21. GEDRI Project Inventory: Detection And Fate Of Endocrine Disruptors In The Envir GEDRI Project Detection and fate of endocrine disruptors in the environment. 2.Project Title Detection and fate of endocrine disruptors in the environment. http://endocrine.ei.jrc.it/gedri/pack_edri.FullScreen?p_rs_id=83

22. Redirect The page you have requested on endocrine disruptors has moved. Your browserwill be redirected to the new location in a couple seconds. http://www.mindfully.org/Pesticide/What-Are-EDs-PWG.htm

The page you have requested on endocrine disruptors has moved. Your browser will be redirected to the new location in a couple seconds. If it does not happen, please click on this link If you have come to this page from an outside location click here to get back to mindfully.org

23. Pesticides, Toxins, Endocrine Disruptors Pre2002 Mindfully.org Pesticides, Toxins, endocrine disruptors pre2002. The Lowdown on LowDoseendocrine disruptors - Environmental Health Perspectives Sep01. http://www.mindfully.org/Pesticide/pesticide.htm

Pesticides, Toxins, Endocrine Disruptors Pesticides What is a Pesticide? - U.S. EPA Office of Pesticide Programs Lawncare Industry Advertising : Don't be fooled by it. - Paul Goettlich 15sep01 A Small Sampling of Lawsuits Against Terminix aka Terminex - one of many companies Roundup Not as Safe as Table Salt Not a Safer Pesticide Genetically Engineered Crops Mean Less Pesticide Use? Charles Benbrook / Pesticide Outlook Oct01 Pesticide Residues on Fruits and Vegetables Heavily Consumed by Young Children - Landrigan, et al EHP Do Pesticides Cause Lymphoma ? - Lymphoma Foundation of America (3-star *** at LFA Website) Studies of Pesticides and Lymphoma What are Endocrine Disruptors? - Paul Goettlich 12nov99 Lake Apopka Muck farms caused lupus - Sentinel 28dec01 Clopyralid by Dow AgroSciences Found in Composted Grass in Several States - LA Times 27dec01 Canada's Regulatory Proposal PRO2001-02 , A proposal to make Canada's pesticide regulation modeled after the US (NAFTA) - Comments by Paul Goettlich 9dec01 Endocrine disrupters and human health - Editorial/British Medical Journal 323:1317-1318 8dec01 U.S. Will Use Once-Banned Human Tests Pesticides: EPA says it will accept industry data

24. Endocrine Disruptors Bad News for Boys Linking Hypospadias and endocrine disruptors Wakefield, Julie. NIEHSand CDC Track Human Exposures to endocrine disruptors Manuel, John. http://ehis.niehs.nih.gov/topic/endodisrupt.html

Publications Services Environews by Topic Index ... Search Environews by Topic: Endocrine Disruptors Pollutants Alter Play: Another Way PCBs Affect Children. Potera, Carol. (110N10 SS: A590-A591) Pulp Mills Make More Males: Skewing the Sex Ratio in Fish. Freeman, Kris S. (110N8 SS: A474) Bad News for Boys: Linking Hypospadias and Endocrine Disruptors Wakefield, Julie. (109N11 SS: A542-A543) The Lowdown on Low-Dose Endocrine Disruptors Schmidt, Charles W. (109N9 NIEHS: A418-A419) Mice Beat Rats: The Best Model for Testing Endocrine Disruptors Manuel, John S. (109N8 SS: A387) Arsenic and Endocrines: New Study Suggests Disruption Josephson, Julian. (109N3 SS: A132-A133) Drugged Drinking Water Potera, Carol. (108N10 FOR: A446) Chemical Cocktails: Are Mixed Pesticides More Potent? Holzman, David C. (108N3 FOR: A114) NRC: Not Enough Data (108N1 FOR: A16) Estrogen's a Natural in Herbal Remedies (107N9 FOR: A447) Under the ScopeAn Environment for Development Fisher, Brandy E. (107N6 NIEHS: A298-A300) Herbal Medicine Is Potent Estrogen (107N3 FOR: A137-A138) NIEHS and CDC Track Human Exposures to Endocrine Disruptors Manuel, John. (107N1 NIEHS:A16)

25. OSH Answers: Endocrine Disruptors endocrine disruptors. a detectable effect. Back To Top. What kinds ofsubstances can be an endocrine disruptors? The number of substances http://www.ccohs.ca/oshanswers/chemicals/endocrine.html

Canadian Centre for Occupational Health and Safety Centre canadien d'hygiène et de sécurité au travail Français Contact Us Help Canada Site ... Shop@CCOHS Endocrine Disruptors What is the endocrine system? What are some examples of hormones? Why should we be concerned about the endocrine system? How can the normal communication of the endocrine system be disrupted? ... Where are endocrine disruptors often found and what are examples? OSH Answers Feedback Printer Friendly Layout Inquiries Service The Inquiries Service at CCOHS answers questions on the health or safety concerns people have about the work they do. More on Inquiries Service Printer Friendly Layout Endocrine Disruptors What is the endocrine system? The endocrine system is comprised of a number of glands in the body that do not have ducts and other similar structures. Glands in the endocrine system include the ovaries; the testes; the thyroid, parathyroid, adrenal, and pituitary glands; the pineal body; the pancreas; as well as cells of the gastrointestinal tract, and the placenta. What distinguishes endocrine glands from other glands is that endocrine glands secrete certain chemical called hormones and other glands produce other chemicals or fluids; for example, lacrimal glands secrete tears, salivary glands produce saliva, and sweat glands produce sweat. Hormones (so-called "chemical messengers") produced by endocrine glands enter the capillaries (and lymph vessels) of the blood circulatory system. They travel through the bloodstream to specific "receptors" in target organs or systems where they can trigger their biological effects.

26. CCOHS: Features: Assessing The Risk And Extent Of Endocrine Disruptors Assessing the Risk and Extent of endocrine disruptors. Synthetic chemicals suspectedas endocrine disruptors may reach humans and animals in a variety of ways. http://www.ccohs.ca/headlines/text69.html

Canadian Centre for Occupational Health and Safety Centre canadien d'hygiène et de sécurité au travail Français Contact Us Help Canada Site ... Shop@CCOHS Features Features Archive Assessing the Risk and Extent of Endocrine Disruptors The human body is immensely complex, and our knowledge and awareness of its complexity continues to grow. One of the most disquieting discoveries in recent years concerns the possible roles of environmental chemicals on endocrine systems. Endocrine systems are present not only in humans but in "higher" animals such as birds, fish, and mammals. Endocrine systems coordinate and regulate many important body functions such as growth and maturation, behaviour, reproduction and embryo development. They do this by making and releasing hormones which act as "chemical messengers." Certain tissues in the body have very specific receptors for the hormones. By interacting with these receptors, the hormones trigger responses. Among the hormones ("chemical messengers") operating within the endocrine system are estrogen (a female sex hormone produced by the ovaries); thyroid hormone (influencing the function of virtually every cell in the body); and ACTH (produced by the pituitary gland to influence the release of adrenalin from the adrenal gland).

27. Endocrine Disruptors The State Of Science endocrine disruptors. endocrine disruptors The State of the Science TedSchettler MD, MPH Greater Boston Physicians for Social Responsibility http://www.psr.org/tedfs.htm

28. PSR Endocrine Disruptors Endocrine Distruptor Information. Questions and Answers about EndocrineDisruptors Generations at Risk Two reports about how Environmental http://www.psr.org/edpage.htm

29. Detecting Endocrine Disruptors Science Link. Detecting endocrine disruptors. by Mark Lowey. Researchers in theUnited Kingdom first raised the alarm about endocrine disruptors 12 years ago. http://www.interlog.com/~cswa/slink/apr01/lowey.html

Detecting Endocrine Disruptors by Mark Lowey Researchers in the United Kingdom first raised the alarm about endocrine disruptors 12 years ago. They discovered genetically male fish that had developed ovaries and whose bodies contained a protein that produces eggs in female fish. Since then, "there's increasing evidence that humans and wildlife species have suffered adversely from exposure to environmental endocrine disruptors," Habibi says. One group of chemicals, called phthalates, is widely used in consumer products. Diisononyl phthlate (DINP), a plasticizer, is added to plastics to make them soft and pliable. DINP and other phthalates are used in products that include children's soothers and soft squeeze toys, shower curtains, medical devices such as tubing and intravenous bags, upholstery, raincoats and balls. Studies in laboratory animals show another phthalate, dibutyl phthalate (DBP), can cause testicular atrophy, absent testes and reduced sperm count. An initial investigation by the Environmental Working Group in the US suggests that DBP is found in about one-third of the nail polishes on the market and a variety of other cosmetic products. The full report and a list of products are available at www.ewg.org/pub/home/reports/beautysecrets/pr.html

30. EMS - Endocrine Disruptors Facts endocrine disruptors. Expert endocrine disruptors can cause health problemsat doses far below the threshold for acute toxicity. Numerous http://www.ems.org/endocrine_disruptors/facts.html

31. EDKB What Are Endocrine Disruptors What are endocrine disruptors? Endocrine mechanisms. A comprehensive definitionof endocrine disruptors, given in Kavlock, 1996 40 follows http://edkb.fda.gov/endodisrupt.html

Health and Human Services Food and Drug Administration NCTR EDKB Home ... Publications What are Endocrine Disruptors? Endocrine disrupting compounds (EDC's) are chemicals that either mimic endogenous hormones, interfere with pharmacokinetics or act by other mechanisms. A comprehensive definition of endocrine disruptors, given in [ Kavlock, 1996 #40 ] follows: "An exogenous agent that interferes with the production, release, transport, metabolism, binding, action or elimination of natural hormones in the body responsible for the maintenance of homeostasis and the regulation of developmental processes." This definition includes the general types of mechanisms for endocrine disruptors. Such adverse effects as compromised reproductive fitness, functional or morphological birth defects, cancer and altered immune functions, among others, have been reported in the scientific press for wildlife, in vitro, and in vivo studies. These findings have received considerable attention in the popular press, led to government regulatory actions and expanded research in Europe, Asia and the U.S. Many suspected endocrine disruptors (ED's) are high-volume, economically important chemicals, a factor that magnifies the need for resolution of the scientific issues [ Kavlock, 1996 #40

32. Pesticides, Endocrine Disruptors, And Other Toxic Substances - National Center F Health Studies Branch. Pesticides, endocrine disruptors, and OtherToxic Substances. CDC is collaborating with the Texas Department http://www.cdc.gov/nceh/hsb/toxins.htm

Environmental Health Studies Content Home Churchill County (Fallon), Nevada Cancer Study Confined Animal Feeding Operations (CAFO's) Drinking Water and Water-Related Issues ... NCEH Brochures Health Studies Branch Pesticides, Endocrine Disruptors, and Other Toxic Substances CDC is collaborating with the Texas Department of Health and the United States Environmental Protection Agency (USEPA) on a pilot surveillance project to track acute, nonoccupational, pesticide-related health conditions. The purpose of this surveillance program is to evaluate the public health impact of nonoccupational pesticide exposures in Texas. It involves active case finding and follow-up activities, outbreak investigations, and intervention/prevention activities. A final component will evaluate the program for completeness and representativeness of the case-finding effort. CDC is assisting the New Mexico Department of Health to evaluate statewide 1998 poison control center reports of nonoccupational pesticide poisoning. CDC will then use a descriptive analysis of the data to identify intervention/ prevention activities that may help reduce nonoccupational pesticide poisoning in New Mexico.

33. Questions About Endocrine Disruptors Questions about endocrine disruptors. Here are some of the most frequentlyasked questions about the endocrine system and endocrine disruptors http://ace.orst.edu/info/extoxnet/faqs/pesticide/endocrine.htm

Questions about Endocrine Disruptors Here are some of the most frequently asked questions about the endocrine system and endocrine disruptors: What is the endocrine system? What are hormones? How do hormones work? How do scientists study hormones? ... Links to more information about Endocrine Disruptors What is the endocrine system? The endocrine system is composed of ductless glands that secret hormones into the blood stream to act at distant sites. Together with the nervous system, the endocrine system is responsible for the integration of many different processes which allow complicated organisms to function as a unit (maintain homeostasis). What does the endocrine system look like? What are hormones? Hormones can be proteins, polypeptides, amino acids, or steroids. The most well known hormones are the sex steroids estrogen, produced in the ovaries, and testosterone, produced in the testes. Estrogen and testosterone are also produced in the adrenal glands of both sexes. Other hormones include thyroxin, produced in the thyroid, and insulin, produced in the pancreas. The pituitary and hypothalamus in the brain release a variety of hormones that affect other organs, including the sex glands. How do hormones work?

34. NIH Guide: ENDOCRINE DISRUPTORS: EPIDEMIOLOGIC APPROACHES endocrine disruptors EPIDEMIOLOGIC APPROACHES Release Date June 12, 2000 RFA OH01-001National Institute for Occupational Safety and Health (NIOSH), Center http://grants.nih.gov/grants/guide/rfa-files/RFA-OH-01-001.html

http://www.health.gov/healthypeople http://grants.nih.gov/grants/guide/notice-files/not98-024.html axc2@cdc.gov APPLICATION PROCEDURES The research grant application form PHS 398 (rev. 4/98) is to be used for these grants. These forms are available at most institutional offices of sponsored research and from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/435-0714, email: GrantsInfo@nih.gov . The forms may also be downloaded from the Internet at: http://grants.nih.gov/grants/funding/phs398/phs398.html Specific application instructions for this RFA have been modified to reflect "MODULAR GRANT" and "JUST-IN-TIME" streamlining efforts being examined by the NIH. Complete and detailed instructions and information on Modular Grants can be found at http://grants.nih.gov/grants/funding/modular/modular.htm http://grants.nih.gov/grants/funding/modular/modular.htm http://grants.nih.gov/grants/funding/modular/modular.htm http://grants.nih.gov/grants/funding/phs398/label-bk.pdf ... http://www.cdc.gov/niosh/nora.html ". Direct inquiries regarding programmatic issues to: Michael J. Galvin, Ph.D. Research Grants Program National Institute for Occupational Safety and Health Centers for Disease Control and Prevention 1600 Clifton Road, N.E. Building 1, Room 3053, MS D-30 Atlanta, GA 30333 Telephone: (404) 639-3343 FAX: (404) 639-4616 Email: mtg3@cdc.gov

35. Endocrine Disruptors endocrine disruptors. IPCS HomePage / Activities/ Emerging Issues main / Human Data Initiative. http://www.who.int/pcs/emerg_site/edc/edc.html

ENDOCRINE DISRUPTORS IPCS HomePage Activities Emerging Issues main Human Data Initiative

36. Endocrine Disruptors - Description endocrine disruptors (EDCs) encompass a variety of chemicals, including naturaland synthetic hormones, natural plant constituents, pesticides, monomers and http://www.who.int/pcs/emerg_site/edc/edc_descr.html

Background There is a growing concern that a number of substances which interfere with the normal functions of the body governed by the endocrine system have the potential of causing adverse effects in both humans and wildlife. Endocrine disruptors (EDCs) encompass a variety of chemicals, including natural and synthetic hormones, natural plant constituents, pesticides, monomers and additives used in the plastics industry, detergent components and breakdown products, and persistent environmental pollutants. Some of the potential environmental EDCs are ubiquitous and persistent in the environment and cross national boundaries. Human health effects potentially linked to EDC exposure include: breast, prostate and testicular cancer; diminished semen quantity and quality; and impaired behavioural/mental, immune and thyroid function in developing children. Ecological effects potentially linked to EDC exposure include altered sex differentiation, malformations in reproductive organs, altered immune function and altered population levels. These effects have been observed in invertebrates, fish, amphibia, reptiles, birds and mammals. However, in both situations, information on specific exposures is generally lacking, mechanisms of action are poorly defined, and other factors (e.g. diet) may be present, making it difficult to demonstrate a direct link between exposure and effect. Concerns expressed by international and national authorities regarding the potential adverse human and ecological impacts of endocrine disruptors, resulted in the IPCS taking a leadership role on two projects to address these issues globally.

37. Endocrine Disruptors interfere with the endocrine system are persistent and undergo biomagnificationin the food web, which makes them of greater concern as endocrine disruptors. http://www.naturodoc.com/library/women/endocrine_disruptors.htm

Site Index Natural Health Articles Health News About Us ... The Value of Mothering NaturoDoc Note: Be sure to read this report, or at least the Consensus Statement, Section 4 . The importance of these issues and the credibility of these scientists puts a priority on this report for all of our lives. Statement from the Work Session on Environmental Endocrine-Disrupting Chemicals Neural, Endocrine and Behavioral Effects The Problem A multidisciplinary group of international experts gathered for a work session on "Environmental Endocrine-Disrupting Chemicals: Neural, Endocrine and Behavioral Effects" under the auspices of the International School of Ethology at the Ettore Majorana Centre for Scientific Culture in Erice, Sicily, November 5-10, 1995. The need for this work session grew out of evidence accumulated since the first consensus statement on endocrine disrupting chemicals was released in October, 1991. The first statement was framed as a product of a work session on "Chemically-Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection." Research since 1991 has reinforced concerns over the scope of the problems posed to human health and ecological systems by endocrine-disrupting chemicals. New evidence is especially worrisome because it underscores the exquisite sensitivity of the developing nervous system to chemical perturbations that result in functional abnormalities. Moreover, the consequences of these perturbations depend upon the stage of development during which exposure occurs and are expressed in different ways at different times in life, from birth through to advanced age.

38. EUROPA - Environment - Implementation Of The Community Strategy For Endocrine Di European Workshop on endocrine disruptors. The results of this workshop arenow available for downloading (pdf format) Final Workshop Report (270K); http://europa.eu.int/comm/environment/docum/01262_en.htm

en EUROPA European Commission Environment Resources ... Developments COMMUNICATION FROM THE COMMISSION TO THE COUNCIL AND THE EUROPEAN PARLIAMENT on the implementation of the Community Strategy for Endocrine Disrupters - a range of substances suspected of interfering with the hormone systems of humans and wildlife COM (2001)262 Following the adoption by the Commission of a Communication to Council and European Parliament on a Community Strategy for Endocrine Disrupters in December 1999 ( COM(1999)706 ), the Council invited the Commission to report regularly on the progress of work, and for the first time in early 2001. A key short-term action of the Community Strategy is the establishment of a priority list of substances for further evaluation of their role in endocrine disruption. During 2000, a candidate list of 553 man-made substances and 9 synthetic/natural hormones has been identified. The candidate list has been divided into three separate groupings of substances depending on the level of information available, and a priority list of actions has been developed in order to further evaluate the role of these substances in endocrine disruption. Actions, timeframes and groupings of substances are presented in Annex 1 of this Communication. Regarding other short-term actions, the Commission held

39. Endocrine Disruptors endocrine disruptors. All of the following examples represent animal populationsthat had extreme exposure to known endocrine disruptors http://www.ccaej.org/projects/endocrine.htm

Endocrine Disruptors Our Stolen Future: Are We Threatening Our Fertility, Intelligence ad Survival? by Theo Colborn, Diane Dumanoski and John Peterson Myers. The Endocrine System The endocrine system acts as the chemical messenger system for communication throughout our body. The main purpose of the endocrine system is to control and regulate body functions especially growth and development. This is accomplished through hormones, potent, biologically-active chemical messengers that in very small amounts can produce significant biological effects. Hormones are released from the brain, thyroid, ovaries, testes and other endocrine glands and then carries them through the bloodstream to the target cells and organs where they activate and regulate various functions. The system is made up of the pituitary gland which acts as a control center telling the ovaries or the thyroid when to send their signals and how much hormone to send. The pituitary gets its cues from another gland, the hypothalamus, which acts as a thermostat telling the pituitary to increase production, slow down or shut off. These messages travel back and forth continuously to keep all parts of the organism operating as one coordinated being. Hormones also guide the growth of a baby’s nervous system and immune system and "programs" organs and tissues such as the liver, blood, kidneys and muscles so they will function properly. During early development this regulation of growth and development is critical for a child. The thyroid hormone, for example, is essential for normal neurological function and development. Deficiencies of thyroid hormones during fetal development or during early infancy can lead to mental retardation, hearing loss and speech problems. Children with thyroid deficiencies, even those with normal IQ’s, can have language comprehension problems, impaired learning and memory and hyperactive behavior.

40. Dioxin Analysis By Xenobiotic Detections Systems, Inc. XDS's endocrine disruptors Assays. endocrine disruptors. Endocrine disruptingchemicals affect normal hormone responses in both humans and wildlife. http://www.dioxins.com/pages/Endocrinepage.shtml

Xenobiotic Detection Systems, Inc About XDS Dioxin Toxicity Publications Glossary ... XDS's Endocrine Disruptors Assays Endocrine Disruptors Endocrine disrupting chemicals affect normal hormone responses in both humans and wildlife. Concern about these chemicals has increased worldwide as studies have suggested that these chemicals may be associated with global increases in testicular cancer, regional declines in sperm counts, altered sex ratios in wildlife populations, increases in the incidence of breast cancer and endometriosis, and accelerated puberty in females. Molecular mechanism of estrogen hormone action.

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