaka University Hospital, Osaka, Japan Received: 19 August 1996 Accepted: 9 September 1996 Abstract Primary progressive aphasia (PPA) presents with aphasia, with or without other minor cognitive dysfunction. We report five patients with PPA to show the correlation between their clinical signs and imaging findings. The patients can be divided into those with nonfluent (group 1) and those with fluent (group 2) aphasia. The characteristic speech impairment was bradylalia in group 1 and word amnesia in group 2. Impairment of comprehension was common but mild in both groups. On MRI, patients in group 1 showed predominantly left frontal and perisylvian atrophy with reduced uptake in the same region on single photon emission computed tomography (SPECT) using technetium-99m hexamethyl propyleneamine oxime ( Tc HMPAO). Patients in group 2 showed left temporal atrophy involving the superior, middle and inferior temporal gyri, hippocampus and parahippocampal gyrus on MRI and reduced uptake in the same region on SPECT. These findings correlated well with the functional anatomy of speech impairment.

52. SpringerLink: Acta Neuropathologica - Abstract Volume 92 Issue 5 (1996) Pp 534-5 Corticobasal degeneration with primary progressive aphasia and accentuatedcortical lesion in superior temporal gyrus case report and review. http://link.springer-ny.com/link/service/journals/00401/bibs/6092005/60920534.ht

Acta Neuropathologica ISSN: 0001-6322 (printed version) ISSN: 1432-0533 (electronic version) Table of Contents Abstract Volume 92 Issue 5 (1996) pp 534-539 Corticobasal degeneration with primary progressive aphasia and accentuated cortical lesion in superior temporal gyrus: case report and review K. Ikeda (1)(2), Haruhiko Akiyama (1), Shuji Iritani (1)(2), Kase. Koichi (1)(2), Tetsuaki Arai (1)(2), Kazuhiro Niizato (1)(2), Noriomi Kuroki (1)(2), Kenji Kosaka (1)(3) (1) Department of Neuropathology, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156, Japan Tel.: +81-3-3304-5701 (Ext. 345); Fax: +81-3-3329-8035 (2) Tokyo Metropolitan Matsuzawa Hospital, 2-1-1 Kamikitazawa, Setagayaku, Tokyo 156, Japan (3) Department of Psychiatriy, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236, Japan Received: 5 February 1996 / Revised, accepted: 13 May 1996 Abstract Key words Article in PDF-Format Online publication: September 28, 1997 helpdesk.link@springer.de

53. EMedicine - Pick Disease : Article Excerpt By: Anna M Barrett, MD primary progressive aphasia (Weintraub, 1990) is a focal atrophy syndrome thatmay be associated with Pick, Alzheimer, or other pathology; clinically the http://www.emedicine.com/neuro/byname/pick-disease.htm

(advertisement) Excerpt from Pick Disease Synonyms, Key Words, and Related Terms: dementia lacking distinctive histopathology, frontal lobe degeneration, frontal lobe dementia, frontotemporal dementia, frontotemporal dementia linked to chromosome 17, primary progressive aphasia, progressive subcortical gliosis Please click here to view the full topic text: Pick Disease Background: Pick disease (named after Arnold Pick) is a progressive dementia defined by clinical and pathologic criteria. Unlike Alzheimer disease and other dementias that present with cognitive deficits localized to the posterior (parietal) cortex, Pick disease typically affects the frontal and/or temporal lobes. First described in 1892, with the defining pathologic characteristics first reported by Alois Alzheimer in 1911, Pick disease now is considered by some to be part of a "complex" of neurodegenerative disorders with similar or related histopathologic and clinical features (Kertesz, 1994; Kertesz, 1997). Nomenclature history Frontotemporal dementia (of which Pick disease is an example) is a broader term including Pick disease. Frontal lobe dementia is a term signifying neuropsychological features localizing to the frontal lobes. Clinically, Pick disease may be identical or very similar to "frontal lobe degeneration" (Miller, 1997).

54. Surface Dyslexia In Nonfluent Progressive Aphasia This article presents the case of a 59year-old male, JH, with a 6-year historyof primary progressive aphasia (PPA), a disorder characterized by isolated http://www.lab-io.it/abstract/abs53.htm

L a b i o Neuropsicologia on Web Surface Dyslexia in Nonfluent Progressive Aphasia Susan Watt, Regina Jokel, Marlene Behrmann Informazioni sono richiedibili a info@lab-io.it Per informazioni sugli accessi fare click qui

55. [DYSPHAGIA] Primary Progressive Aphasia DYSPHAGIA primary progressive aphasia. A recent article by Westbury,and Bub (1997) primary progressive aphasia A review of 112 cases. http://www.b9.com/dysphagia/1999-June/msg00129.html

56. [DYSPHAGIA] Primary Progressive Aphasia DYSPHAGIA primary progressive aphasia. Please pardon the languagequestion but I am seeking info on primary progressive aphasia. http://www.b9.com/dysphagia/1999-June/msg00086.html

57. Directory :: Look.com primary progressive aphasia (3) Sites. primary progressive aphasiaA description of what this is, the symptoms and its course. http://www.look.com/searchroute/directorysearch.asp?p=594550

58. [Cadig] Reading Notes For December Article 2000). Proactive management o= f primary progressive aphasia. In Builders.McNeil, MR, Duffy, JR (in press). primary progressive aphasia. In http://www.maccs.mq.edu.au/pipermail/cadig/2001-December/000011.html

[Cadig] Reading Notes for December article Karen Croot karen@maccs.mq.edu.au Thu, 20 Dec 2001 18:51:39 +1100 Messages sorted by: [ date ] [ thread ] [ subject ] [ author ] This message is in MIME format. Since your mail reader does not understand karen@maccs.mq.edu.au Messages sorted by: [ date ] [ thread ] [ subject ] [ author ]

59. Michel Habib research on the specific theme of cerebral plasticity in the elderly subject sufferingfrom degenerative pathology, specifically primary progressive aphasia. http://www.criugm.qc.ca/Anglais/habmA.html

Michel.Habib@UMontreal.CA Keywords defining the teaching and/or research interests: Main research themes relations between the brain and mental functions : a variety of clinical research studies in neuropsychology and behavioural neurology. language impairment resulting from brain damage or developmental impairment. Neurobiology of developmental dyslexia. hemispheric lateralization and interhemispheric relations Description of research programming As a guest professor in the Research Centre of the Institut, I would like to focus my research on the specific theme of cerebral plasticity in the elderly subject suffering from degenerative pathology, specifically primary progressive aphasia. My project is entitled: "Cerebral plasticity and functional recovery in cortical degeneration: a model of phonological training in primary progressive aphasia." The goal of this research is to evaluate the effectiveness of intensive training of phonological processes in this disorder and to explore the neurobiological bases for this effectiveness using functional imagery. The challenge in this field of research is clearly fundamental, since the goal is to gain a better understanding of the potential for recovery of a brain that is affected by a neurodegenerative disorder. Moreover, we cannot ignore the medical and economic stakes involved in this research, given the persistent questions surrounding the effectiveness, and hence the justification, for the cognitive management of dementias.

60. Colin David Field primary progressive aphasia Serial neurolinguistic, neuropsychological and radiologicalfindings with neuropathological results. Aphasiology, 9, 495-516. http://www.psychology.adelaide.edu.au/members/external/colinfield/colinfield.htm

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