61. MedWebPlus Web Site ID 9681 WebPath MiniTutorial. Pathology of systemic lupus erythematosus. http//www-medlib.med.utah.edu/WebPath/TUTORIAL/SLE/SLE.htmlUptime grade A. Usage grade http://www.medwebplus.com/obj/9681

62. Your Health Systemic Lupus Erythematosus YOUR HEALTH systemic lupus erythematosus sensitivity to sunlight. Symptoms ofsystemic lupus erythematosus may include joint pain and swelling; fever; http://www.calgaryhealthregion.ca/hlthconn/items/sle.htm

'Your Health' Home 'Your Health' Topics About This Site Dictionary ... Links YOUR HEALTH: Systemic Lupus Erythematosus Lupus erythematosus is a 'chronic' disease meaning that the symptoms come and go over time. We now recognize lupus as an 'auto-immune' disease. This means that the immune system, which normally protects the body from germs, abnormal cells and foreign substances, does not work properly. In an auto-immune disease, the immune system identifies its own cells as being abnormal or foreign and sends antibodies to attack the body's normal cells. The result is inflammation and scarring of the tissues involved. In lupus, the immune system specifically attacks the connective tissue that surrounds various parts and organs of the body. It causes inflammation and damage to a wide variety of body tissues the skin, joints, blood cells, kidneys and lungs as well as other organs and tissues. The exact cause of lupus is not known and, as yet, there is no cure. Heredity and genetic factors may make certain individuals more likely to develop the disease. It is thought that some factors, which normally stimulate the body’s immune system (such as a viral infection), may trigger the onset of the disease. Also, certain medications (particularly in elderly people), have been found to produce symptoms similar to lupus. Lupus has been found to be more common in women of child-bearing age for reasons not completely understood. The exact cause of lupus will likely be discovered when research has shed more light on the immune system as a whole.

63. Systemic Lupus Erythematosus: Comprehensive Online Library Of Resources Dealing CTRL+D will bookmark this page! systemic lupus erythematosus Online. Clickhere for alphabetical listing. Great Offers. 1. Magazine Subscriptions. http://www.autoimmune-disease.com/lupus_erythematosus.htm

CTRL D will bookmark this page! Systemic Lupus Erythematosus Online Click here for alphabetical listing Great Offers Magazine Subscriptions Office Supplies DVD Movies Music Clubs ... Understanding Autoimmune Disease from the National Institutes of Health. Scientific background on the causes of autoimmune diseases, written for a lay person. American Autoimmune Related Diseases Association Lupus Foundation of America National Women's Information Center: Info on Autoimmune disease Systemic Lupus Erythematosus from WebMD Systemic Lupus Erythematosus from National Institute of Arthritis and Musculoskeletal and Skin Diseases Essential Links to Medicine Treatment of Systemic Lupus Erythematosus: An Update from the American Academy of Family Physicians Lupus Resource Center from HealingWell Resources for Compassionate Care of Lupus (SLE) from Add a Link Search: All Products Books Popular Music Classical Music Video Toys Consumer Electronics Home Improvement Keywords: Please Support Our Sponsors Useful Links Online Dictionaries A comprehensive collection of all kinds of online dictionaries: you can find any English dictionary, language dictionary, slang dictionary, medical and law dictionaries among many others on this site. Wow!!!

64. Systemic Lupus Erythematosus For Medical Professionals only. systemic lupus erythematosus,, Printthis article, a connective systemic lupus erythematosus, Fig. 1 a http://www.amershamhealth.com/medcyclopaedia/Volume III 1/systemic lupus erythem

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Systemic lupus erythematosus, a connective tissue disorder characterized by significant immunological abnormalities and involvement of multiple organ systems, including the musculoskeletal system. Initial clinical manifestations most frequently include constitutional symptoms and signs (malaise, weakness, fever, anorexia and weight loss) and articular (polyarthritis) and cutaneous (skin rash) findings. Characteristic and significant musculoskeletal abnormalities in patients with systemic lupus erythematosus may include myositis , symmetric polyarthritis deforming nonerosive arthropathy , subchondral cysts , spontaneous tendon weakening and rupture, osteonecrosis , soft tissue calcification, osteomyelitis septic arthritis and miscellaneous other abnormalities.

65. Genesis Health System - Detailed Disease Info - Systemic Lupus Erythematosus systemic lupus erythematosus. systemic lupus erythematosus. In Harrison's Principlesof Internal Medicine, 14th ed., edited by Anthony S. Fauci, et al. http://www.genesishealth.com/micromedex/detaileddisease/00067210.aspx

Facility Information DeWitt Comm Hosp Genesis Medical Ctr Illini Hospital Genesis Health Grp VNA Systemic lupus erythematosus Systemic lupus erythematosus (SLE) is an autoimmune disease in which the individual's immune system attacks, injures, and destroys the body's own organs and tissues. Nearly every system of the body can be affected by SLE, as depicted in the illustration above. (Illustration by Electronic Illustrators Group.) Definition Systemic lupus erythematosus (also called lupus or SLE) is a disease where a person's immune system attacks and injures the body's own organs and tissues. Almost every system of the body can be affected by SLE. Description The body's immune system is a network of cells and tissues responsible for clearing the body of invading foreign organisms, like bacteria, viruses, and fungi. Antibodies are special immune cells that recognize these foreign invaders, and begin a chain of events to destroy them. In an autoimmune disorder like SLE, a person's antibodies begin to recognize the body's own tissues as foreign. Cells and chemicals of the immune system damage the tissues of the body. The reaction that occurs in tissue is called inflammation. Inflammation includes swelling, redness, increased blood flow, and tissue destruction. In SLE, some of the common antibodies that normally fight diseases are thought to be out of control. These include antinuclear antibodies and anti-DNA antibodies. Antinuclear antibodies are directed against the cell's central structure that contains genetic material (the nucleus). Anti-DNA antibodies are directed against the cell's genetic material. DNA is the chemical substance that makes up the chromosomes and genes.

66. JAMA -- Page Not Found 285;650652, February 7, 2001, Research Advances in systemic lupus erythematosus,Robert P. Kimberly, MD. Mortality studies in systemic lupus erythematosus. http://jama.ama-assn.org/issues/v285n5/ffull/jsc00515.html

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67. Systemic Lupus Erythematosus Arthritis On Medbroadcast.com systemic lupus erythematosus, (Lupus) causes inflammation in joints, tendonsand other connective tissues and organs. systemic lupus erythematosus. http://www.medbroadcast.com/health_topics/health_conditions/arthritis/index.shtm

68. Trends In Deaths From Systemic Lupus Erythematosus --- United States, 1979--1998 Trends in Deaths from systemic lupus erythematosus United States, 19791998. Mortalityand causes of death in systemic lupus erythematosus. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5117a3.htm

Trends in Deaths from Systemic Lupus Erythematosus - United States, 19791998 Systemic lupus erythematosus (SLE) is a serious autoimmune disease of unknown etiology that can affect several organs. Because SLE affects connective tissues and because painful joints and arthritis are among its most common manifestations, this disease is classified with arthritis and other rheumatic diseases ( ). SLE is one of the more fatal forms of rheumatic diseases and non-Causcasian race is a risk factor for death from SLE; however, trends in death from SLE have not been analyzed recently. To characterize deaths from SLE, CDC reviewed SLE deaths during 19791998. This report presents the results of that analysis, which indicate that marked age-, sex-, and race-specific disparities exist in SLE death rates and that death rates have increased by approximately 70% during the study period among black women aged 4564 years. Prevention of deaths requires early recognition and diagnosis of SLE and appropriate therapeutic management. The analysis used National Center for Health Statistics Multiple Cause-of-Death Public Use Data Tapes for 19791998. These national mortality statistics were based on data from death certificates filed in state vital statistics offices. Demographic data (e.g., age and race/ethnicity) listed on death certificates were reported by funeral directors, usually from information provided by the decedent's family. Causes of death listed on death certificates were reported by a physician, medical examiner, or coroner by using a format specified by the World Health Organization and endorsed by CDC. An SLE death was defined as any death of a U.S. resident coded with an underlying cause of death of systemic lupus erythematosus (

69. National Jewish-SYSTEMIC LUPUS Erythematosus BYTES Search our website, systemic lupus erythematosus BYTES. Approximately1.4 million people in the United States have lupus; Several thousand http://www.njc.org/lupusbytes.html

SYSTEMIC LUPUS Erythematosus BYTES Approximately 1.4 million people in the United States have lupus Several thousand people die from the disease each year. Lupus is mostly diagnosed in women, 16-45 years old Symptoms include achy and swollen joints, fever over 100 degrees, prolonged or extreme fatigue, skin rashes and anemia The disease affects the skin, joints, blood and kidneys and other organ systems of the body The immune system mistakenly attacks its own cells and tissues Following diagnosis and treatment, up to 90 percent of people with disease can lead a normal life Treatments include: Using nonsteroidal anti-inflammatory drugs such as ibuprofen or acetaminophen for pain Corticosteroids to reduce inflammation and help regulate the immune system Anti-malarial drugs to help with skin and joint symptoms Cytotoxic drugs to suppress inflammation and the immune system There Are Three Types of Lupus: Discoid lupus is diagnosed by examining a skin biopsy of the rash associated with the disease. Discoid usually does not involve the body's internal organs Systemic lupus can affect nearly any organ system of the body, including the skin, joints, kidneys, blood and lungs

70. HON Mother & Child Glossary, Systemic Lupus Erythematosus And Pregnancy .......HON Mother Child Glossary, systemic lupus erythematosus and Pregnancy. SystemicLupus Erythematosus and Pregnancy. http://www.hon.ch/Dossier/MotherChild/preexisting_conditions/lupus.html

Introduction Reproduction Pregnancy During Pregnancy ... Glossary A-Z During Pregnancy Pre-existing Conditions During Pregnancy Prematurity Problems Pregnancy Procedures External survey "Questionnaire on mood" conducted by the "IMSP- Faculty of Medicine - University of Geneva" Systemic Lupus Erythematosus and Pregnancy Description Systemic lupus erythematosus (SLE), or simply lupus, is a complex, chronic condition that affects the skin and connective tissue, blood, cardiovascular and nervous systems and the kidneys. It is an autoimmune disease where the immune system, which normally helps destroy foreign invaders, seems to turn against itself and attack healthy tissue in the body. Signs and symptoms that are common to this illness include: generalised discomfort, muscle aches, fatigue, fever, joint inflammation, rash, blood cell changes, sensitivity to sunlight, hair loss, kidney problems, depression. SLE and Pregnancy The chances of having a normal pregnancy and favourable delivery are generally good especially if the illness is under good control at the start of pregnancy. Lupus symptoms may improve during pregnancy, but may become more active again after the delivery. Some of the drugs that are used to treat this condition are safe to use during pregnancy, while others can not be used. Women with SLE are at higher risk of developing pre-eclampsia Slow foetal growth can occur. This can be detected by

71. HONselect - Lupus Erythematosus, Systemic Lupus Erythematosus, Systemic. Accepted term(s) Libman-Sacks Disease -Lupus ErythematosusDisseminatus -systemic lupus erythematosus -Disease, Libman-Sacks. http://www.hon.ch/HONselect/Selection/C17.300.480.html

HONselect: Introduction Search Browse Favourites List of Rare Disease add HONselect Contents on "Lupus Erythematosus, Systemic": MeSH hierarchy and definition Research Articles Web resources Medical Images Medical News Medical Conferences Clinical Trials Wondering about the holiday blues! MeSH Hierarchy English French German Spanish Portuguese MeSH Broader term(s) Diseases Immunologic Diseases Autoimmune Diseases Diseases Skin and Connective Tissue Diseases Connective Tissue Diseases Lupus Erythematosus, Systemic MeSH definition A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Subheadings : complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy MeSH Narrow term(s) Lupus Nephritis Lupus Vasculitis, Central Nervous System

72. Cogprints - Systemic Lupus Erythematosus In African-American Women: Immune Cogni systemic lupus erythematosus in AfricanAmerican women immune cognitivemodules, autoimmune disease, and pathogenic social hierarchy. http://cogprints.ecs.soton.ac.uk/archive/00002684/

Cogprints Home About Browse Search ... Help Systemic lupus erythematosus in African-American women: immune cognitive modules, autoimmune disease, and pathogenic social hierarchy Wallace, Rodrick (2003) Systemic lupus erythematosus in African-American women: immune cognitive modules, autoimmune disease, and pathogenic social hierarchy. Full text available as: PDF - Requires Adobe Acrobat Reader or other PDF viewer. Abstract Examining elevated rates of systemic lupus erythematosus in African-American women from the perspective of the emerging theory of immune cognition suggests the disease constitutes an internalized physiological image of external patterns of psychosocial stress, a 'pathogenic social hierarchy' involving the synergism of racism and gender discrimination. The disorder represents the punctuated resetting of 'normal' immune self-image to a self-attacking 'excited' state, a process formally analogous to models of punctuated equilibrium in evolutionary theory. We speculate that this punctuated onset takes place in the context of an immunological 'cognitive module' similar to what has been proposed by evolutionary psychologists for the human mind. We discuss the broader implications of a high rate of this disorder within a marginalized population, finding it to be a leading indicator for phenomena likely to entrain powerful subgroups into a larger pattern of embedding pathology Keywords: chronic inflammation, circadian cycle, cognitive module, immune cognition, lupus, racism, social hierarchy

73. University Of Miami School Of Medicine - Glossary - Systemic Lupus Erythematosus Diseases and Conditions. systemic lupus erythematosus.systemic lupus erythematosus (SLE or LUPUS). http://www.med.miami.edu/patients/glossary/art.asp?ArticleKey=491

74. Arthritis & Other Rheumatic Diseases - Lupus - Methodist Health Care System, Hou systemic lupus erythematosus (Lupus). http://www.methodisthealth.com/arthritis/lupus.htm

La Artritis y Otras Enfermedades Reumáticas (en español) Clinical Services The Methodist Hospital Diagnostic Center for Bone and Joint Replacement Methodist Sugar Land Hospital ... Appointment Systemic Lupus Erythematosus (Lupus) What is lupus? Systemic lupus erythematosus, also known as SLE, or, simply, lupus, is a disease that is characterized by periodic episodes of inflammation of and damage to the joints, tendons, other connective tissues, and organs, including the heart, lungs, blood vessels, brain, kidneys, and skin. The heart, lungs, kidneys, and brain are the organs most affected. Lupus affects each individual differently and the effects of the illness range from mild to severe. Lupus can potentially be fatal. The majority of people who have lupus are young women (late teens to 30s). This may be due to the fact that estrogen (a female hormone) seems to be associated with lupus. Lupus affects more African-Americans than Caucasians, Asian Americans, Latinos, or Native Americans in the US. Lupus in children occurs most often at the age of 10 and older; lupus is rare in children younger than 5 years of age. The disease is known to have periods of flare-ups and periods of remission (partial or complete lack of symptoms). Children with lupus can have a large degree of kidney involvement. The severity of the kidney involvement can alter the survival rate of patients with lupus. In some cases, kidney damage is so severe it leads to kidney failure.

75. Systemic Lupus Erythematosus systemic lupus erythematosus. If complement is turned against normal cells as inthe case of systemic lupus erythematosus, severe tissue damage may result. http://www.diseasedir.org.uk/disorder/dis05.htm

Systemic Lupus Erythematosus Disease Type: Autoimmune Disease Sub-Type: Systemic Underlying effects Autoantibodies are produced for a wide range of self Antigens, such as DNA, histones (protein coat of DNA) Red Blood Cells, platelets, leukocytes, and clotting factors. Which causes the activation of complement (resulting in Cell lysis). Complement is a series of blood serum proteins whose main function is to lyse invading non-cells. If complement is turned against normal cells as in the case of Systemic Lupus Erythematosus, severe tissue damage may result. Aetiology Unknown, but may involve some of these factors: (This is for Autoimmunity in general) Genetic Family Studies In identical twins only about 50% are both affected, in non-identical twins only 5% are both affected. Human Leukocyte Antigens (HLA), (also MHC) Some types of HLA, if present, increase the likelihood of the disease appearing. Gender Female susceptibility is 3 times greater than for males, hinting at a hormonal link. Environmental agents Bacteria Especially the 'Group A' Streptococci, which seem to cause Rheumatic heart disease.

76. Systemic Lupus Erythematosus systemic lupus erythematosus systemic lupus erythematosus (SLE), commonly knownas Lupus, is a very old disease and was first named 135 years ago. http://www.mcgill.ca/hostres/diseases/lupus/

Prospective students Student information Alumni and friends Faculty and staff ... Septic shock Systemic lupus erythematosus Tuberculosis Information for students Research partners Communications ... Training Centre Systemic lupus erythematosus Systemic lupus erythematosus (SLE), commonly known as Lupus, is a very old disease and was first named 135 years ago. It got its name from the very distinctive facial rash that gives a person the appearance of having been attacked by a wolf. The facial rash, which is also known as a butterfly rash, can occur after exposure to sunlight. This, however, is only one of the many different features of this autoimmune disease, which can affect almost every organ system. Lupus has been referred to as the disease with 1,000 faces. Lupus is relatively rare, affecting approximately 1 per 1,000, of whom 95% are women. It is more common in Africans, American Indians and Asians than in Caucasians. The disease can occur at any age, but typically starts in 20- to 30-year-old individuals. What causes the disease is unknown; however, many genes as well as the environment likely contribute to susceptibility and disease course. Of all of the autoimmune diseases, Lupus is the prototypic autoantibody-mediated disease. Circulating in patients with Lupus are antibodies to many different cellular components of the body, including DNA. When they bind to the self-components these autoantibodies can trigger events that lead to inflammation and the typical redness (the meaning of the word erythematosus). SLE is a very challenging disease for the patient to cope with (for more information see the

77. Arthritis: Systemic Lupus Erythematosus systemic lupus erythematosus (SLE) New Treatments for Mild and Severe Elena Peeva,MD, M.Sc., Gisele ZandmanGoddard, MD, and Peter Barland, MD Dr. Peeva is an http://www.thedoctorwillseeyounow.com/articles/arthritis/sle_7/

IN THIS ARTICLE Treatment of Mild SLE Emerging Therapies Severe SLE New Rx for Severe SLE A diet high in cholesterol raises your chance of developing gallstones. more... OTHER TOPICS COX 2 Fibromyalgia Smoking Systemic Lupus Erythematosus (SLE) New Treatments for Mild and Severe Elena Peeva, M.D., M.Sc., Gisele Zandman-Goddard, M.D. , and Peter Barland, M.D. Dr. Peeva is an Instructor of Medicine and Attending Physician at the Albert Einstein College of Medicine and Attending Physician at Montefiore Medical Center, NY, and Dr. Zandman-Goddard is an Instructor of Medicine and Attending Physician at Sheba Medical Center, Israel. Mild SLE Not long ago, systemic lupus erythematosus (SLE) was thought to be fatal in nearly all cases. Few SLE patients lived much longer than five years after being diagnosed. In recent decades, thankfully, the outlook for those with SLE has brightened. According to the latest figures, more than 80% of those diagnosed with SLE will survive more than ten years and many will enjoy a normal life span. We have made dramatic progress against SLE because potent new antibiotics are available to combat and prevent the serious and unusual infections that may complicate SLE. In addition, more effective corticocosteroids and immunosuppressive drugs now enable treatments for the various kinds of organ damage that SLE can cause. A good example is end stage renal disease, a potentially fatal kidney condition, which can be managed with improved dialysis and kidney transplant techniques. Finally, better diagnostic tests are helping doctors detect SLE earlier and identify milder forms of SLE that in the past would have been missed.

78. Systemic Lupus Erythematosus systemic lupus erythematosus Alternative Names lupus Definition systemic lupus erythematosus,OR SLE, is an autoimmune disorder that affects many parts of the http://atoz.iqhealth.com/HealthAnswers/encyclopedia/HTMLfiles/1787.html

systemic lupus erythematosus Alternative Names lupus Definition Systemic lupus erythematosus, OR SLE, is an autoimmune disorder that affects many parts of the body. An autoimmune disorder is a condition in which the body creates antibodies against its own tissues. What is going on in the body? A person with SLE produces antibodies against many of his or her own tissues. This autoimmune reaction can damage many parts of the body. These include: brain and nervous system digestive system eyes heart joints and muscles kidney lung skin What are the signs and symptoms of the disease? Because SLE affects so many different parts of the body, the disease has many signs and symptoms. These are best listed by organ system. Signs and symptoms that affect the whole body: fatigue fever loss of appetite nausea ... weight loss Signs and symptoms that affect the skin: hives loss of scalp hair red "butterfly rash" on the face, which extends over the cheeks and bridge of the nose in the shape of a butterfly red, raised rashes in areas exposed to the sun sensitivity to the sun ulcers of the mouth, nose, or vagina

79. European Lupus Erythematosus Federation Lupus in internet Further informations about systemic lupus erythematosus and relatedtopics in internet. MednetRheuma SLE - systemic lupus erythematosus. http://www.elef.rheumanet.org/

E UROPEAN L UPUS E RYTHEMATOSUS F EDERATION Welcome to the home page of ELEF ! Survey What is Lupus? History of ELEF Aims of ELEF ELEF addresses (Register) Official Addresses and further informations about ELEF and the members of ELEF, the national organisations of Lupus Groups in Europe. "Caring And Sharing" The Newsletter of ELEF is published twice a year. Lupus in internet Further informations about systemic lupus erythematosus and related topics in internet. Mednet-Rheuma Please send questions or comments to elef@rheumanet.org Converted to HTML by Team-RheumaNet WHAT IS LUPUS? So few have heard of it, yet worldwide it's seen as more common than leukaemia muscular dystrophy and multiple sclerosis. 90% of the patients who suffer from Lupus are female of childbearing age. Even young children can be affected by lupus. Lupus is a condition whereby the body's defence mechanism goes into overdrive and starts to attack itself. The symptoms are many and varied, and the illness often seems to mimic other diseases. This gives rise to difficulty in diagnosis and the condition can be overlooked, sometimes for years, unless the General Practioner or consultant is alert to the possibility of lupus. LUPUS IS NOT CONTAGIOUS Lupus can be triggered - at puberty - during the menopause - after childbirth - after viral infection - through sunlight - as a result of trauma - after a prolonged course of medication THE SYMPTOMS These may include - extreme fatigue - joint and muscle pain - eye problems - depression

80. Systemic Lupus Erythematosus: The Disease And Its Patients systemic lupus erythematosus The disease and its Patients. Jon Russell,MD, PHD, Health Science Center, University of Texas San Antonio, TX. http://www.elef.rheumanet.org/newsletter/6/systemic.htm

Systemic Lupus Erythematosus: The disease and its Patients Jon Russell, MD, PHD, Health Science Center, University of Texas San Antonio, TX A selection from the Lupus Foundation of America Newsletter Article Library "What is SLE?" Some of you have recently heard yourself ask that questions. I have WHAT? What is Lupus? Other of you have known of that diagnosis for many years, but still meet such questions in conversation with friends or acquaintances. Systemic Lupus Erythematosus (SLE) is a relatively uncommon autoimmune disorder in which the body=s immune forces are turned against ist own tissues and organs. The normal immune system is composed of several different forms of white blood cells which normally circulate in the bloodstream and take up residence in such organs as the spleen and lymph nodes. Their normal function is to recognize and destroy foreign invaders, such as bacteria, which are constantly attempting to gain access. A complex identification system exists which allows these cells to recognize the difference between the body=s normal cells, called self, from those foreign invaders, called non-self. Self-tissues are not normally attacked because they are recognized as belonging there. The problem in Lupus, we believe, is that the fail-safe mechanism, at times, is bypassed. The guardians of the body=s internal peace and safety, the white blood cells, get their identification signals confused and turn their destructive powers on the body=s own tissues because they see them as being foreign. It is as if the National Guard were to become confused in scattered parts of our country, and begin to attack our own citizens, as if they were all agents of the enemy.

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