61. Retinoblastoma retinoblastoma. 1. A Parent's Guide to Understanding retinoblastoma Ch. 1 - Whatis retinoblastoma? Ch. 4 - Genetics of 2. retinoblastoma - retinoblastoma. http://www.health-nexus.com/retinoblastoma1.htm

Health-Nexus.Net Health-Nexus.Org The #1 Health information site Home ... Retinoblastoma 11-20 Search Health-Nexus for: Match ALL words Match ANY word Email this page to a friend ! Post a question or comment on our Message Board Home Page Health Specialties Health News ... Alternative Health Options Substance Abuse Animal Health Search: Books Magazines Video Keywords: Find it Here Retinoblastoma A Parent's Guide to Understanding Retinoblastoma - Ch. 1 - What is Retinoblastoma? Ch. 2 - Structure and Function of the Eye; Ch.3 - Presenting Signs and Symptoms of Retinoblastoma; Ch. 4 - Genetics of ... Retinoblastoma - Retinoblastoma GeneClinics: Retinoblastoma - Describes the genetic connection to the development of retinoblastoma. OncoLink: Retinoblastoma - Primary document on OncoLink regarding retinoblastoma. www.retinoblastoma.com - Welcome to retinoblastoma.com. This page is currently under construction, but please see our guide for parents and check back periodically. David H. Abramson, MD Director, Ophthalmic Oncology Center Christopher M. Frank, AB Research Assistant New York Retinoblastoma - provides scientific information and images. Retinoblastoma Basics

62. Moved: The Retinoblastoma Page This page has moved to http//www.cancerindex.org/ccw/guide2r.htm.Please update your bookmarks. Sorry for any inconvenience. http://www.ncl.ac.uk/child-health/guides/guide2r.htm

This page has moved to: http://www.cancerindex.org/ccw/guide2r.htm Please update your bookmarks. Sorry for any inconvenience.

63. InteliHealth: Retinoblastoma crossreferenced in an AZ format. retinoblastoma. Health A to Z, Reviewedby the Faculty of Harvard Medical School retinoblastoma http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/10614.html

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64. Retinoblastoma & Miracles Benefit Homepage News • News • News •. Call retinoblastoma International Toll Free1888-353-008. Links • Links • Links •. retinoblastoma Pages. http://remarque.org/~sally/Miracles.html

document.write(''); Visitors since May 26th, 1998 [Page updated (16:30 PST) Friday, December 1st, 2000] Welcome If anyone has suggestions for improvements, new links, or related articles please e-mail the the page; or if you have information on related legitimate charities or benefits that you would like to advertise on the page. Sally A. Wilson, Sally e-mail: sally@remarque.org GoTo.com please utilize it for your web.net searches. GoTo pays 3 cents for every search; I have set it up that the money that the page makes will be donated to Retinoblastoma International, Children's Hospital Los Angeles. Article, Inside Soap Magazine Article, Inside Soap Magazine Actor Matthew Ashford talks about dealing with a child with Rb and his activism for Rb Awareness. Information on how to help a Sacramento Rb Survivor: Below is information concerning the Sacramento Bee newspaper's Book of Dreams , and how you can help Christina Parra.

65. Retinoblastoma retinoblastoma a cancer of the retina of the eye in children, inheritedas a dominant. retinoblastoma. Click Here. retinoblastoma http://www.webref.org/anthropology/r/retinoblastoma.htm

retinoblastoma Free T-Mobile Long Distance retinoblastoma: a cancer of the retina of the eye in children, inherited as a dominant. Source: Anthromorphemics Questia - The Online Library Back Next radioactive decay radiocarbon dating ... retina retinoblastoma retouch retouched flake retouching reverse face ... Tabularium™ WebRef™ Search WWW Search webref.org Digital River: Get amazing deals on great software! Iverson Software Co., 506 Genesis Ave., Marshall MN 56258-3110 Email WebMaster PRIVACY POLICY This site hosted by EASY CGI Web Hosting

66. Retinoblastoma Subscribe now . retinoblastoma. retinoblastoma is a rare cancer of theeye. It may be hereditary, and onethird of the cases involve both eyes. http://oci.mcw.edu/article/926232702.html

Search: search tips Email this article Print this article Find related articles: By topic: Cancer Children's Health Eyes By keywords: Receive Health Link via email! Subscribe now >> Retinoblastoma Retinoblastoma is a rare cancer of the eye. It may be hereditary, and one-third of the cases involve both eyes. Retinoblastoma often can be seen by looking at the young person's eye but is usually diagnosed by an examination under general anesthesia using an ophthalmoscope, an instrument used in examining the interior of the eye. The disease tends to remain localized for long periods, but in advanced stages, it can metastasize, or spread to other parts of the body. x-rays, bone marrow examination, MRI, and a bone scan can be done to check for metastases. If diagnosed early, it is possible to destroy the tumor with radiation therapy and preserve normal vision. If the tumor is so large that there is no hope of maintaining useful vision using radiation, the eye is removed. In cases where both eyes are involved, an attempt is made to preserve vision in both eyes through treatment with radiation. When advanced disease is found in both eyes, an attempt is made to preserve vision in at least one eye. Whenever there is any possibility of useful vision, all efforts are made to preserve it. Chemotherapy, radiation, or both may also be used to treat metastases. Information provided by the National Cancer Institute National Institutes of Health Home About HealthLink About MCW Contact Information ... Privacy

67. Retinoblastoma Bambi retinoblastoma AIGR Associazione Italiana genitori di bambini affettida retinoblastoma http//www.aigr.it/ http//web.tiscalinet http://fastnet.it/enti/bambi/retinoblastoma.htm

Retinoblastoma A.I.G.R. Associazione Italiana genitori di bambini affetti da retinoblastoma http://www.aigr.it/ http://web.tiscalinet.it/ambupedy/retinoblastoma.htm http://digilander.iol.it/retinoblastoma ... http://www.solutionsbysequence.com/frame_what_is_retinoblastoma.html u http://my.webmd.com/content/article/1680.51894 http://ask.oxygen.com/AnswerFinal.asp?Link=http://thriveonline.oxygen.com/me n=0 http://pubs.ama-assn.org/register.html http://my.webmd.com/content/article/1680.51895 http://my.webmd.com/content/article/1680.51896 http://www.drkoop.com/conditions/vision/library/retinoblastoma_stage.html ... The Eye Cancer Resources Directory BAMBI -INFORMAZIONI SULLE MALATTIE RARE DEI BAMBINI- E' ON LINE DAL 1997 E-mail ruffelli@tin.it

68. RETINOBLASTOMA CPMCnet. Cancer TYPES OF CANCER retinoblastoma. CAUSE retinoblastoma canbe caused by deletion or damage to both Rb genes on chromosome 13. http://cpmcnet.columbia.edu/texts/guide/hmg17_0017.html

Cancer TYPES OF CANCER RETINOBLASTOMA DEFINITION Retinoblastoma is a rare cancer of the retina that usually develops in children under the age of 3. About half of all cases are hereditary. Because "sporadic" cases result from new genetic mutations, siblings of patients should be examined periodically. When diagnosed and treated early, 80 percent of all cases can be cured. CAUSE Retinoblastoma can be caused by deletion or damage to both Rb genes on chromosome 13. Rb is a tumor-suppressor gene. If damaged or absent, cancers develop more readily. In familial cases, one chromosome already is inherited with the abnormal Rb gene and the other must be damaged to produce a tumor. In sporadic cases, both Rbs on chromosomes 13 in the same retinal cell become damaged. DIAGNOSIS Signs include crossed eyes (strabismus) or a yellow or white spot in the pupil. Inherited cases—about 50 percent of all cases—usually affect both eyes. The tumors often can be visualized by careful examination of the eye. A CT scan also may detect other small tumors in other parts of the eye. TREATMENT Treatment depends upon the extent of the cancer. One involved eye can be removed along with as much of the optic nerve as possible and the other eye examined periodically. If both eyes are involved, the one with the more extensive disease often will be removed and the other treated with laser surgery, freezing (cryotherapy), radiation, and chemotherapy in an effort to eliminate the cancer while preserving as much eyesight as possible.

69. Short Description Of Cell Lines. Tumor Retinoblastoma Version 4.200201, Short description of cell lines. Tumor retinoblastoma. By selecting the cell line name, you will receive the http://www.biotech.ist.unige.it/cldb/tum101.html

70. Retinoblastoma Eye. retinoblastoma. retinoblastoma is a malignant tumor of the retina.retinoblastoma What is retinoblastoma? retinoblastoma is http://jhhs.client.web-health.com/web-health/topics/GeneralHealth/generalhealths

71. Retinoblastoma retinoblastoma. When retinoblastoma is bilateral, enucleation is done onthe worst eye first, with radiotherapy attempted on the other eye. http://www.spedex.com/resource/documents/veb/retinoblastoma.html

RETINOBLASTOMA DESCRIPTION: A malignant and life-threatening intraocular tumor which appears in children; 2/3rds appear before age 3, however, rare cases have been reported at almost every age. About 30% are bilateral. It usually is unnoticed until it has progressed to a point of producing a white pupil (unless it has caused a strabismus and is diagnosed earlier, since blind eyes in children will often turn inward). Generally, the earlier the tumor is discovered, the better the chance to treat it and prevent its spread through the optic nerve and orbital tissues. About 94% of these tumors are due to mutations, but survivors will pass the mutated gene on about 50% of the time. TREATMENT: Enucleation is the treatment of choice when the tumor is large; radiotherapy and/or chemotherapy are other possibilities. Occasionally, cryotherapy or photocoagulation are effective. When retinoblastoma is bilateral, enucleation is done on the worst eye first, with radiotherapy attempted on the other eye. If no improvement is observed, enucleation is done on the second eye. GENETIC COUNSELING IS ESSENTIAL.

72. Retinoblastoma retinoblastoma. Topic(s) Ophthalmology , Cancer. Title overview. Intraocular,extraocular, and recurrent retinoblastoma are included. http://www.library.ucsf.edu/biosites/data/200.html

Home Latest 25 Resources Topic List Retinoblastoma Topic(s): Ophthalmology Cancer Title: Retinoblastoma Creator: Cancernet PDQ Location (URL): http://imsdd.meb.uni-bonn.de/cancernet/100993.html Provider: National Cancer Institute, U.S. Department of Health and Human Services Description: PDQ profiles Retinoblastoma, including definitions, stage information, cellular classification, and treatment options overview. Intraocular, extraocular, and recurrent retinoblastoma are included. Access Type: Web (http) MeSH: Retinoblastoma; Eye Neoplasms Publication Date: August 1996 ISBN/ISSN: Frequency : None/Not Applicable Submitted By: Stanford, mt Date Submitted:

73. Retinoblastoma retinoblastoma. age most 3 yrs, almost all 6 yrs; types familial(33%) aut. dominant, 67% bilateral; sporadic (67%). leukokoria http://chorus.rad.mcw.edu/doc/00700.html

CHORUS Collaborative Hypertext of Radiology Nervous system Feedback Search retinoblastoma types: familial (33%): aut. dominant, 67% bilateral sporadic (67%) leukokoria ("white reflex") may > osteosarcoma after RT CT: high density mass in globe usually Ca + no enhancement DDx: intraocular Ca + Charles E. Kahn, Jr., MD - 2 February 1995 Last updated 14 March 2001 Medical College of Wisconsin

74. OHSU Doernbecher - Oncology retinoblastoma, RELATED SERVICES. ·, Hematology/Oncology. What is retinoblastoma?retinoblastoma is a rare cancer of the retina. http://www.ohsuhealth.com/dch/health/oncology/retinoblastoma.asp

Oncology Home About Cancer Chemotherapy Bone Marrow Transplant ... Rhabdomyosarcoma Retinoblastoma Brain Tumors Hepatoblastoma Germ Cell Tumors Glossary ... Online Resources You have selected the following Health topic: - Adolescent Medicine - Burns - Cardiovascular Disorders - Care of the Terminally Ill Child - Children Having Surgery - Common Childhood Injuries and Poisoning - Craniofacial Anomalies - Dermatology - Diabetes - Eye Care - Genetics - Growth and Development - High-Risk Newborn - High-Risk Pregnancy - Immunizations - Infectious Diseases - Mental Health - Neurological Disorders - Normal Newborn - Oncology - Orthopaedics - The Pediatrician - Pregnancy and Childbirth - Respiratory Disorders - Transplantations - Well-Care Visits Retinoblastoma RELATED SERVICES Hematology/Oncology What is retinoblastoma? Retinoblastoma is a rare cancer of the retina. The retina is the innermost layer of the eye, located at the back of the eye, that receives light and images necessary for vision. About 200 children in the US are diagnosed with this type of cancer each year. It mostly occurs in children under the age of 5; the highest incidence of the disease occurs between infancy and age 2. Both males and females are affected equally. Retinoblastoma can occur in either eye, however, in about 25 to 30 percent of the cases, the tumor is present in both eyes. Retinoblastoma cells can, in rare cases, spread (metastasize) to other areas of the body, including the bone marrow. What causes retinoblastoma?

75. Children's Health At Doernbecher - Child Health A-Z retinoblastoma, RELATED SERVICES. ·, Ophthamology. ·, Hematology/Oncology.What is retinoblastoma? retinoblastoma is a rare cancer of the retina. http://www.ohsuhealth.com/dch/health/eye/retinoblastoma.asp

Eye Care Index Anatomy of the Eye Normal Vision Eye Care Specialists ... Keratitis Retinoblastoma Retinopathy of Prematurity Stye (Hordeolum) Problems With Vision Eye Trauma ... Online Resources You have selected the following Health topic: - Adolescent Medicine - Burns - Cardiovascular Disorders - Care of the Terminally Ill Child - Children Having Surgery - Common Childhood Injuries and Poisoning - Craniofacial Anomalies - Dermatology - Diabetes - Eye Care - Genetics - Growth and Development - High-Risk Newborn - High-Risk Pregnancy - Immunizations - Infectious Diseases - Mental Health - Neurological Disorders - Normal Newborn - Oncology - Orthopaedics - The Pediatrician - Pregnancy and Childbirth - Respiratory Disorders - Transplantations - Well-Care Visits Retinoblastoma RELATED SERVICES Ophthamology Hematology/Oncology What is retinoblastoma? Retinoblastoma is a rare cancer of the retina. The retina is the innermost layer of the eye. It is located at the back of the eye and receives light and images necessary for vision. About 200 children in the US are diagnosed with this type of cancer each year. It mostly occurs in children under the age of 5; the highest incidence of the disease occurs between infancy and age 2. Both males and females are affected equally. Retinoblastoma can occur in either eye; however, in about 25 percent of the cases, the tumor is present in both eyes. Retinoblastoma cells can, in rare cases, spread (metastasize) to other areas of the body, including the bone marrow.

76. Interactive Fly, Drosophila retinoblastomafamily protein Biological Overview Evolutionary Homologs Regulation Developmental Biology Effects of Mutation References http://sdb.bio.purdue.edu/fly/newgene/retnbls1.htm

Retinoblastoma-family protein Biological Overview Evolutionary Homologs Regulation Developmental Biology ... References Gene name - Retinoblastoma-family protein Synonyms - RBF Cytological map position - Function - transcription factor Keywords - cell cycle Symbol - Rbf FlyBase ID: Genetic map position - Classification - Retinoblastoma family Cellular location - presumably nuclear NCBI and GadFly links: Scaffold view Genomic region FASTA region GenPept ... GadFly BIOLOGICAL OVERVIEW In mammalian cells, the Retinoblastoma protein (RB) acts as a critical switch, regulating entry into the DNA synthetic phase (S phase) of the cell cycle . RB interacts with and negatively regulates members of a family of factors called E2Fs, which serve to activate transcription of genes required for entry into S phase. Phosphorylation of RB by cyclin/cyclin dependent kinases, the protein dimers that regulate the cell cycle, target RB for destruction, releasing E2F, thereby allowing E2F to carry out its function as a transcriptional activator. In mammals, RB is represented by a family of three closely related proteins: RB itself, p107 and p130. Drosophila Retinoblastoma-family protein (Rbf) was isolated by virtue of its ability to interact with E2F complexes containing Drosophila

77. Retinoblastoma retinoblastoma. Table of Contents. GENERAL INFORMATION. CELLULAR CLASSIFICATION. TREATMENTOPTION OVERVIEW. INTRAOCULAR retinoblastoma. Unilateral disease. http://www.uoc.muni.cz/guidelines/1deti/RETINOBL.htm

Retinoblastoma Table of Contents GENERAL INFORMATION CELLULAR CLASSIFICATION STAGE INFORMATION Intraocular Extraocular Reese-Ellsworth classification for intraocular tumors St. Jude Children's Research Hospital clinical staging system TREATMENT OPTION OVERVIEW INTRAOCULAR RETINOBLASTOM A Unilateral disease Bilateral disease EXTRAOCULAR RETINOBLASTOMA RECURRENT RETINOBLASTOMA GENERAL INFORMATION This treatment information summary on retinoblastoma is an overview of prognosis, diagnosis, classification, and treatment. The National Cancer Institute created the PDQ database to increase the availability of new treatment information and its use in treating patients. Information and references from the most recent published literature are included after review by pediatric oncology specialists. Cancer in children is rare. A team approach, incorporating the skills of the local physician, radiation therapists, pediatric medical oncologists/hematologists, rehabilitation specialists, and social workers, is imperative to ensure that patients receive the best treatment. In order for advances to be made in treating these patients, therapy is best delivered in the context of a clinical trial at a major medical center that has expertise in treating children. Only through entry of all eligible children into appropriate, well-designed clinical trials will progress be made against these diseases. Guidelines for pediatric cancer centers and their role in the treatment of pediatric patients with cancer have been outlined by the American Academy of Pediatrics.[1]

78. Teens Living With Cancer Retinoblastoma retinoblastoma If disease. What Is RB (it's not rhythm and blues!).retinoblastoma is a malignant (cancerous) tumor of the retina. http://www.teenslivingwithcancer.org/cancerFacts/whatIs/retinoblastoma.html

79. 1Up Health > Retinoblastoma > Causes, Incidence, And Risk Factors Of Retinoblast Comprehesive information on retinoblastoma (Cancer retina, Tumor - retina). retinoblastomaCauses, Incidence, and Risk Factors. Alternative names http://www.1uphealth.com/health/retinoblastoma_info.html

1Up Health Retinoblastoma Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Retinoblastoma Information Retinoblastoma Causes, Incidence, and Risk Factors Alternative names : Cancer - retina, Tumor - retina Definition : Retinoblastoma is a malignant tumor (cancer) of the retina (part of the eye) that generally affects children under the age of 6. Causes, Incidence, and Risk Factors Retinoblastoma occurs when a cell of the growing retina develops a mutation in the RB gene (a tumor suppresser gene). This mutation causes the cell to grow out of control and become cancer. Sometimes this mutation develops in a child whose family has never had eye cancer, but other times the mutation is present in several family members. If the mutation runs in the family, there is a 50% chance that an affected person's children will also have the mutation and a high risk of developing retinoblastoma. One or both eyes may be affected. A visible whiteness in the pupil may be present. Blindness can occur in the affected eye, and the eyes may appear crossed. The tumor can spread to the eye socket, and to the brain, by means of the optic nerve. This is a rare tumor, except in families that carry the RB gene mutation. Previous Next Jump to Another Section of this Guide Definition Causes, Incidence, and Risk Factors

80. Retinoblastoma retinoblastoma. eye033.jpg (60262 bytes). This cross section of the eyeball demonstratesa large white mass pushing into the vitreous. This is a retinoblastoma. http://medgen.genetics.utah.edu/photographs/pages/retinoblastoma.htm

retinoblastoma This cross section of the eyeball demonstrates a large white mass pushing into the vitreous. This is a retinoblastoma. This is what is seen as white on the fundusocopic examination. Retinoblastoma is one of the "small blue cell tumors" of childhood. Necrosis and dystrophic calcification are commonly seen within this tumor. At low magnification, two small calcification can be seen below center. Retinoblastoma is one of the "small blue cell tumors" of childhood. Necrosis and dystrophic calcification are commonly seen within this tumor. The characteristic microscopic pattern is arrangement of the small blue cells into Flexner-Wintersteiner "rosettes" as shown here. Examinations Photographs Movies Links ... noJava Home

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