1. Michael Smith - Autobiography love, working at the bench and having more time for sailing and forskiing. From Les Prix nobel 1993. michael smith died in 2000. http://www.nobel.se/chemistry/laureates/1993/smith-autobio.html

The seven years from 1943 to 1950 were also a time when I became a boy scout. That was a piece of luck. The headmaster at Arnold School, Mr. Holdgate, at the end of my first term, sent me to a dentist, Mr. Paterson, in the hope that he could correct my protruding front teeth, about which I had been teased by my schoolmates. Mr. Paterson did not correct the problem with my teeth but he did introduce me to a wonderful scoutmaster, Mr. Barnes, who inducted me into the happy world of camping and outdoorsmanship which provided me with enjoyment and vacations throughout my secondary school years and right up to the present. An enjoyment that explains why I have a particular delight in living amid the rugged outdoors and beauty of British Columbia. The last year of our graduate studies saw me and my classmates writing to various American professors seeking post-doctoral fellowships. I had no luck in obtaining my desire of a fellowship on the west coast of the United States, but I heard, in the summer of 1956, that a young scientist in Vancouver, Canada, Gobind Khorana , might have a fellowship to work on the synthesis of biologically important organo-phosphates. While I knew this kind of chemistry was much more difficult than the cyclohexane stereochemistry in which I was trained, I wrote to him and was awarded a fellowship after an interview in London with the Director of the British Columbia Research Council, Dr. G.M. Shrum.

2. Chemistry 1993 The nobel Prize in Chemistry 1993. for contributions to the developmentsof methods within DNAbased chemistry . Kary B. Mullis, michael smith. http://www.nobel.se/chemistry/laureates/1993/

The Nobel Prize in Chemistry 1993 "for contributions to the developments of methods within DNA-based chemistry" "for his invention of the polymerase chain reaction (PCR) method" "for his fundamental contributions to the establishment of oligonucleotide-based, site-directed mutagenesis and its development for protein studies" Kary B. Mullis Michael Smith 1/2 of the prize 1/2 of the prize USA Canada La Jolla, CA, USA University of British Columbia Vancouver, Canada b. 1944 b. 1932 (in Blackpool, United Kingdom) d. 2000 The Nobel Prize in Chemistry 1993 Press Release Presentation Speech Illustrated Presentation ... Other Resources The 1993 Prize in: Physics Chemistry Physiology or Medicine Literature ... Economic Sciences Find a Laureate: Last modified November 1, 2000 The Official Web Site of The Nobel Foundation

3. Michael Smith Winner Of The 1993 Nobel Prize In Chemistry michael smith, a nobel Prize Laureate in Chemistry, at the nobel PrizeInternet Archive. michael smith. 1993 nobel Laureate in Chemistry http://almaz.com/nobel/chemistry/1993b.html

4. Dalai Lama Winner Of The 1989 Nobel Prize In Peace Links added by nobel Internet Archive visitors add your own link Information aboutthe Dalai Lama, from the Museum of Tolerance (submitted by michael smith); http://almaz.com/nobel/peace/1989a.html

5. Nobel Laureate And UBC Professor Michael Smith Lost To Cancer At 68 - UBC Public Thursday, October 5, 2000. nobel laureate and UBC professor michael smith lostto cancer at 68. nobel prizewinner and University of British Columbia Prof. http://www.publicaffairs.ubc.ca/media/releases/2000/mr-00-68.html

UBC Public Affairs News UBC Reports Media Releases ... Search Site Nobel laureate and UBC professor Michael Smith lost to cancer at 68 Nobel prizewinner and University of British Columbia Prof. Emeritus Michael Smith died yesterday of cancer. He was 68 years old. "We at UBC feel a real sense of personal loss," says Barry McBride, vice-president, Academic and Provost. "We've lost a colleague, a creative and distinguished scientist and a friend a warm and humble man known for his humanity and generosity. He was a great Canadian and I will miss his friendship, his unwavering commitment to excellence and his personal support." Smith, who won the Nobel Prize for Chemistry in 1993, was the director of BC Cancer Agency's Genome Sequence Centre in Vancouver. The prize recognized his groundbreaking work in reprogramming segments of DNA, the building blocks of life. "Michael's work launched a new era in genetics researchthat's his legacy to science," says Indira Samarasekera, UBC's vice-president, Research. "His discovery has paved the way to finding new treatments for life-threatening illness."

6. Michael Smith Awards - About Michael Smith michael smith (19322000) nobel laureate in Chemistry. Overnight, thenobel announcement made michael smith a Canadian science legend. http://www.nserc.ca/msmith/about_e.htm

Michael Smith (1932-2000) Nobel laureate in Chemistry Overnight, the Nobel announcement made Michael Smith a Canadian science legend. But while fame is a reality for all Nobel winners, Michael Smith put his own unique stamp on the experience. The scientist began using both his Nobel Prize money and his newfound clout to try to make a difference for others. Until his death, his determination to help more people understand science captured the imagination and respect of people all across Canada. Wherever he went, Michael Smith was a scientist who touched people deeply. Generosity in action Just your average everyday super scientist In addition to the Nobel Prize, Dr. Smith held a long list of awards and distinctions in recognition of his research and administrative contributions to Canadian science. He was also a Companion of the Order of Canada and received 25 honorary doctorates. A committed contributor to the transfer of biotechnology from research labs to industry, Dr. Smith served as the Scientific Leader of the Protein Engineering Network of Centres of Excellence from 1990 to 1994. At the time of his death, Dr. Smith was University Killam Professor and Peter Wall Distinguished Professor of Biotechnology at the University of British Columbia. In addition, he was Director of a new Genome Sequence Centre at the British Columbia Cancer Research Centre in Vancouver. In this position he had the responsibility of establishing a world class high throughput DNA sequencing facility which will contribute to our understanding of cancer and of other important genetic problems.

7. Prix Michael-Smith - A Propos De Michael Smith Translate this page Dès l'annonce du prix nobel, michael smith devint une légende canadiennedans le domaine des sciences. Toutefois, même si la http://www.nserc.ca/msmith/about_f.htm

Michael Smith Michael Smith (1932-2000) Tout simplement le super chercheur moyen de tous les jours En haut

8. Smith, Michael smith, michael. (b. April 26, 1932, Blackpool, Eng.), Britishborn Canadian biochemistwho won (with Kary B. Mullis) the 1993 nobel Prize for Chemistry for his http://www.britannica.com/nobel/micro/552_61.html

Smith, Michael (b. April 26, 1932, Blackpool, Eng.), British-born Canadian biochemist who won (with Kary B. Mullis ) the 1993 Nobel Prize for Chemistry for his development of a technique called oligonucleotide-based site-directed mutagenesis, which enabled researchers to introduce specific mutations into genes and, thus, to the proteins that they encode. Smith received a Ph.D. from the University of Manchester, Eng., in 1956. He became a Canadian citizen in 1964. After holding a number of positions in Canada and the United States, he joined the faculty of the University of British Columbia in 1966, becoming director of the university's biotechnology laboratory in 1987. He was a founder of ZymoGenetics Inc., a biotechnology company.

9. Nobel Prize Winners For 1991-Present chemistry, smith, michael, Canada, inventors of techniques for gene study and manipulation,economics, Fogel, Robert William, US, contributions to economic history, http://www.britannica.com/nobel/1991_pres.html

Year Category Article Country* Achievement Literary Area chemistry Ernst, Richard R. Switzerland improvements in nuclear magnetic resonance spectroscopy economic science Coase, Ronald U.S. application of economic principles to the study of law literature Gordimer, Nadine South Africa novelist peace Aung San Suu Kyi Myanmar physics Gennes, Pierre-Gilles de France discovery of general rules for behaviour of molecules physiology/medicine Neher, Erwin Germany discovery of how cells communicate, as related to diseases physiology/medicine Sakmann, Bert Germany discovery of how cells communicate, as related to diseases chemistry Marcus, Rudolph A. U.S. explanation of how electrons transfer between molecules economics Becker, Gary S. U.S. application of economic theory to social sciences literature Walcott, Derek St. Lucia poet peace Guatemala physics Charpak, Georges France inventor of detector that traces subatomic particles physiology/medicine Fischer, Edmond H. U.S. discovery of class of enzymes called protein kinases physiology/medicine Krebs, Edwin Gerhard

10. Science.ca Profile : Michael Smith michael smith. Achievement Biochemist, Molecular Biologist nobel Prize in Chemistry1993 for discovering sitedirected mutagenesis—how to make a genetic http://www.science.ca/scientists/scientistprofile.php?pID=18

11. Science.ca Scientists nobel Chemistry 1992 for Electron Transfer Reactions (eg Rust) John Polanyi, nobelChemistry 1986 for Chemi luminescence michael smith, nobel Chemistry 1993 http://www.science.ca/scientists/scientists.php

Now listing the profiles for 214 Canadian scientists in 36 areas of expertise. 174 (81%) are men while 40 (19%) are women. Search our database of scientists by... Category All Engineering Math/Compt. Physics Chemistry Earth Sci. Biology Health Other Region All Central East Ontario Other Quebec West Gender All Male Female Endel Tulving Psychology Sid Altman Molecular Biology Biruté Galdikas Zoology I’ve always wanted to study the one primate who never left the Garden of Eden. I want to know what we left behind. Ten Canadian scientists have won the Nobel Prize Sid Altman Nobel Chemistry 1989 for Catalytic RNA Sir Frederick Banting Nobel Medicine 1923 for Discovering Insulin Bert Brockhouse Nobel Physics 1994 for Condensed Matter Gerhard Herzberg Nobel Chemistry 1971 for Molecular Spectroscopy David Hubel Nobel Medicine 1981 for Mapping the Visual Cortext Rudolph Marcus Nobel Chemistry 1992 for Electron Transfer Reactions (e.g.: Rust) John Polanyi Nobel Chemistry 1986 for Chemi- luminescence Michael Smith Nobel Chemistry 1993 for Site-Based Mutagenesis Henry Taube Nobel Chemistry 1983 for Electron Transfer Reactions Richard Taylor Nobel Physics 1990 for verifying the Quark Theory Links to other science biography sites: Canadian Aviation Hall of Fame Cenius Math site by Alan Cain Women In Technology Industries Well known Canadians ... Altman, Sid

12. Michael Smith- Nobel Prize In Chemistry Accomplishment michael smith won a nobel Prize for organic chemistry(a total of half a million dollars) for work on the genetic code. http://www.occdsb.on.ca/~sel/cahero/michael_smith.htm

Science: Michael Smith If You Have It, Share It! By Marc P.(11) Gr. 6 St. Martin de Porres, Ottawa, Ontario Field: Chemistry Date of birth: , he is still alive Accomplishment: Michael Smith won a Nobel Prize for organic chemistry (a total of half a million dollars) for work on the genetic code. He discovered a new way to create genetic mutation in living things. This has allowed many researchers around the world to have special bacteria, plants, and animals with new qualities or abilities which do not occur naturally or would avoid years of crossbreeding. He didn't keep the money though. He gave half of it to researchers working on the genetics of schizophrenia, a widespread mental disorder for which research money is scarce. The other half he gave to Science World BC and to the Society for Canadian Women in Science and Technology. Why I admire him: Although he could have kept his money, he gave it away instead. By doing this he is thinking more about others more than himself.

13. Adventures In Science And Technology - Michael Smith, Biochemist Even after winning his nobel Prize, however, michael smith is still doingresearch in biochemistry. Right now he is working on genomics. http://collections.ic.gc.ca/science/english/chem/smith.html

Born in Blackpool, England on April 26, 1932, Michael Smith struggled through hard times when he was a young child to become the successful scientist he is today. When he was seven years old, the Second World War began, causing great hardships in England. At eleven years of age, he received a scholarship that allowed him to continue his education up to the university level. He found school difficult, and many of his happiest times during his school years were spent with the Boy Scouts, an organization he is still involved with today. He attended Manchester University in Manchester, England where he took both an honours degree and his Ph.D. in Chemistry. After finishing those degrees, he wanted to go to North America to study more. He moved to Vancouver B.C. where he found his mentor Har Gobind Khorana. Gobind Khorana was a molecular biologist studying molecules that are important to research into genetics . It was in Gobind Khorana's lab that Michael Smith began learning the chemistry that would form the basis of his future research. Michael Smith was especially happy in Vancouver because of the natural, unspoiled beauty of the land in British Columbia. After completing his education, Michael Smith worked at the Fisheries Research Board of Canada Laboratory. Though the work he was doing there was not related to genetics, Michael Smith continued his research into that subject on the side. In 1966 he became a professor of biochemistry at the University of British Columbia. Undoubtedly, his greatest accomplishment in the field of chemistry came in 1993 when he was awarded the Nobel Prize in Chemistry for discovering a process called site-directed mutagenesis. This is very important for molecular biology; it is a process for making a

14. Aventures En Science Et Technologie - Michael Smith, Biochimiste Translate this page Même après avoir gagné le prix nobel, michael smith continue sa rechercheen biochimie. Maintenant, il explore le génie protéique http://collections.ic.gc.ca/science/francais/chem/smith.html

Science World Prix Michael Smith pour la promotion de sciences Tu peux en apprendre plus sur Michael Smith ici La physique La chimie La biologie ... L'informatique Produit par Galactics Commentaires: galactics@spacesim.org

15. Conférence Du Nobel Michael Smith Translate this page Septembre Conférence du nobel michael smith. Cité universitaire,Québec, le 12 septembre 1994. Le récipiendaire du prix nobel http://www.ulaval.ca/scom/Communiques.de.presse/1994/08/016.html

Septembre Conférence du Nobel Michael Smith Cité universitaire, Québec, le 12 septembre 1994. Le récipiendaire du prix Nobel de médecine 1993, Michael Smith, sera de passage dans la région de Québec du 14 au 16 septembre, à l'invitation de Fernand Labrie, directeur de la recherche et responsable du Laboratoire d'endocrinologie moléculaire du CHUL. En plus de rencontrer les chercheurs de laboratoires affiliés à l'Université Laval, il prononcera une conférence publique intitulée «L'ADN de synthèse en biologie», le vendredi 16 septembre à 9h30, à l'amphithéâtre du Centre hospitalier de l'Université Laval. Le professeur Smith est originaire d'Angleterre mais il a mené la plus grande partie de sa carrière au Canada. Il est aujourd'hui directeur du Laboratoire de biotechnologie et professeur au Département de biochimie et de biologie moléculaire de l'Université de la Colombie britannique. Pour information: Jean Hamann Conseiller en communication scientifique

16. Michael Smith Superstar Translate this page la science au Canada. Salle comble pour michael smith, prix nobel dechimie 1993 et Canadien extraordinaire. Si comble qu'il aurait http://www.ulaval.ca/scom/Au.fil.des.evenements/1994/17/015.html

22 septembre 1994 Michael Smith, superstar On sent, pendant les conférences du prix Nobel de chimie 1993, une ferveur qui rappelle celle de certiains concerts rock... Vendredi 16 septembre, ils étaient 300, pressés les uns contre les autres, dans un amphithéâtre contenant au mieux 200 places, certains assis dans les marches, d'autres par terre près du podium, excités et impatients à l'idée de voir et d'entendre le Wayne Gretzky de la science au Canada. Salle comble pour Michael Smith, prix Nobel de chimie 1993 et Canadien extraordinaire. Si comble qu'il aurait été impossible de sortir de l'amphithéâtre du CHUL sans piétiner quelques corps. Il régnait, dans cette salle surchauffée, une atmosphère de concert rock et on aurait cru quiconque aurait raconté qu'il avait dormi sur place la nuit précédente pour avoir un bon siège. Un parcours original Suspendus à ses lèvres, chercheurs accomplis et jeunes étudiants- chercheurs l'ont écouté raconter comment l'histoire de l'ADN et sa propre histoire se sont croisées. Originaire d'Angleterre et chimiste de formation, Michael Smith arrive au Canada en 1956 pour un stage post- doctorat au terme duquel il doit retourner au pays où un emploi dans l'industrie l'attend. Différents événements amènent le jeune chercheur à revoir ses projets. Il reste en Amérique et met ses talents de chimiste au service de la recherche en biologie, plus particulièrement de la recherche sur l'ADN dont on vient d'élucider la structure. La pièce maîtresse de l'ensemble de son oeuvre de chercheur est l'utilisation de petites séquences synthétiques d'ADN comme outils de recherche en biologie moléculaire. La technique qu'il a mise au point permet de détecter des gènes, d'en identifier les composantes et d'introduire de façon prédéterminée des mutations dans l'ADN afin d'étudier la fonction des gènes et des protéines. «J'aimerais être un jeune chercheur à nouveau parce qu'il existe maintenant tellement d'outils intéressants pour tester rapidement des hypothèses. Malheureusement, ces outils arrivent à un moment où l'économie traverse une période difficile. Les fonds de recherche sont difficiles à obtenir et les politiciens font des pressions en faveur de recherches plus appliquées.»

17. Nobel Laureate Molecular Biologist Michael Smith Community Centre. nobel Prize winner michael smith receives Royal Bank Award. nobellaureate michael smith of Vancouver with the Royal Bank Award gold medal. http://www.rbc.com/community/donations/award/recipient.html

About Us Investor Relations Media NewsRoom Economics ... Compliments / Complaints Community Centre Nobel Prize winner Michael Smith receives Royal Bank Award Royal Bank Award recipient Michael Smith and Royal Bank chairman and CEO John Cleghorn with a $ 125,000 cheque that will launch a campaign to develop a state-of-the art facility to house the B.C. Cancer Research Centre. Royal Bank chairman and CEO John Cleghorn put Michael Smith's career under a microscope during a weekend awards presentation ceremony, describing the Nobel Prize winning laureate as "part wizard, part pragmatist, part scientist and part dreamer." "Our Royal Bank Award recipient has described himself as 'just a chemist'," Cleghorn told 200 friends and supporters of the pioneering biochemist and molecular biologist at a ceremony in the Great Hall of the Museum of Anthropology, at the University of British Columbia. "It's apparent to me that Michael Smith is much more than just a chemist. "He's a molecular biologist, which means he's one part wizard and one part pragmatist," added Cleghorn. "He's a geneticist, which means he's one part scientist and one part dreamer.

18. Michael Smith Science Challenge Translate this page michael smith Presented by UBC Faculty of Science and NSERC PromoScience Nomméen l'honneur de Dr. michael smith, récipiendaire du Prix nobel Présenté par http://www.smithchallenge.ubc.ca/

Michael Smith Science Challenge 2003 Défi Scientifique Michael Smith 2003 This exam is to be written on Friday, April 11, 2003, and it is open to students in Grade 10 or lower. L'examen se déroulera le Vendredi 11 avril 2003 et est destiné aux étudiants de Secondaire 4 ou moins. Click here to access Michael Smith Challenge 2003: Exam Booklet and Answer Sheet! This is a restricted area and is password protected! Please note that: username = your email address If you have problems with accessing the exam, please send an email to antonysc@physics.ubc.ca. Cliquer ici pour accéder: au cahier d'examen et à la feuille de réponses du Défi Michael Smith 2003! L'accès à cette zone est limité et protégé par un mot de passe! Veuillez noter: Nom d'usager = votre courrier électronique Si vous éprouvez des difficultés pour accéder à l'examen, envoyez un courrier électronique à antonysc@physics.ubc.ca. Named in Honour of: UBC's Nobel Prize Winner Dr. Michael Smith

19. Michael Smith Science Challenge Translate this page Nommé en l'honneur de Dr. michael smith, récipiendaire du Prix nobel Présentépar La Faculté des Sciences de UBC et Promoscience CRSNG Organisé par Le http://www.physics.ubc.ca/~outreach/smith/

Michael Smith Science Challenge 2003 Défi Scientifique Michael Smith 2003 This exam is to be written on Friday, April 11, 2003, and it is open to students in Grade 10 or lower. L'examen se déroulera le Vendredi 11 avril 2003 et est destiné aux étudiants de Secondaire 4 ou moins. Click here to access Michael Smith Challenge 2003: Exam Booklet and Answer Sheet! This is a restricted area and is password protected! Please note that: username = your email address If you have problems with accessing the exam, please send an email to antonysc@physics.ubc.ca. Cliquer ici pour accéder: au cahier d'examen et à la feuille de réponses du Défi Michael Smith 2003! L'accès à cette zone est limité et protégé par un mot de passe! Veuillez noter: Nom d'usager = votre courrier électronique Si vous éprouvez des difficultés pour accéder à l'examen, envoyez un courrier électronique à antonysc@physics.ubc.ca. Named in Honour of: UBC's Nobel Prize Winner Dr. Michael Smith

20. UBC Archives - Michael Smith - Description Former University of British Columbia faculty member and nobel prize winner MichaelSmith (1932–2000) was born in Blackpool, England where he attended Arnold http://www.library.ubc.ca/archives/u_arch/smithm.html

Michael Smith fonds Compiled by Christopher Hives (2001) Table of Contents Fonds Description Title / Dates of Creation / Physical Description Biographical Sketch Scope and Content ... File List Fonds Description Michael Smith fonds. 4.4 m of textual records. 1,576 slides. 9 photographs. In 1993, Smith was awarded the Nobel Prize in Chemistry for his pioneering work in the development of the technology of "site directed mutagenesis", a technique which allows gene sequences to be altered in a designated manner. In commenting on the importance of this development, a departmental tribute to Smith observed that: Site directed mutagenesis allows the reprogramming of genes to investigate the influence of genetic makeup on the characteristics and development of cells. Proteins of medical or industrial importance, such as antibodies and enzymes, can be redesigned to improve their stability and effectiveness. Dr. Smith’s contribution to many fields of biology and medicine is therefore enormous. The fonds consists of Smith’s biographical information, speeches, correspondence, laboratory notes and research material, copies of publications, and slides and presentation materials. Top Series Descriptions Biographical Series.

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