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         Retinoblastoma:     more books (46)
  1. [Miscellaneous publications not separately catalogued] by Retinoblastoma Society, 1995
  2. Pediatric Ophthalmology and Strabismus
  3. Pediatric Retina
  4. Eye Cancer: An entry from Gale's <i>Gale Encyclopedia of Medicine, 3rd ed.</i> by Thomas Eagan, Ronald, PhD Watson, et all 2006
  5. Benzo[a]pyrene up-regulates the expression of the proliferating cell nuclear antigen (PCNA) and multixenobiotic resistance polyglycoprotein (P-gp) in Baltic ... Biochemistry and Physiology, Part C] by A. Prevodnik, K. Lilja, et all 2007-03-01
  6. Retinal cryopexy: An entry from Gale's <i>Gale Encyclopedia of Surgery</i> by Monique, PhD Laberge, 2004
  7. Transcriptional Control of Cell Growth: The E2F Gene Family (Current Topics in Microbiology and Immunology)
  8. Gale Encyclopedia of Medicine: Eye cancer by Ronald Scott Watson PhD, 2002-01-01
  9. Ophthalmic Oncology (M.D. Anderson Solid Tumor Oncology Series)
  10. Ocular Oncology
  11. Intraocular Tumors: An Atlas and Text by Jerry A. Shields, Carol L. Shields, 2007-12-03
  12. Atlas of Intraocular Tumors by Jerry A. Shields, Carol L. Shields, 1999-04-12
  13. Tumors of the Eye
  14. Rb and Tumorigenesis (Medical Intelligence Unit)

41. Society For Neuroscience Login Directory Merchandise Contact Us
Full size image available below, The retinoblastoma Gene In the late 1980s, scientistsisolated the gene, called Rb, that is mutated in retinoblastoma.
http://apu.sfn.org/content/Publications/BrainBriefings/retinoblastoma.html
The Journal of Neuroscience Neuroscience Quarterly Brain Briefings Brain Backgrounders ... Publications Catalog
Full size image available below The Retinoblastoma Gene Studies of a rare childhood tumor, retinoblastoma, reveal an important class of genes called tumor suppressers that control cell division. The retinoblastoma tumor suppresser gene produces a protein important for nervous system development, aging and replication of some viruses. Studies of this gene and other tumor suppressers are leading to new ideas for preventing or treating retinoblastoma and other diseases. Think of riding a rollercoaster without brakes. The thrilling speed and curves quickly become frightening as the coaster accelerates out of control.
Like a rollercoaster, the cells in our bodies normally operate with great precision, safely cycling between rapid cell division and rest. Occasionally, however, a cell's molecular "brakes" fail, allowing run-away cell growth and division.
Many of the first insights into the importance of cellular "braking" come from studies of an eye tumor called retinoblastoma that affects about 400 children a year.

42. Retinoblastoma
retinoblastoma, Book, Home Page. Page, Hematology and Oncology Index.Epidemiology Rare malignant tumor
http://www.fpnotebook.com/EYE44.htm
Home About Links Index ... Editor's Choice Paid Advertisement (click above). Please see the privacy statement Ophthalmology Hematology and Oncology Pediatrics Retinoblastoma Retinoblastoma Book Home Page Cardiovascular Medicine Dental Dermatology Emergency Medicine Endocrinology Gastroenterology General Medicine Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Ophthalmology Index Anterior Conjunctival Disorders Corneal Disorders Cardiovascular Medicine Examination Glaucoma Hematology and Oncology Injury Lacrimal Lens Lid General Neurology Pediatrics Pharmacology Prevention Pupil Retina Rheumatology Sclera Surgery Symptom Evaluation Vision Page Hematology and Oncology Index Peds Retinoblastoma
  • Epidemiology Rare malignant tumor of retina Incidence : 1 in 20,000 live births Average age of diagnosis: 12-18 months old Possible hereditary etiology Pathophysiology Retinal germ cell tumor Tumor invades vitreous or grows beneath retina Signs: Screen at every well child check in first 2 years Pupillary Light Reflex by direct ophthalmoscope White ( Leukokoria ) replaces Red Reflex (60% of cases) Strabismus testing Management Enucleation (may not be required in early treatment) Radiation Laser photocoagulation Cryotherapy Systemic Chemotherapy Associated conditions Strabismus Osteogenic Sarcoma Prognosis Uniformly fatal without treatment
  • 43. Retinoblastoma
    Image that's a link to Genetics Education Center Support Page retinoblastoma.National http//www.acor.org retinoblastoma resources. A
    http://www.kumc.edu/gec/support/retinobl.html
    Retinoblastoma
    National Retinoblastoma Research and Support Foundation (NRRSF)
    900 N.W. 17th Street, Room 257 PO Box 016880 Miami, FL 33101-6880 Phone: (800) 226-2734
    National Retinoblastoma Parents Group
    603 Fourth Range Rd Pembroke, NH 03275 Phone: (603) 224-4085
    Institute for Families of Blind Children
    P.O.Box 54700, Mailstop 111 Los Angeles, Ca. 90054-0700 Phone: (213) 669-4649 Contact: Nancy Chernus-Mansfield
    National Cancer Institute
    Office of Cancer Communications Center Drive, MSC 2580 Bethesda, MD 20892-2580 Cancer Information Service: 1-800-4-CANCER (1-800-422-6237) or TTY: 1-800-332-8615
    R-BLASTOMA electronic mailing list for retinoblastoma patients and their parents. To subscribe, email: LISTSERV@listserv.acor.org In the body of message, write only: SUBscribe R-BLASTOMA Yourfirstname Yourlastname
    A web interface to subscribe also exists at: or contact G Frydman gfrydman@acor.org , Association of Cancer Online Resources, Inc. http://www.acor.org
    Retinoblastoma resources A Parent's Guide to Understanding Retinoblastoma
    • What is Retinoblastoma? Genetics of Retinoblastoma Genetic Testing Diagnosis of Retinoblastoma Signs and Symptoms of Retinoblastoma Classification of Retinoblastoma Treatment of Retinoblastoma Long Term Consequences of Retinoblastoma
    Retinoblastoma Foundation
    Also See:

    44. Retinoblastoma Factsheet
    RNIB homepage, Search RNIB site for retinoblastoma factsheet. What is retinoblastoma?retinoblastoma How is retinoblastoma Identified. Children
    http://www.rnib.org.uk/info/retino.htm
    Search RNIB site for:
    Retinoblastoma factsheet
    What is Retinoblastoma?
    Retinoblastoma is a malignant tumour or cancer which develops in the cells of the retina, the light sensitive lining of the eye. It can affect either one eye only, unilateral Retinoblastoma, both eyes, bilateral Retinoblastoma or occasionally include intracranial involvement which is described as trilateral Retinoblastoma. Approximately two thirds of children with Retinoblastoma have one eye affected and one third of children with Retinoblastoma have tumours in both eyes. Retinoblastoma has one of the best cure rates of all childhood cancers and over 9 out of 10 children with Retinoblastoma can be cured (Kingston, 1997).
    How many children get this ocular cancer?
    Retinoblastoma is the most common primary ocular malignancy in childhood with a frequency of about 1:20,000. Retinoblastoma may occur sporadically or it may be inherited. 40% of incidences of Retinoblastoma are familial and 60% occur sporadically.
    How is Retinoblastoma Identified
    Children with bilateral Retinoblastoma tend to present during the first year of life whilst the peak age of diagnosis with unilateral Retinoblastoma is between 24 and 30 months.

    45. Understanding Retinoblastoma
    Search RNIB site for Understanding retinoblastoma. retinoblastoma is a malignanttumour arising in the light sensitive lining of the eye known as the retina.
    http://www.rnib.org.uk/info/retinob.htm
    Search RNIB site for:
    Understanding retinoblastoma
    In the UK there are about 45 new cases each year, equivalent to approximately one case in every 20,000 live births. There is no significant variation between the sexes. In approximately two-thirds of children, only one eye is affected (unilateral) but in the remaining third, tumours develop in both eyes (bilateral). It is a tumour of early childhood and less than 5% of cases are diagnosed after the age of five years. The peak age of diagnosis for children with unilateral disease is between 24 and 29 months whilst children with bilateral disease tend to present earlier, usually during the first year of life.
    Genetics
    Retinoblastoma occurs in two forms: a genetic, hereditary variant and a non-genetic, non-hereditary form. Approximately 40% of children with retinoblastoma have the genetic form. This includes all children with bilateral disease and about 5% of those with unilateral. In 10% of patients there is a known family history while the rest develop the disease as a result of a new germ-line mutation. Patients with the genetic form have an increased susceptibility to the subsequent development of other malignant tumours. Although the cause of retinoblastoma is unknown, we do know that its development is controlled by a 'suppressor' or regulating gene known as the human retinoblastoma susceptibility gene. This gene is recessive at the cellular level since inactivation or loss of both alleles of the gene appears to be necessary for the development of the disease. The gene is located on the long arm of chromosome 13 and has been implicated in the development of other cancers including osteosarcoma, small cell carcinoma of the lung, bladder, breast and various soft tissue sarcomas.

    46. Retinoblastoma Innovations And Patents
    retinoblastoma Innovations and Patents © 2002, XQ23.COM ResearchHealth Index Bibliograhphic Active compounds Banding analysis
    http://www.xq23.com/chromosome_3/retinoblastoma.html
    retinoblastoma Innovations and Patents © 2002, XQ23.COM Research
    Health Index

    Bibliograhphic:

    Active compounds

    Banding analysis

    Biochemical Indicators

    Biological Dosimetry
    ...
    nematodes

    Recent U.S. patents related to retinoblastoma:
    6,384,202: Cell-specific active compounds regulated by the cell cycle
    6,384,022: Prodrugs of NAALAdase inhibitors 6,383,814: Cationic amphiphiles for intracellular delivery of therapeutic molecules 6,383,796: Nucleic acids encoding HSKIF21B, a kinesin motor protein 6,383,785: Self-enhancing, pharmacologically controllable expression systems 6,383,494: Methods and composition for eliciting an immune response with gp96-peptide complexes 6,383,493: Methods and compositions for eliciting an immune response with hsp70-peptide complexes 6,383,492: Treatment of infectious diseases with gp96-peptide complexes 6,383,491: Prevention of infectious diseases with hsp90-peptide complexes 6,383,486: Inhibitors of vascular endothelial growth factor activity, their uses and processes for their production 6,380,373: Steroid receptor coactivator compositions and methods of use

    47. St. Jude Children's Research Hospital
    retinoblastoma. The tumor may involve one or both eyes. Incidence Anestimated 250 to 300 children a year will develop retinoblastoma.
    http://www.stjude.org/medical/retinoblast.htm
    About Us Search Career Opportunities News Donate Now Contact Us Research ... Phase I Studies
    Home
    St. Jude's "bench to bedside" approach to finding cures for the catastrophic diseases of childhood allows St. Jude patients more efficient access to the latest research findings available. Our protocols are freely shared with physicians and healthcare institutions throughout the world. W e are actively recruiting for specific clinical studies. Patients must be referred by their physician Click here to refer a patient to St. Jude or for referral, consultation and treatment policies. Parents who want to know if their child is eligible to be treated at St. Jude should have the child’s physician call the toll free number below. Note: There may not be treatment protocols in place for all of the conditions in the lists to the left, or for all stages or treatment phases of every disease listed. For information about whether a specific disease is currently being treated in a clinical trial at St. Jude, about malignancies not listed, or about other catastrophic diseases in the categories listed here or t o determine if a child is eligible for treatment at St Jude

    48. EMedicine - Retinoblastoma : Article By Marichelle L Aventura, MD
    retinoblastoma retinoblastoma is the most common primary ocular malignancy ofchildhood.The first description of a tumor resembling retinoblastoma was by
    http://www.emedicine.com/oph/topic346.htm
    (advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Ophthalmology Retina
    Retinoblastoma
    Last Updated: February 18, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: intraocular childhood malignancy, tumor, ocular malignancy, RB gene, retinoblastoma gene AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography
    Author: Marichelle L Aventura, MD , Consulting Staff, Department of Ophthalmology, Santo Tomas University Hospital of Manila Coauthor(s): Manolette R Roque, MD , Chief of Service, Immunology and Uveitis Service, Consulting Staff, Cornea and Refractive Surgery Service, QC Eye Center, Cavite Eye and ENT Center, Makati Eye Laser Center Thomas M Aaberg, Jr, MD , Ophthalmology, Associated Retinal Consultants Marichelle L Aventura, MD, is a member of the following medical societies: American Academy of Ophthalmology Editor(s): Gerhard W Cibis, MD

    49. Retinoblastoma - DrGreene.com - Caring For The Next Generation
    Dr. Greene talks about retinoblastoma, which is cancer of the eye,usually found in infants and toddlers. retinoblastoma. A patient
    http://www.drgreene.com/21_813.html
    QUICK SEARCH A - Z Guide Allergies Allergy Care Guide Asthma Care Guide Bedwetting Breastfeeding Childhood Obesity Diabetes Care Guide Ear Infections Genetics Immunizations Infectious Diseases Parenting Potty Training Rashes Safety Sleep DrGreene.com Topic Centers Mission Reviews Awards Readers Comments Press Room Partners and Supporters Contact Us Pediatric Information A-Z Guide Allergy Care Guide Asthma Care Guide Diabetes Care Guide DrGreene´s Chats FAQ Fast Facts Feature Articles Guidelines Pediatric Updates Special Feature Top Tips Community Activty Guide Advanced Search Community Central Chat Chat Schedule Cute Faces Family Friendly Recipes Parent-to-Parent Resources The DrGreene Team Newsletter Prenatal Newborn Infants Toddlers Pre-Schoolers School Age Teens / Adolescents Multimedia Library Children's Health Fertility
    Retinoblastoma
    A patient of mine was recently diagnosed with retinoblastoma. Can you tell me about the disease and is it hereditary? Thanks.
    Registered Nurse
    Carlsbad, New Mexico

    When you see the red-eye effect in a photograph, you are looking at a clue to the presence or absence of retinoblastoma, an important childhood cancer. Retinoblastoma, which is usually found in

    50. RETINOBLASTOMA
    retinoblastoma. What is retinoblastoma? retinoblastoma is the commonest eye cancerin infancy and childhood, affecting one in seventeen thousand live births.
    http://www.nevdgp.org.au/geninf/std_misc/RETINOBLASTOMA.htm
    RETINOBLASTOMA What is Retinoblastoma?
    Retinoblastoma is the commonest eye cancer in infancy and childhood, affecting one in seventeen thousand live births. The retina is the living photographic film in the back of the eye. Retinoblastoma means tumours in the retina.
    It occurs in infants and children up to five years old and, if diagnosed early, 95% of children with retinoblastoma survive. Retinoblastoma can appear in one or both eyes. What causes Retinoblastoma?
    The cause is unknown. What is known is that the child's genetic material (DNA) plays a major part. If both eyes are affected there is a 50% chance that the disease will be passed on to the child's offspring. In these cases genetic counselling is important. If only one eye is affected there is no significant risk of the disease being passed on to the next generation unless others in the family are affected. What should I look for?
    Retinoblastoma can show up in several ways. As the young infant can't communicate, the parents need to watch for anything unusual about the child's eyes.
    Flashlight photos may reveal a "cat's eye reflex". A normal retina reflects a red colour in a photo taken using a flash (cameras without red-eye reduction). If the child has the tumours they will reflect a white light instead. Look at flash photos carefully to see if the red reflex in each eye is the same. A squint (the child's eyes do not line up properly) or poor sight can be the first sign of retinoblastoma. This may happen if the tumours grow across the reading centre of the eye.

    51. Retinoblastoma
    retinoblastoma is the commonest eye tumor in childhood. retinoblastoma Whatis retinoblastoma? retinoblastoma is a cancer of the eye in children.
    http://health.indiamart.com/eye-care/retinoblastoma.html

    You Can Advertise Here
    HealthCare Eye Care
    Retinoblastoma
    What is retinoblastoma?
    Retinoblastoma is a cancer of the eye in children. It originates from the retina , the light sensitive layer, in eye. It is the commonest eye tumor of the eye in childhood. . This tumor may involve one (75% of cases) or both (25% of cases) eyes in a child. Untreated, retinoblastoma is almost always fatal, hence the importance of early diagnosis and treatment
    Is it hereditary?
    Yes in some cases it may be hereditary. Majority of cases (90%) has no family history of such disease; while a small percentage (10%) of newly diagnosed cases have other family members with retinoblastoma.
    Of all the cases of retinoblastoma, in 60% of cases it does not get transmitted to the next generation, while in 40% of cases it may get transmitted in the next generation. Therefore it is important to have a genetic counseling before having a baby to determine the risk of another child getting the same disease. Also, the siblings and children of the patients with retinoblastoma should be examined periodically in their childhood to detect any possible tumor early.
    What are the symptoms of retinoblastoma?

    52. Retinoblastoma: BC Cancer Agency
    Eye or Orbital retinoblastoma Print Wizard Print this Page Cancerof the eyeball arising from the retina; Most common eye malignancy
    http://www.bccancer.bc.ca/PPI/TypesofCancer/EyeorOrbital/Retinoblastoma/
    Agency Links: Home Contact Us Legal Privacy ... Eye or Orbital Retinoblastoma Eye or Orbital Retinoblastoma Diagnosis Etiology Prevention Symptoms ... Vascular Tumours Eye or Orbital - Retinoblastoma
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    • The genetic basis of this disorder is becoming much better understood

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    Unofficial document if printed . Please refer to the following web address for up-to-date information:

    53. Retinoblastoma: BC Cancer Agency
    For information see retinoblastoma under the Eye and Orbital section of Typesof Cancer. Neuroblastoma. retinoblastoma. Rhabdomyosarcoma. Wilm's Tumour.
    http://www.bccancer.bc.ca/PPI/TypesofCancer/ChildhoodCancer/Retinoblastoma.htm
    Agency Links: Home Contact Us Legal Privacy ... Childhood Cancer Retinoblastoma Types of Cancer Childhood Cancer Bone Cancer Brain Tumours ... Neuroblastoma Retinoblastoma Rhabdomyosarcoma Wilm's Tumour Cancer in General Adrenal Gland ... Vulva Childhood Cancer - Retinoblastoma
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    54. Retinoblastoma
    retinoblastoma is a rare cancer of the eye. It may be hereditary, and onethirdof the cases involve both eyes. Subscribe now . retinoblastoma.
    http://healthlink.mcw.edu/article/926232702.html
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    Retinoblastoma
    Retinoblastoma is a rare cancer of the eye. It may be hereditary, and one-third of the cases involve both eyes. Retinoblastoma often can be seen by looking at the young person's eye but is usually diagnosed by an examination under general anesthesia using an ophthalmoscope, an instrument used in examining the interior of the eye. The disease tends to remain localized for long periods, but in advanced stages, it can metastasize, or spread to other parts of the body. x-rays, bone marrow examination, MRI, and a bone scan can be done to check for metastases. If diagnosed early, it is possible to destroy the tumor with radiation therapy and preserve normal vision. If the tumor is so large that there is no hope of maintaining useful vision using radiation, the eye is removed. In cases where both eyes are involved, an attempt is made to preserve vision in both eyes through treatment with radiation. When advanced disease is found in both eyes, an attempt is made to preserve vision in at least one eye. Whenever there is any possibility of useful vision, all efforts are made to preserve it. Chemotherapy, radiation, or both may also be used to treat metastases. Information provided by the

    55. The Contact A Family Directory - RETINOBLASTOMA
    printer friendly, retinoblastoma, Further information on these resources can be foundin our Medical Information on the Internet article. retinoblastoma SOCIETY.
    http://www.cafamily.org.uk/Direct/r27.html
    printer friendly RETINOBLASTOMA home more about us in your area conditions information ... how you can help search this site Retinoblastoma is a malignant tumour which develops at the back of the eye. It originates in the cells of the retina, the light sensitive lining of the eye. It affects babies and young children and is very rare after the age of 5 years. Retinoblastoma may be unilateral (affecting one eye) or bilateral (both eyes involved). The unilateral form is more common and accounts for approximately 60% of all cases. However, when a unilateral tumour is diagnosed in very young children, particularly during the first year of life, a tumour may subsequently develop in the other eye so regular eye checks must be undertaken to detect any new tumours at an early stage. More than 95% of children with Retinoblastoma can be cured. Treatment of Retinoblastoma may include surgery, chemotherapy, laser therapy, freezing treatment, plaque or external beam radiotherapy. Often a combination of treatments is needed. If only one eye is affected, the child is likely to have normal vision in the other eye and will not need any special help at school. Where both eyes are affected, low vision aids are sometimes necessary to enable the child to attend a mainstream school.

    56. Retinoblastoma Foundation
    retinoblastoma Foundation. This response Murray. We have started theNational retinoblastoma Research and Support Foundation. If
    http://med-aapos.bu.edu/publicinfo/store1/RetinoblastomaFoundation.html
    Retinoblastoma Foundation
    This response submitted by Nicole Cicciarelli on 12/13/96.
    I am a coordinator for the Ocular Oncologist at Bascom Palmer, Dr. Timothy Murray. We have started the National Retinoblastoma Research and Support Foundation. If anyone is interested in receiving our newsletter or needs help with finding information of RB please contact me through E-mail address tmurray@mednet.med.miami.edu. or by calling me direct at 1-800-329-7000 ext. 6350.
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    57. Retinoblastoma
    retinoblastoma. Subject retinoblastoma Title retinoblastoma SupportNews Author(s) Journal retinoblastoma Support News Book Vol
    http://med-aapos.bu.edu/PediRef/retinoblastoma.html
    Retinoblastoma
    Subject: Retinoblastoma Title: Retinoblastoma Support News Author(s): Journal: Retinoblastoma Support News Book: Vol.: 5 (3) Date:Fall,1992 Pages: 1-9 Organization: The Institute for Families of Blind Children Address: P.O. Box 54700; Mail Stop #111 City: Los Angeles State: CA Z7ip: 90054-0700 Phone: (213) 669-4649 Type: Newsletter Subject: Retinoblastoma Title: Retinoblastoma Author(s): Joumal: Book: Vol.: Date: 1990 Pages: Organization: National Organization for Rare Disorders, Inc. Address: P.O. Box 8923; 100 Route 37 City: New Fairfield State: CT zip: 06812-1783 Phone: (203) 746-6518 Type: Fact sheets
    You can send E-Mail to the AAPOS Web Server directly from here. Please send comments and suggestions. You may also attach electronic files to e-mail. Please send us feedback
    Last Modified by Rick Blocker on 3/10/95
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    58. MEDLINEplus Enciclopedia Médica: Retinoblastoma
    Translate this page retinoblastoma. Definición Volver al comienzo. El retinoblastoma es un tumor maligno(cáncer) de la retina que generalmente afecta a niños menores de 6 años.
    http://www.nlm.nih.gov/medlineplus/spanish/ency/article/001030.htm
    Omita y vaya al Contenido
    Otros enciclopedia temas: A-Ag Ah-Ap Aq-Az B-Bk ... Z
    Retinoblastoma
    Contenido:
    El ojo Nombres alternativos Volver al comienzo Cáncer de retina; tumor de retina Definición Volver al comienzo El retinoblastoma es un tumor maligno (cáncer) de la retina que generalmente afecta a niños menores de 6 años. Causas, incidencia y factores de riesgo Volver al comienzo El retinoblastoma se presenta cuando una célula de la retina en crecimiento desarrolla una mutación en el gen RB (un gen supresor de tumor ). Esta mutación hace que la célula crezca sin control y se convierta en cáncer. Algunas veces, dicha mutación se desarrolla en un niño cuya familia nunca ha tenido cáncer en el ojo, pero otras veces, la mutación está presente en varios miembros de la familia. En este último caso, existe un 50% de posibilidades de que los hijos de la persona afectada también tengan la mutación y un alto riesgo de desarrollar un retinoblastoma. Uno o ambos ojos pueden estar afectados y se puede presentar una mancha blanquecina en la pupila. La

    59. MEDLINEplus Medical Encyclopedia: Retinoblastoma
    retinoblastoma.
    http://www.nlm.nih.gov/medlineplus/ency/article/001030.htm
    Skip navigation
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    Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z
    Retinoblastoma
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    Illustrations
    Eye Alternative names Return to top Tumor - retina; Cancer - retina Definition Return to top Retinoblastoma is a malignant tumor (cancer) of the retina (part of the eye) that generally affects children under the age of 6. Causes, incidence, and risk factors Return to top Retinoblastoma occurs when a cell of the growing retina develops a mutation in the RB gene (a tumor suppresser gene). This mutation causes the cell to grow out of control and become cancer. Sometimes this mutation develops in a child whose family has never had eye cancer, but other times the mutation is present in several family members. If the mutation runs in the family, there is a 50% chance that an affected person's children will also have the mutation and a high risk of developing retinoblastoma.
    One or both eyes may be affected. A visible whiteness in the pupil may be present. Blindness can occur in the affected eye, and the eyes may appear crossed. The tumor can spread to the eye socket, and to the brain, by means of the optic nerve. This is a rare tumor, except in families that carry the RB gene mutation.

    60. Retinoblastoma - HUM-MOLGEN
    We have cases and would like to start a project on retinoblastoma. Dear MadamMay I know what kind of project you already have on retinoblastoma.
    http://www.hum-molgen.de/bb/Forum2/HTML/000121.html

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    profile
    register preferences faq ... next oldest topic Author Topic: Retinoblastoma noushin Davoudi
    Member posted 12-18-2002 06:44 AM We have cases and would like to start a project on Retinoblastoma. If anyone is interested or have new idea we can go for it.
    Noushin Davoudi
    Ph.D. of Medical Biotechnology,
    Pasteur Institute Of Iran-Tehran IP: 195.146.34.249 imtiazshafiq
    Member posted 01-03-2003 11:43 AM Dear Madam
    May I know what kind of project you already have on Retinoblastoma. And aslo may i know have you collected the cases from a Single family? Same ethenic group? or from diverse population? Muhammad Imtiaz Shafiq Lecturer Institute of Biochemistry and Biotechnology University of the Punjab Lahore Pakistan. IP: 216.236.220.20 All times are ET (US) next newest topic next oldest topic Administrative Options: Close Topic Archive/Move Delete Topic Hop to: Select a Forum or Archive List of Forums: Biotechnical requests and sources DIAGnostics - Clinical Research (professional requests) Ethical, legal and social implications

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