1. Stanley B. Prusiner Winner Of The 1997 Nobel Prize In Medicine stanley B. prusiner, a nobel Prize Laureate in Physiology and Medicine,at the nobel Prize Internet Archive. stanley B. prusiner. http://almaz.com/nobel/medicine/1997a.html

S TANLEY B P RUSINER 1997 Nobel Laureate in Medicine for his discovery of Prions - a new biological principle of infection. Background Born: May 28, 1942 Place of birth: U.S.A. Residence: San Francisco, U.S.A. Affiliation: Department of Neurology, University of California, School of Medicine, San Francisco, CA 94143, USA Book Store Books by Stanley B Prusiner Prion Biology and Diseases (Cold Spring Harbor Monograph Series, No. 38) Books on Prion Diseases Books on Alzheimer's Disease Books on Kuru Books on Neuropathology ... Books on Neurodegenerative Diseases Featured Internet Links Official award announcement and background Illustrated Presentation Biography Curriculum Vitae ... DC Gajdusek and BS Blumberg 1976 Nobel Prize winning research on kuru PubMedline search results for this laureate PubMedline search results for prions Search WWW Search The Nobel Prize Internet Archive Links added by Nobel Internet Archive visitors A backgrounder on prions in the context of the Mad Cow Disease The Official Mad Cow Disease Home Page National Institute of Neurological Disorders and Stroke Scientific American prion article by Dr. Prusiner (submitted by Bob Hadsell CNN coverage of Dr. Prusiner's prizewinning experience

2. Index Of Nobel Laureates In Medicine ALPHABETICAL LISTING OF nobel PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE.Name, Year Awarded. Porter, Rodney R. 1972. prusiner, stanley B. 1997. http://almaz.com/nobel/medicine/alpha.html

ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE Name Year Awarded Adrian, Lord Edgar Douglas Arber, Werner Axelrod, Julius Baltimore, David ... Medicine We always welcome your feedback and comments

3. Medicine 1997 Presentation stanley B. prusiner Autobiography Curriculum Vitae BanquetSpeech nobel Diploma Prize Award Photo Other Resources. 1996, 1998. http://www.nobel.se/medicine/laureates/1997/

The Nobel Prize in Physiology or Medicine 1997 "for his discovery of Prions - a new biological principle of infection" Stanley B. Prusiner USA University of California San Francisco, CA, USA b. 1942 The Nobel Prize in Physiology or Medicine 1997 Press Release Presentation Speech Illustrated Presentation ... Other Resources The 1997 Prize in: Physics Chemistry Physiology or Medicine Literature ... Economic Sciences Find a Laureate: Last modified June 16, 2000 The Official Web Site of The Nobel Foundation

4. Stanley B. Prusiner - Autobiography stanley B. prusiner – Autobiography. My history is not atypical sucha project has demanded. From Les Prix nobel 1997. http://www.nobel.se/medicine/laureates/1997/prusiner-autobio.html

My history is not atypical of many Americans: born in the midwest, educated in the East, and now living in the West. My early years were shared between Des Moines, Iowa and Cincinnati, Ohio. Shortly after I was born on May 28, 1942 in Des Moines, my father, Lawrence, was drafted into the United States Navy. I was named for my father's younger brother who died of Hodgkin's disease at the age of 24. We moved to Boston briefly where my father enrolled in Naval officer training school before being sent to the south Pacific. He served as a communications officer for the remainder of World War II on an island called Eniwetok where the first hydrogen bomb was detonated a decade later. During my father's absence, my mother, Miriam, and I lived in Cincinnati where her mother, Mollie Spigel, also lived. Prior to moving to Cincinnati, Mollie had lived in Norfolk, Virginia, where she raised three children after her husband Benjamin was killed at age 50 in a traffic accident. Besides many special memories of my maternal grandmother, I have many fond reminiscences of my paternal grandfather, Ben, who emigrated to the United States in 1896 as a young boy from Moscow. He grew up in Sioux City, Iowa, as did my father with many other Russian Jews. Shortly after the end of World War II, we returned to Des Moines where I attended primary school and my brother, Paul, was born. In 1952, we moved back to Cincinnati with the hope that my father would be able to find a much better job as an architect. In Cincinnati, he practiced architecture for the next 25 years, which enabled him to provide a very comfortable home for his family.

5. Long-Time NIH Grantee Stanley B. Prusiner Wins Nobel Prize Overview stanley B. prusiner, MD, a longtime grantee of the National Institutesof Health (NIH), is the recipient of the 1997 nobel Prize in physiology or http://www.ninds.nih.gov/news_and_events/pressrelease_prions_100697.htm?type=arc

6. NINDS - News And Events Press Releases LongTime NIH Grantee stanley B. prusiner Wins nobel Prize Monday,October 06, 1997 stanley B. prusiner, MD, a long-time grantee of the National http://www.ninds.nih.gov/health_and_medical/news.htm?url=/health_and_medical/dis

7. NEUROSCIENCE : Stanley Prusiner stanley prusiner, MD Molecular Biological, Genetic and Protein Structural Studiesof Prion Disease. email. prusiner, SB Prions. In Les Prix nobel 1997, pp. http://www.ucsf.edu/neurosc/faculty/neuro_prusiner.html

Stanley Prusiner, MD Molecular Biological, Genetic and Protein Structural Studies of Prion Disease email unavailable phone office location Box 0518, HSE-774 other websites PIBS website Research Summary Current Projects Lab Personnel ... Publications Unavailable. Only current lab members are listed below. Click on the icon to open a list of former lab members. Unavailable. Only selected publications are listed below. Click on the icon to open a complete list of publications. Prusiner, S.B.: Prions. In Les Prix Nobel 1997, pp. 262-323, 1998. Nobel Foundation, Stockholm, Sweden. Reprinted in Proc. Nat. Acad. Sci. USA 95:13363-13383, 1998. Viles, J.H., Cohen, F.E., Prusiner, S.B., Goodin, D.B., Wright, P.E., Dyson, H.J.: Copper binding to the prion protein: structural implications of four identical cooperative binding sites. Proc. Natl. Acad. Sci. USA 96:2042-2047, 1999. Supattapone, S., Bosque, P., Muramoto, T., Wille, H., Aagaard, C., Peretz, D., Nguyen, H.-O. B., Heinrich, C., Torchia, M., Safar, J., Cohen, F.E., DeArmond, S.J., Prusiner, S.B., Scott, M.: Prion protein of 106 residues creates an artificial transmission barrier for prion replication in transgenic mice. Cell 96:869-878, 1999.

8. DAYBREAK - Nobel Prize For Prusiner stanley B. prusiner, MD, UCSF professor of neurology and biochemistry and biophysics,was awarded the nobel Prize in Physiology or Medicine yesterday. http://www.ucsf.edu/daybreak/1997/10/1006_nob1.htm

Visit UCSF Today at http://www.ucsf.edu/today/ NOBEL PRIZE FOR PRUSINER Stanley B. Prusiner, MD, UCSF professor of neurology and biochemistry and biophysics, was awarded the Nobel Prize in Physiology or Medicine yesterday. Prusiner received the prize “for his pioneering discovery of an entirely new genre of disease-causing agents and the elucidation of the underlying principles of their mode of action," according to the Nobel committee in Stockholm, Sweden. Prusiner discovered an entirely new disease agent, called a prion, which is implicated in rare, slowly progressing brain diseases. Prion Protein Model (Andrew Wallace) High Resolution Image available (79K) This illustration compares a normal prion protein to a disease-causing form. The two structures exhibit two different, classic protein motifs, called "alpha helices," and "beta sheets." Alpha helices, seen here in the normal prion (left), consist of linked amino-acid building blocks that spiral around like a coiled spring. Beta sheets form when amino acid chains line up in a flat plane within the protein, as in the disease-causing protein shown here. Research discoveries by Stanley Prusiner, MD, Fred Cohen, MD, PhD, and their UCSF colleagues suggest that the propagation of infectious prions arises from a rearrangement of a normal prion protein into a disease-causing form, a process that can be spurred by the initial presence of the infectious protein.

9. Long-Time NIH Grantee Stanley B. Prusiner Wins Nobel Prize Content for this page. LongTime NIH Grantee stanley B. prusiner Wins NobelPrize. For release Monday, October 06, 1997. Back to menu. Overview. http://accessible.ninds.nih.gov/news_and_events/pressrelease_prions_100697.htm?t

10. NIH Press Release - Long-Time NIH Grantee Stanley B. Prusiner Wins Nobel Prize - FOR IMMEDIATE RELEASE Monday, October 6, 1997, Marian Emr Natalie Larsen (301)4965751. Long-Time NIH Grantee stanley B. prusiner Wins nobel Prize. http://www.nih.gov/news/pr/oct97/ninds-06.htm

NATIONAL INSTITUTES OF HEALTH National Institute of Neurological Disorders and Stroke FOR IMMEDIATE RELEASE Monday, October 6, 1997 Marian Emr Natalie Larsen Long-Time NIH Grantee Stanley B. Prusiner Wins Nobel Prize Stanley B. Prusiner, M.D., a long-time grantee of the National Institutes of Health (NIH), is the recipient of the 1997 Nobel Prize in physiology or medicine for his discovery of an unusual class of infectious particles called prions. Prions are believed to be responsible for a group of diseases that include "mad cow" disease. Prusiner, who is professor of neurology, virology, and biochemistry at the University of California, San Francisco (UCSF), has received more than 56 million dollars in research grant support from NIH during the last three decades. "Dr. Prusiner is a pioneer in science and medicine. He introduced a truly new idea to the biology of disease... the idea that a protein can be an infectious agent," says Zach W. Hall, Ph.D., Director of the National Institute of Neurological Disorders and Stroke (NINDS), which has supported Dr. Prusiner since 1975. "His work has turned a once obscure corner of medicine into an important source of new ideas about fundamental biological mechanisms." Dr. Prusiner has received additional funding from the National Institute on Aging, the National Center for Research Resources, and the National Institute of General Medical Sciences, all of which are components of NIH. Dr. Prusiner led the work that uncovered the nature of prions (a term he coined from "

11. Nobel Laureates - 7. Lectures And Nobel Laureates - NIH 1998 Almanac Content nobel Laureates. Laureate, Field, Year, Supporting Institute(s). stanley B.prusiner, USA, Phyisology or medicine, 1997, NINDS, NIA, NCRR, NIGMS. http://www.nih.gov/about/almanac/1998/lectures/nobel.html

NIH 1998 Almanac Lectures and Nobel Laureates Nobel Laureates Laureate Field Year Supporting Institute(s) Paul D. Boyer, U.S.A. (shared with J.C. Skou) Chemistry NIGMS, NIDDK Jens C. Skou, Denmark (shared with P.D. Boyer) ......do NINDS Stanley B. Prusiner, U.S.A. Phyisology or medicine NINDS, NIA, NCRR, NIGMS Edward B. Lewis, U.S.A. (shared with C. Nusslein-Volhard, Germany, and E.F. Wieschaus, U.S.A.) Physiology or medicine NICHD, NIGMS Eric F. Wieschaus, U.S.A. (shared with E.B. Lewis, U.S.A., and C. Nusslein-Volhard, Germany) ......do NICHD Alfred G. Gilman, U.S.A. (shared with M. Rodbell, U.S.A.) .....do NIGMS, NINDS Martin Rodbell, U.S.A. (shared with A.G. Gilman, U.S.A.) ......do NIEHS, NIDDK George A. Olah, U.S.A. Chemistry NCI, NIGMS Phillip A. Sharp, U.S.A. (shared with R. Roberts, U.K.) Physiology or medicine NIGMS, NCI, NIAID, DRS, NCRR Richard Roberts, U.K. (shared with P.A. Sharp, U.S.A.) ......do NCRR, NLM, NCHGR, NCI, NIGMS Kary B. Mullis, U.S.A. (shared with M. Smith, Canada) Chemistry NHLBI, NIAID, NIGMS

12. Stanley B. Prusiner - CIRS prusiner, stanley B. stanley@itsa.ucsf.edu Research interests stanley prusinerdiscovered an entirely new class of Tokyo, Japan, 1996 The nobel Prize in http://www.cirs.net/researchers/medicine/PRUSINER.htm

PRUSINER, STANLEY B. stanley@itsa.ucsf.edu Professor of Neurology and Biochemistry and Biophysics at the University of California , San Francisco, CA, USA Research interests : Stanley Prusiner discovered an entirely new class of pathogens that replicate without nucleic acid. Through this work, he created a new field of research that has resulted in significant progress in understanding degenerative diseases of the central nervous system (CNS). His revolutionary studies have made conceptual advances in elucidating mechanisms of age-dependent CNS diseases. Awards : - Potamkin Prize for Alzheimer's Disease Research, American Academy of Neurology, 1991 - Christopher Columbus Quincentennial Discovery Award in Biomedical Research, NIH, 1992 Metropolitan Life Foundation Award for Medical Research, 1992 - Dickson Prize for Distinguished Scientific Accomplishments, University of Pittsburgh, 1992 - Charles A. Dana Award for Pioneering Achievements in Health, 1992 - Richard Lounsbery Award for Extraordinary Scientific Research, NAS, 1993 - Gairdner Foundation Award for Outstanding Achievement in Medical Science, 1993

13. TwURL Details Stanley B. Prusiner Winner Of The 1997 Nobel Prize Books by stanley B prusiner ~~~ (Virtual) http//www CNN coverage of Dr. prusiner'sprizewinning experience Virtual) http//www.cnn.com/WORLD/9710/06/nobel. http://www.twurled-world.com/MadCow/URL_Details/URL_166.htm

14. TwURL Details The Prion Diseases stanley B. prusiner Winner of the 1997 nobel Prize in Medicine DETAILS Scientific America article, ThePrionDiseases ; http://www.twurled-world.com/MadCow/URL_Details/URL_120.htm

15. Prusiner, Stanley in full stanley BEN prusiner (b. May 28 neurologist whose discovery of the diseasecausingprotein called prion in 1982 won him the 1997 nobel Prize for http://www.britannica.com/nobel/micro/736_0.html

Prusiner, Stanley B., in full STANLEY BEN PRUSINER (b. May 28, 1942, Des Moines, Iowa, U.S.), American neurologist whose discovery of the disease-causing protein called prion in 1982 won him the 1997 Nobel Prize for Physiology or Medicine. When first published, the prion theory met with much criticism but became widely accepted by the mid-1990s. In 1996, when a new variant of Creutzfeldt-Jakob disease emerged in the U.K., Prusiner's research was the focus of national attention. Fears abounded that the new variant of the disease might be linked to "mad cow" disease, a brain disorder that first appeared in British cattle a decade earlier. Some evidence suggested that the mad cow prion may have jumped species, infecting humans who consumed beef contaminated with the infectious agent. Because mad cow disease was believed to have been caused when the agent that causes scrapie in sheep was transmitted to cattle in feed, there was precedent for species-jumping events to occur. Prusiner's research also could have significant implications for such disorders as Alzheimer's disease and Parkinson's disease, which seemed to share certain characteristics with the diseases caused by prions.

16. 1997 Nobel Laureates 9. physiology or medicine, prusiner, stanley B. United States, discoveryof diseasecausing agents called prions, Monday, October 6. http://www.britannica.com/nobel/win_1997.html

Category 1997 Winner Country Prize-Winning Achievement Announcement chemistry Boyer, Paul D. United States explanation of the enzymatic conversion of adenosine triphosphate Wednesday, October 15 chemistry Skou, Jens C. Denmark discovery of sodium-potassium- activated adenosine triphosphatase Wednesday, October 15 chemistry Walker, John E. United Kingdom explanation of the enzymatic conversion of adenosine triphosphate Wednesday, October 15 physics Chu, Steven see Britannica's Nobelists United States process of trapping atoms with laser cooling Wednesday, October 15 physics Cohen-Tannoudji, Claude France process of trapping atoms with laser cooling Wednesday, October 15 physics Phillips, William D. United States process of trapping atoms with laser cooling Wednesday, October 15 economics Merton, Robert C. United States method for determining the value of stock options and other derivatives Tuesday, October 14 economics Scholes, Myron S. United States method for determining the value of stock options and other derivatives Tuesday

17. Premio Nobel De Medicina Para Stanley B. Prusiner Translate this page 11. Premio nobel de Medicina para stanley B. prusiner. ESPECIAL. Investigadornorteamericano descubre los priones, un nuevo principio http://www.geocities.com/lazosalzheimer/lazos-1997/lazos-11-04.html

LAZOS EDICION INTERNET Asociación Alzheimer de Monterrey, A.C. MONTERREY, MEXICO Boletín Informativo Septiembre - Octubre, 1997 / Año 2, No. 11 Premio Nobel de Medicina para Stanley B. Prusiner ESPECIAL Investigador norteamericano descubre los priones, un nuevo principio biológico de infección que puede ocasionar severas enfermedades en el cerebro como el Alzheimer Por haber descubierto los priones, un nuevo principio biológico de infección que puede ocasionar severas enfermedades en el cerebro, el estadounidense de 55 años, Stanley B. Prusiner, del Departamento de Neurología de la Universidad de California, de Estados Unidos, fue laureado el pasado día 6 de octubre con el Premio Nobel 1997 en Fisiología o Medicina. El anuncio oficial fue hecho por el Comité Nobel del Instituto Karolinska, organismo designado por Alfred Nobel en su testamento para entregar este premio. Los descubrimientos de Prusiner, hacen de su hallazgo uno de los más importantes en el campo de la Medicina y la Fisiología. Los priones son una nueva substancia infecciosa que puede ocasionar severas enfermedades en el cerebro del tipo locura, tanto en los seres humanos como en los animales. Los priones en principio inofensivos son proteínas producidas por el cuerpo humano, las cuales pueden cambiar de forma y producir enfermedades. El descubrimiento tiene un significado relevante para los estudios de las enfermedades mentales y la elaboración de medicamentos.

18. Noticias: Stanley B. Prusiner, Premio Nobel De Medicina 1997 Translate this page Guardar en 'Mis documentos'. stanley B. prusiner, Premio nobel de Medicina1997. stanley B. prusiner, Premio nobel de Medicina 1997 http://db.doyma.es/cgi-bin/wdbcgi.exe/doyma/press.plantilla?ident=1575

19. Noticias: Stanley B. Prusiner, Premio Nobel De Medicina 1997 Translate this page stanley B. prusiner, Premio nobel de Medicina 1997 Profesor de neurología y bioquímicade la Universidad de California, fue quien añadió los priones a la http://db.doyma.es/cgi-bin/wdbcgi.exe/doyma/press.plantilla_imprimir?ident=1575

20. CNN - American Wins Nobel Prize For Medicine - Oct 6, 1997 CNN.comCategory News Online Archives CNN.com 1997 October World...... of the foundation, the nobel Center in Stockholm and the selection of the laureatesPhysiology or Medicine 1997 awarded to stanley B. prusiner for his http://www.cnn.com/WORLD/9710/06/nobel/

American scientist wins Nobel Prize for medicine His work provides insight into brain diseases October 6, 1997 Web posted at: 8:51 a.m. EDT (1251 GMT) STOCKHOLM, Sweden (CNN) An American biologist won the 1997 Nobel prize for medicine Monday for his discovery of a new class of germ believed responsible for brain-wasting conditions such as "mad cow" disease. Stanley B. Prusiner, a professor at the University of California at San Francisco, discovered prions, "an entirely new genre of disease-causing agents," the Nobel citation from Sweden's Karolinska Institute said. "Prusiner has added prions to the list of well-known infectious agents, including bacteria, viruses, fungi and parasites." Prusiner began his search for prions in 1972, after one of his patients died from dementia resulting from Creutzfeldt-Jakob disease, the human equivalent of "mad cow" disease. After 10 years, he and his team produced a preparation derived from diseased hamsters' brains that contained a single agent he called a prion. His work was greeted with skepticism at first: Unlike known infectious agents, prions contain no genetic material, and are simply proteins. Furthermore, the gene encoding for prions is found in all mammals, including humans.

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