81. EESJ - Endocrine Disruptors Case Study. Case Studies in Earth Environmental Science Journalism. endocrine disruptors. WorldWildlife Fund, 1998. Known and Suspected endocrine disruptors. http://www.ldeo.columbia.edu/eesj/casestudies/EESJendocrine.html

Endocrine Disruptors. Jump down to Reading List Jump down to Endocrine Disruptors Questions to Ponder and Discuss Theo Colburn is listed as an author of "Our Stolen Future", and she is referenced to in third person in the chapter we included in this packet. What do you think of this style of writing? An article in "Environmental Science and Technology" asked, "Will 'Our Stolen Future' be another 'Silent Spring?'" Is this book a good example of activist science writing by a scientist on the ranks of 'Silent Spring?' Do you think the subject of endocrine disruptors became of more interest to the public when the focus shifted from wildlife to human life effects? What role do you think the media played in this? Sharpe and Skakkebaek published their article in "Lancelot" in 1993; a whole body of literature exists that disagrees with their work. Does this article in any way function as Walter Alvarez’s work did (in other words, as a catalyst for more research on estrogen and endocrine disruptors? Check out the "Wall Street Journal" essay by Stephen Safe (8/20/97). Safe is a co-author of some of the work done on disproving endocrine disruptor effects on humans. After all you’ve read, what do you think of the tiny essay by Diane Katz in the corner?

82. Affinity Binding Database For Endocrine Disruptors AFDB Binding Affinity Database for endocrine disruptors. This databaseis developed by bioinformatics group of NIHS. Any comments http://moldb.nihs.go.jp/eddb/afdb/

AFDB : Binding Affinity Database for Endocrine Disruptors This database is developed by bioinformatics group of NIHS . Any comments should be sent to nakata@nihs.go.jp . Please Register before starting search! Document of this database (Japanese) Examples of Database Queries : Explanation for Database Fields Names Please use for a wild card. Mode of Action Competitive Binding Enzyme Induction Relative Binding Affinity - input numbers from to 10000000000 - more than and less than Ligand and Receptor Type in a box or click HELP to find out proper words. Receptor HELP Xenobiotic Chemical HELP Only in ENZYME INDUCTION Induced Enzyme Species (Default is all species) All Human Mouse Rat Experimental Conditions Type in a box or click HELP to find out proper words. Reaction Mixture HELP Method HELP Measurement HELP Detection HELP

83. U.S.-EU Discussions On Endocrine Disruptors 050800 US/EU TECHNICAL DISCUSSIONS ON endocrine disruptors. 3. International cooperationregarding public communication on endocrine disruptors would be beneficial. http://www.useu.be/ISSUES/endoc0508.html

US/EU TECHNICAL DISCUSSIONS ON ENDOCRINE DISRUPTORS Date: May 8, 2000 Brussels, Belgium Points of Agreement 1. Adequate resources should be devoted to the OECD Working Group activities on validation and test development. 2. The proposed Second US/EU Transatlantic Environment Conference on Chemicals should include endocrine disruptors as a major agenda item. 3. International cooperation regarding public communication on endocrine disruptors would be beneficial. 4. Continuation of US/EU collaboration on endocrine disruptor research is vitally important. Funding of specific endocrine disruptor research projects is important in both the US and the EU. Action Items 1. Where possible, the US/EU will collaborate on public communication regarding endocrine disruptors. 2. Discussions covering US/EU collaboration on sharing information regarding appropriate technical criteria for priority setting for endocrine disruptors should be initiated. 3. The US and EU will continue to the maximum extent possible to support the OECD harmonization of international test guidelines and will seek to minimize the use of laboratory animals to the greatest extent possible. The US and EU will share jointly and with the OECD information regarding screening and testing. 4. The proposed EU Workshop on endocrine disrupters, provisionally planned for Spring 2001 in the context of the follow-up of the Community Strategy on endocrine disrupters , will include international collaboration as an agenda item, with appropriate participation of the US.

84. Endocrine Disruptors And The Transgendered privately Here. endocrine disruptors and the Transgendered by ChristineJohnson © 2001-2002 Printer Friendly Document. Despite http://www.transadvocate.org/articles/wfp1.htm

Endocrine Disruptors and the Transgendered by Christine Johnson Printer Friendly Document Despite popular opinion and negative media portrayals which disparage transgendered people as being “mentally ill” or making “lifestyle choices,” an increasing amount of evidence is surfacing which is linking the proliferation of endocrine disrupting chemicals (EDC’s) to variations in gender identity and sexual orientation. In an invited paper published in the December 2001 issue of Neuroendocrinology Letters, Dr. Gunter Dorner outlines the various purported causes of transsexualism, which fall into two general classes: 1) genetic enzyme mutations and 2) so-called epigenetic effects which include stressful prenatal/postnatal situations and fetal exposure to endocrine disruptors such as the pesticide DDT and its breakdown products. ( http://www.nel.edu/22_6/NEL220601R02_Dorner.htm The authors studied the prevalence of polycystic ovaries (PCO), idiopathic oligospermia [low sperm count with no identified cause] (IO), and transsexualism (TS) in East and West Germany over the last 50 years, and correlated increases in these conditions with the use of DDT in the two countries. They found that after 1960, (when DDT usage was high) “clearly increased dehydroepiandrosterone sulfate [DHEA-s] levels and ratios to cortisol were found, suggesting again the possible co-responsibility of DDT and its metabolites for the development of transsexualism.” They also found that PCO commonly occurred in combination with female-to-male transsexualism, and IO typically occurred in combination with male-to-female transsexualism, suggesting multiple effects from endocrine disruption.

85. Screening And Testing For Endocrine Disruptors Screening and testing for endocrine disrupters. The definition of an endocrinedisrupter has been at the center of the debate from the beginning. http://pubs.acs.org/hotartcl/ac/98/aug/endo.html

August 1, 1998; pp. 528 A-532 A. Screening and testing for endocrine disrupters Science lags behind U.S. legislative demands. R eproductive abnormalities in wildlife, increasing breast cancer in women, decreasing sperm counts in mencould they all have a common link? Many scientists and politicians think so and are pointing to pesticides and other chemicals that disrupt the endocrine system as the underlying thread. Determining which chemicals are responsible is difficult, however, because analytical methods for testing these so-called endocrine disrupters are scarce, and the ones that do exist are far from routine. In the United States, the lobbying of women's rights activists demanding more breast cancer research and environmentalists pushing to protect wildlife was enough to force the U.S. Environmental Protection Agency (EPA) to take a closer look at endocrine disrupters. Before the agency had even gotten its feet wet, two bills were passed by Congress in August 1996the Food Quality Protection Act (FQPA) and amendments to the Safe Drinking Water Act (SDWA) ( Anal. Chem.

86. International Water Association - IWA - Events Page - Workshop On Endocrine Disr This workshop on endocrine disruptors was a part of the programme at the IWA 3rdWorld Water Congress held in Melbourne, Australia, 712 April 2002. http://www.iwahq.org.uk/template.cfm?name=edworkshop

87. Information And Computing Infrastructure For Endocrine Disruptors Information and Computing Infrastructure for endocrine disruptors. From thesepreliminary lists of endocrine disruptors a database was produced. http://www.nihs.go.jp/hse/endocrine-e/paper/1999-1.html

Information and Computing Infrastructure for Endocrine Disruptors Tsuguchika Kaminuma*, Takako Takai-Igarashi, Tatsuya Nakano, and Kotoko Nakata Division of Chem-Bio Informatics, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan *To whom questions will be forwarded. kaminuma@nihs.go.jp Summary The so called endocrine disruptors become an important working hypothesis for a wide range of toxicology researchers. This hypothesis has also attracted those who have worked on designer estrogens or selective estrogen receptor modulators. Already numbers of substances have been identified as such chemicals, but there remain a large number of chemicals waiting for testing their endocrine modulating capabilities. Because of time and costs required for wet lab tests, it is unrealistic to apply these kinds of tests to all such suspicious or probable chemicals. Thus some theoretical methods such as informatics or molecular computing must be developed for this purpose. The conventional QSAR (quantitative structure activity relationships) approach is of limited relevance for this problem, because these methods do not take detailed mechanism of disturbance of biological systems into account. Though knowledge and data on such mechanism are yet insufficient, there already exists new tools for this purpose. We are tying to integrate the existing databases as the base for computer-based pre-screening methodology. The main components of this database complex are a potential endocrine disruptor database, a receptor database, a cell signaling network database, a transcription database, and an affinity binding database based on modes of actions. A metabolic pathway database is under consideration for adding. These databases are linked by an index database and WWW technology. Part of the prototype system has been put on the Internet. Such a complex system might be useful not only for theoretical studies but also for experimental studies.

88. ToxSYS - Screenshot - Endocrine Disruptors http://www.scivision.com/gProdPage/tScreens/ToxSysShots/Shot03.html

89. Endocrine Disruptors Group University Of Missouri-Columbia Illumination Article: Other Links. back to a s news. EDG logo endocrine disruptors Group. Next TheBeginning Naturally Occuring Hormones . endocrine disruptors Group logo. http://rcp.missouri.edu/articles/toxicavenger/illumarticle.html

Other Links Endocrine Disruptors Group By suggesting that a chemical used in polycarbonate plastics might harm human fetuses, Frederick vom Saal has incurred the wrath of powerful corporate interests. Story by Jo Craven McGinty rederick vom Saal, a biologist and professor at the University of Missouri-Columbia, has been studying fetal development since the mid-1970s. For most of this time, he has labored undisturbed in university settings while gaining attention among the scientific community for his ground-breaking studies on the effects of hormones on fetal development. In 1995, vom Saal's sanguine existence ended abruptly when the plastics and chemical industry revealed to him a newfound interest in his work. In the five years since, that group has spent time, money and substantial effort to dispute vom Saal's research. This kind of industry focus, vom Saal and other say, can ruin a scientist – particularly one who won't shut up about a subject. And Frederick vom Saal won't shut up. Next: The Beginning - Naturally Occuring Hormones from Illumination - Research, Scholarship and Creative Achievement

90. Environment Agency - Endocrine Disruptors Monday 17 March 2003, You are in About Us What's happening Publishing News publications Focus and forward look endocrine disruptors. http://www.environment-agency.gov.uk/aboutus/275292/234805/237584/focus/300634?l

91. Endocrine Disruptors And Reproduction Followups Post Followup Embryology Out Loud Help . endocrine disruptorsand Reproduction. Posted by Dede Lyons on November 20, 2001 at 164911 http://www.mtholyoke.edu/courses/rfink/305-discussion2/messages/39.html

Followups Post Followup Embryology Out Loud Help Endocrine Disruptors and Reproduction Posted by Dede Lyons on November 20, 2001 at 16:49:11: Heather and I are interested in exploring how agents in our extrinsic environment can influence our intrinsic environment and affect, for example, human reproduction. In the past 40 year or so people have discovered that chemicals and exogenous and synthetic hormones in the environment can act as endocrine disruptors that disturb the body's natural hormonal balance. Endocrine disruptors are particularly dangerous to the reproductive system, causing abnormalities and fatal diseases in adults and embryos of many animals, including humans. Heather and I would like to research for example, the regulation endocrine disruptors in the environment and in man-made products. Known endocrine disruptors are present in things that we buy and use very day (e.g. plastic), and their continued use raises questions about reproductive health and responsible consumerism. Followups Post a Followup Name: Email: Subject: Comments: : Heather and I are interested in exploring how agents in our extrinsic environment can influence our intrinsic environment and affect, for example, human reproduction. In the past 40 year or so people have discovered that chemicals and exogenous and synthetic hormones in the environment can act as endocrine disruptors that disturb the body's natural hormonal balance. Endocrine disruptors are particularly dangerous to the reproductive system, causing abnormalities and fatal diseases in adults and embryos of many animals, including humans. Heather and I would like to research for example, the regulation endocrine disruptors in the environment and in man-made products. Known endocrine disruptors are present in things that we buy and use very day (e.g. plastic), and their continued use raises questions about reproductive health and responsible consumerism.

92. Biological Activity Of Complex Mixtures Of Endocrine Disruptors researchproject. Biological activity of complex mixtures of endocrinedisruptors. The presence of endocrine disruptors in the environment http://www.research-projects.unizh.ch/vet/unit51000/area671/p2728.htm

research project Biological activity of complex mixtures of endocrine disruptors The presence of endocrine disruptors in the environment has become a major issue of public concern in Switzerland and many other countries. Environmental pollutants with endocrine activity have been linked to reduced birthrates in wildlife and loss of biodiversity. Endocrine disruptors have also been associated with diseases in humans including reproductive disorders and cancer. However, an unequivocal assessment of hazards and magnitude of risk due to endocrine disruptors is not yet possible, mainly because of inadequate knowledge of their adverse effects at low-dose levels. In view of this information gap, we are using a functional genomic approach to identify molecular pathways and endpoints induced in critical target cells by low-dose mixtures of endocrine disruptors. Index Terms PCB, dioxin, estrogens, antiestrogens, hormones, Ah receptor Contacts PD Dr. Hanspeter Naegeli (Project Leader) naegelih@vetpharm.unizh.ch Research Program NFP Duration Apr 2002 to unknown Last Update Responsible Professor or Research Area Leader: PD Dr. Hanspeter Naegeli

93. Assessment Of The Endocrine Disruptors In The Naval Environment Assessment of the endocrine disruptors in the Naval Environment. Authors.GB Briggs KR Still WW Jederberg. The Navy has a risk reduction http://www.navy.al.wpafb.af.mil/resabs/briggs2.html

Assessment of the Endocrine Disruptors in the Naval Environment. Authors G. B. Briggs K. R. Still W. W. Jederberg The Navy has a risk reduction program that provides occupational health professionals with guidance that stresses reproductive health. The NMRVTD is responsible for developing the data necessary to characterize the toxicity of materials of interest to the Navy and formulates occupational and environmental health hazard evaluations and risk assessments. A growing body of evidence has begun to suggest that chemicals in the public environment may be producing adverse health effects by disrupting endocrine system function. The Navy is correlating research with the CENR Endocrine Disruptor Work Group to determine potential health and ecological effects, risk uncertainties and research needs. Results of activities to develop methods and predictive models and measurements will be presented. Presented at the 1997 Society of Toxicology (SOT) Annual Meeting, Cincinnati, Ohio; 8 March 97 Let us know what you think about this page! Back to Abstract Index

94. Endocrine Disruptors - Invisible Saboteurs Of Our Health And Survival endocrine disruptors INVISIBLE SABOTEURS OF OUR HEALTH AND SURVIVAL.by E. Dowdeswell A mystery story is unfolding. The story of http://www.unep.org/unep/products/oed/oped3.htm

ENDOCRINE DISRUPTORS - INVISIBLE SABOTEURS OF OUR HEALTH AND SURVIVAL by E. Dowdeswell A mystery story is unfolding. The story of the invisible undermining of our future by endocrine disruptors is being written, but the ending is not yet clear. Piecing together chilling evidence from wildlife studies, laboratory experiments and human data, "Our Stolen Future" by Colborn and Dumanoski portrays these synthetic chemicals as suspects disrupting the reproductive, immune and behaviour systems of wildlife and human beings. The endocrine system produces hormones which are chemical messengers directing how and when cells grow, produce bodily substances, and die. By whatever name you call them: xenoestrogens, copy cat hormones, gender benders, estrogenic compounds or environmental hormone disruptors, this new class of chemicals poses a life altering challenge. Strong evidence of defective sexual organs, behavioral abnormalities and impaired fertility exists. It must be taken seriously. In the early 50's Florida's bald eagles lost their natural instinct to mate and raise their young. In the mid 60's the reproductive failure of mink around Lake Michigan was linked to PCBs. Sexual abnormalities of alligators in Lake Apopka, Florida followed a pesticide spill. From herring gulls to turtles, to frogs, a disturbing pattern of deformity emerges. The evidence is not limited to effects on animals. Why have human male sperm counts dropped by as much as 50 per cent in recent decades? Why are women suffering a dramatic rise in hormone-related cancers?

95. Toxicology & Environment endocrine disruptors the endocrine theory. 10)endocrine disruptors LowDosePeer Review (NIEHS National Toxicology Program's Report, August 2001). http://w3.uniroma1.it/MEDICFISIO/edc.htm

Department of Medical Physiopathology Biofluorimetry Lab University of Rome 'La Sapienza' ENDOCRINE DISRUPTING CHEMICALS with the last 6-months titles/abstracts published in leading J ournals other Site's Areas Agencies - Homepages - Institutions Organizations - Web resources A gencies (government) USA International A merican Plastics Council A TSDR - Agency for Toxic Substances and Disease Registry A TSDR's Hazardous Substance Release/Health Effects Database C ERHR - Center for the Evaluation of Risks to Human Reproduction C hemical Industry Homepage D anish Environmental Protection Agency E COTOX Database System E ndocrine Disruptors E ndocrine Disrupters Assessment Activities (OECD) E ndocrine disruptor related sites E ndocrine disruptors E ndocrine disruptors (Illinois EPA) E ndocrine disruptors (actions in Europe) E ndocrine Disruptors (Detecting) E ndocrine disruptors Beauty Secrets E ndocrine Disruptors Block Sperm Function - New Evidence That E ndocrine Disruptors Page E ndocrine disruptors: Agents under study end End Points E ndocrine disruptors binding affinities database E ndocrine disruptors (risk and extent) E ndocrine Disruptor Research Initiative Project Inventory pages (EPA) E ndocrine disruptors: the endocrine theory E ndocrine Disruptors (Information and Computing Infrastructure for) E ndocrine Disruptors Research Initiative E ndocrine Disruptor Screening Program; Proposed Statement of Policy

96. ENDOCRINE DISRUPTORS AND OTHER SCARY THINGS DJC. endocrine disruptors AND OTHER SCARY THINGS. BY CANDICE DOUGLAS,MICHAEL MOORE and ROSALIND SCHOOF PTI Environmental. Protecting http://www.djc.com/special/enviro96/10014103.htm

ENDOCRINE DISRUPTORS AND OTHER SCARY THINGS BY CANDICE DOUGLAS, MICHAEL MOORE and ROSALIND SCHOOF PTI Environmental Protecting the environment is a complex and often controversial issue. That is why the application of scientific principles and the appropriate use of scientific research are critical when evaluating real risks versus perceived risks from exposure to chemicals. The great apple scare of 1989 over the use of the pesticide Alar is a prime example of how misinterpreting scientific research can result in huge repercussions. The apple industry lost millions of dollars, Alar was banned and the apple growers filed a $200 million lawsuit against the organizations that initiated the scare. How estrogen influences organisms. When the dust finally settled, we learned that the scientific information used to support this huge scare was based on the inaccurate analyses of research on mice conducted in 1977. In addition, the analyses falsely interpreted animal results to predict human cancer risk. For the environment, the real tragedy is that Alar was banned and replaced with potentially more toxic chemicals. The Alar situation clearly demonstrates the importance of understanding and correctly interpreting scientific data when evaluating the effects of chemicals on human health and the environment.

97. [OEM] NIEHS/NTP: Update On Methodology For Endocrine Disruptors OEM NIEHS/NTP Update on methodology for endocrine disruptors Greenberg@DUKE.EDU ;Subject OEM NIEHS/NTP Update on methodology for endocrine disruptors; http://hazard.com/mail/oem-new/msg00037.html

Date Prev Date Next Thread Prev Thread Next ... Thread Index [OEM] NIEHS/NTP: Update on methodology for endocrine disruptors Expert Panel Evaluation of the Validation Status of In Vitro Test Methods for Detecting Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays http://iccvam.niehs.nih.gov/ http://iccvam.niehs.nih.gov/methods/endodocs/final/panelrpt.pdf Gary N. Greenberg, MD MPH Sysop / Moderator Occ-Env-Med-L MailList OEM-L Maillist Website: http://occhealthnews.net Please remove this footer before replying. Visit http://www.siouxlan.com/acoem/ ACOEM's Private Practice Section The mission of the Section is to provide the highest quality, and most cost efficient occupational and environmental medical care to employees and their employers in order to obtain the safe and quick return to work and life activities. Prev by Date: [OEM] L. A. Times: Worker Safety Is a Matter of Contention at Ports Next by Date: Re: [OEM] Return to Work Estimates Previous by thread: [OEM] L. A. Times: Worker Safety Is a Matter of Contention at Ports

98. WWF Endocrine Disruptor Information Papers and speeches on how hormone disruptors interfere with biochemical processes, and a suspected list of hormone disruptors. http://www.pmac.net/theos.htm

Pesticides as Endocrine Disruptors WWF Endocrine Disruptor Information Dr. Theo Colborn, a leading scientist and expert on endocrine disruptors, has co-authored Our Stolen Future with Dianne Dumanoski and John Peterson Myers. STATE OF THE WORLD FORUM Dr. Theo Colborn, November 6, 1997, San Francisco CA. Evolutionary differences between natural and synthetic estrogens are discussed in a fascinating November 16, 1997 post to the Sanet discussion group by Dr. Ann Clark, University of Guelph. Dr. Clark reflects upon information in Our Stolen Future and offers examples cropping-livestock systems of how animals respond differently to plant estrogenic compounds they have evovled with, in contrast to those introduced into their environment from an exogenous source. WWF - Hormone Disruptor site with information on how hormone disruptors interfere with bio-chemical processes, the wildlife- human connection, a known and suspected list of hormone disruptors and an audio clip from Dr. Theo Colburn as she explains endocrine disruption and it's hazards "Acceptance Speech" , Dr. Theo Colborn, delivered June 19, 1997, upon receipt of the

99. Endocrine Disrupters From the Whyfiles, a study by the Environmental Protection Agency about synthetic chemicals causing Category Kids and Teens School Time Humans endocrine System......what are they? Wildlife woes Pesticides don't discriminate Human woes DES, DDT,PCB's, dioxin 'n more. How does the endocrine system work? Hormone basics http://whyfiles.org/045env_hormone/

In July, an EPA committee met in Chicago. Their problem: are synthetic chemicals causing hormonal chaos? [Posted August 7, 1997] Wildlife woes : Pesticides don't discriminate Human woes : DES, DDT, PCB's, dioxin 'n more Hormone basics Hormone confusion : How disrupters do their work History : DDT and eagles' eggs The EPA's action plan Prospects for success There are documents. Bibliography Credits Search

100. Endocrine Disrupters In July, an EPA committee met in Chicago. Their problem are synthetic chemicals causing hormonal chaos? Posted August 7, 1997 Human woes DES, DDT, PCB's, dioxin 'n more http://whyfiles.news.wisc.edu/045env_hormone

In July, an EPA committee met in Chicago. Their problem: are synthetic chemicals causing hormonal chaos? [Posted August 7, 1997] Wildlife woes : Pesticides don't discriminate Human woes : DES, DDT, PCB's, dioxin 'n more Hormone basics Hormone confusion : How disrupters do their work History : DDT and eagles' eggs The EPA's action plan Prospects for success There are documents. Bibliography Credits Search

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