81. PAG-X: GENETICS OF MITOCHONDRIAL-NUCLEAR INTERACTIONS IN ARABIDOPSIS Workshop Organellar genetics. genetics OF mitochondrialNUCLEAR INTERACTIONSIN ARABIDOPSIS. Lee Mcintosh 1 , Jianping Yu 1 , Roxy Nickels 1 http://www.intl-pag.org/10/abstracts/PAGX_W232.html

January 12-16, 2002 San Diego, CA Workshop: Organellar Genetics GENETICS OF MITOCHONDRIAL-NUCLEAR INTERACTIONS IN ARABIDOPSIS Lee Mcintosh Jianping Yu Roxy Nickels MSU-DOE Plant Research Laboratory Michigan State University East Lansing, MI 48824 Return to Previous Page or Intl-PAG Homepage

82. Ronald A. Butow, Ph.D., Genetics And Development We are studying the molecular genetics of mitochondrial biogenesis and theinteractions of mitochondria with other cellular components in the yeast http://swnt240.swmed.edu/gradschool/webrib/butow.htm

Ronald A. Butow, Ph.D. Professor of Molecular Biology Genetics and Development Office: (214) 648-1465 FAX: (214) 648-1488 Email: butow@utsw.swmed.edu We are studying the molecular genetics of mitochondrial biogenesis and the interactions of mitochondria with other cellular components in the yeast, Saccharomyces cerevisiae. One major area of investigation is an understanding of how mitochondrial DNA is faithfully transmitted during cell division. To approach this problem, we are analyzing the organization, replication and dynamics of the mitochondrial chromosome. The working hypothesis is that there is a dedicated mitochondrial DNA segregation apparatus in yeast that controls mitochondrial DNA transmission. We use a variety of biochemical, genetic, reverse genetic and cell biological approaches to study mitochondrial DNA transmission and to identify the cis and trans -acting components that function in the inheritance of the mitochondrial chromosome. A second major area of investigation centers on the interactions between the nucleus and mitochondria and the mechanisms that control mitochondrial homeostasis in the cell. These studies involve the analysis of nuclear genes that are important for the control of mitochondrial gene expression, and how the cell monitors and responds to changes in the functional state of mitochondria. The latter response was discovered in our laboratory and is a pathway called retrograde regulation , which is defined by the observation that changes in the functional state of mitochondria alter the expression of a large subset of nuclear genes. We have shown that these changes reflect attempts by the cell to accommodate metabolic and biosynthetic activities to alterations in the functional state of mitochondria. Current studies focus on identifying the signals that mark changes in the functional state of mitochondria, and how these signals are transmitted to the nucleus to effect changes in gene expression.

83. THE MERCK MANUAL, Sec. 21, Ch. 286, General Principles Of Medical Genetics Nontraditional Inheritance. Chromosomal Disorders. mitochondrial DNA Abnormalities.Cancer genetics. Immunogenetics. Forensic genetics. Genetic Therapy. http://www.merck.com/pubs/mmanual/section21/chapter286/286a.htm

This Publication Is Searchable The Merck Manual of Diagnosis and Therapy Section 21. Special Subjects Chapter 286. General Principles Of Medical Genetics Topics [General] Inheritance Of Single-Gene Defects Multifactorial Inheritance Nontraditional Inheritance ... Genetic Therapy [General] Human development depends on genetic and environmental factors. A person's genetic composition (genome) is established at conception. The genetic information is carried in the DNA of the chromosomes and mitochondria. Most diseases probably have some genetic component, the extent of which varies. Environmental factors may alter genetic information through mutation or other structural alteration and can affect classic genetic disorders (eg, dietary management in phenylketonuria, drugs for hypercholesterolemia). DNA's capacity to replicate constitutes the basis of hereditary transmission. DNA also provides the genetic code, which determines cell development and metabolism by controlling RNA synthesis. The sequence of the elements (nucleotides) that comprise DNA and RNA determines protein composition and thus its function. Genes, the basic units of heredity, are arranged linearly within the DNA along the chromosomes; each gene has a specific location (locus) or position on the chromosomes. The number and arrangement of loci on homologous chromosomes are usually identical. However, the structure of a specific gene may have minor variations (polymorphisms) without causing disease. The specific nucleotide sequence of the genes that occupy the two homologous loci along the two chromosomes of a pair are called alleles. The two alleles (ie, the one inherited from the mother and the one inherited from the father) may have slightly different nucleotide sequences or may be the same. A person with a pair of identical alleles for a particular gene is a homozygote; a person with a pair of dissimilar alleles is a heterozygote.

84. Christiane M.-R. Fauron, Research Assistant Professor Of Human Genetics Kluwer Academic press. pp159. 4. Fauron CM-R, Casper M (1994) A second typeof maize mitochondrial genome an evolutionary link. genetics 137875-882. http://www.bioscience.utah.edu/mb/mbFaculty/fauron/fauron.html

Christiane M.-R. Fauron Research Assistant Professor of Human Genetics Research References No email address available. No lab web page available. Research The focus of our research is to understand the organization, the function and the evolution of the maize ( Zea mays Zea mays ssp. Parviglumis , the probable progenitor of maize, and Zea perennis from the most distant section of the teosintes) will be sequenced and compared to the sequences of a more distant relative, Tripsacum Tripsacum dactyloides ). A direct sequencing approach is complemented with the mapping of several Zea mitochondrial genotypes using an efficient cosmid fingerprinting strategy to construct maps and identify regions of rearrangement and divergence. The probable gene contents will be inferred from searches of other mitochondrial and microbial database entries, and will be compared among all the sequenced Zea mitochondrial genotypes. The regions of the maize mitochondrial genome that are functional will be determined by expression analyses using mitochondrial RNAs from different tissues and stages of development. There is evidence that some mitochondrial genes may be expressed preferentially during specific stages of development. We want to determine the set of mitochondrial genes that are expressed during the life cycle of maize.

85. Medical Genetics - Mitochondrial Inheritance: Leber's Optic Atrophy mitochondrial Inheritance Leber's Optic Atrophy. http://www.mccg.org/childrenshealth/genetics/mitochon.asp

About MCCG News MCCG Careers Health Careers ... Home You are here Home Children's Health Medical Genetics Inside Children's Health SEARCH Children's Health Children's Health Home Adolescent Medicine Allergy, Asthma and Immunology Pediatric Arthritis and Other Rheumatic Diseases Burns Cardiovascular Disorders Craniofacial Anomalies Dental and Oral Health Dermatology Diabetes and Other Endocrine Metabolic Disorders Digestive and Liver Disorders Ear, Nose and Throat Eye Care Medical Genetics Growth and Development Hematology and Blood Disorders High-Risk Newborn High-Risk Pregnancy Infectious Diseases Child and Adolescent Mental Health Neurological Disorders Normal Newborn Oncology Orthopaedics Common Childhood Injuries and Poisonings Pregnancy and Childbirth Respiratory Disorders Safety and Injury Prevention The Child Having Surgery Care of the Terminally Ill Child Transplantation Genitourinary and Kidney Disorders Mitochondrial Inheritance: Leber's Optic Atrophy What is mitochondrial inheritance? The normal 46 chromosomes in our body are contained in the center of the cell, which is called the nucleus. Mitochondria are structures in the cell located outside of the nucleus in the cytoplasm, that also contain genes that are separate from the ones in the nucleus.

86. Medical Genetics - Mitochondrial Inheritance: Leber's Optic Atrophy mitochondrial Inheritance Leber's Optic Atrophy. What is mitochondrialinheritance? The normal 46 chromosomes in our body are contained http://www.uuhsc.utah.edu/healthinfo/pediatric/genetics/mitochon.htm

Mitochondrial Inheritance: Leber's Optic Atrophy What is mitochondrial inheritance? The normal 46 chromosomes in our body are contained in the center of the cell, which is called the nucleus. Mitochondria are structures in the cell located outside of the nucleus in the cytoplasm, that also contain genes that are separate from the ones in the nucleus. Unlike nuclear genes, which are inherited from both parents, mitochondrial genes are inherited only from the mother. If there is a mutation in a mitochondrial gene, it is passed from a mother to all of her children; sons will not pass it on, but daughters will pass it on to all of their children, and so on. The first human disease that was associated with a mutation in mitochondrial DNA is called Leber’s Hereditary Optic Neuropathy, or LHON. What is Leber's hereditary optic neuropathy (LHON)? LHON causes a painless loss of central vision between 12 and 30 years of age. Both eyes are affected at the same time. Males will not pass the gene to any of their children, but females with the mutation will pass it to all of their children, regardless of whether they are sons or daughters. Click here to view the Online Resources page of this Web.

87. Medline Record 93173296 mutations may assume a pathogenetic role with aging. Major IndexesDNA, mitochondrial genetics; mitochondrial Myopathies genetics; http://avsunxsvr.aeiveos.com/agethry/dnadmgrp/93173296.html

Title: Mitochondrial DNA alterations as a source of human disorders. Author(s): Tritschler HJ; Medori R Address: Clinica Neurologica, Universita di Bologna, Italy. Source: Neurology 1993 Feb;43(2):280-8 Abstract: Major Indexes: DNA, Mitochondrial [genetics] Mitochondrial Myopathies [genetics] Mutation [genetics] Minor Indexes: Aging [genetics] DNA Mutational Analysis DNA Repair [genetics] DNA, Mitochondrial [drug effects] Point Mutation [genetics] Reagent Names: (DNA, Mitochondrial) Language: English Periodical Type: JOURNAL ARTICLE; REVIEW (131 references); REVIEW, ACADEMIC

88. Mitomap MITOMAP. A human mitochondrial genome database. A compendium of polymorphisms and mutations of the human mitochondrial DNA the mitochondria. mitochondrial References (AZ) (1 MB) http://www.gen.emory.edu/

MITOMAP Has Moved! MITOMAP is no longer operated at this URL. It has been relocated to: http://www.mitomap.org Please update your bookmarks. You will be redirected to the new URL automatically in 5 seconds. If you are not redirected, please click the link above.

89. Scientists Of The Dept. Molecular Genetics inherited diseases, monogenic mutations, maternal inheritance, mitochondrialgenetics, transgenic animals, ceruloplasmin, copper metabolism. http://www.iemrams.spb.ru:8100/english/molgen/genpers.htm

Scientists of the Department person field of research Vadim B. Vasilyev prof.,M.D., Ph.D inherited diseases, monogenic mutations, maternal inheritance, mitochondrial genetics, transgenic animals, ceruloplasmin, copper metabolism Andrei P. Dyban prof., M.D., Ph.D inherited diseases, maternal inheritance, developmental biology, chromosomal aberrations, early embryogenesis Eugene L. Patkin prof.,Ph.D developmental biology, early embryogenesis, inherited diseases, regulation of gene expression Ludmila V. Puchkova prof.,Ph.D inherited diseases, monogenic mutations, ceruloplasmin, copper metabolism Mikhail M. Shavlovski prof.,M.D.,Ph.D. monogenic mutations, inherited diseases, ceruloplasmin, lactoferrin, gene therapy Nadejda V.Tsymbalenko Ph.D. inherited diseases, copper metabolism during development, gene cloning Natalia A. Platonova, Ph.D. nplatonova2000@mail.ru

90. Publications Presented at the 1998 American genetics Association Symposium Plant Mitochondrialgenetics and Molecular Biology for the Journal of Heredity 90380385. http://www.public.iastate.edu/~imagefpc/Subpages/publications.html

Recent Publications * indicates corresponding author - Plant-Pathogen Interactions- Halterman, D, F Wei, and RP Wise* . 2003. Powdery mildew induced Mla mRNAs are alternatively spliced and contain multiple upstream open reading frames. Plant Physiology 131: 558-567. [Abstract] Wei, F, R Wing, and RP Wise *. 2002. Genome dynamics and evolution of the Mla (powdery mildew) resistance locus in barley. Plant Cell 14:1903-1917. [Abstract] Halterman, D, F Zhou, F Wei, RP Wise* , and P Schulze-Lefert. 2001. The MLA6 coiled-coil, NBS-LRR protein confers -dependent resistance specificity to Blumeria graminis f. sp. hordei in barley and wheat Plant Journal 25:335-348. [Abstract] R Wise , and P Schulze-Lefert*. 2001. Cell-autonomous expression of barley confers race-specific resistance to the powdery mildew fungus via a independent signaling pathway. Plant Cell 13:337-350. [Abstract] Yu, GX, Braun, E, and RP Wise Rds and Rih mediate hypersensitive cell death independent of gene-for-gene resistance to the oat crown rust pathogen, Puccinia coronata f. sp.

91. Eccles Institute Of Human Genetics - Christiane M.-R. Fauron 1995 Jun;11(6)22835. Review. Fauron CM, Casper M. A second type of normal maizemitochondrial genome an evolutionary link. genetics. 1994 Jul;137(3)875-82. http://www.genetics.utah.edu/faculty/cfauron.html

Christiane M.-R. Fauron, Ph.D. Research Assistant Professor Contribution to Society Mitochondria are the site of most of the energy production in eukaryotic cells; they help to turn food into chemical energy in cells of plants and animals and for this reason have been called the "powerhouse of the cell". In addition, the mitochondria are essential for metabolic functions that help each tissue to perform its role. Although the nucleus contains the vast majority of the cell's genes, mitochondria have their own DNA, coding for proteins whose functionality are vital for the survival of cells. Mitochondrial dysfunction has been implicated in numerous diseases and a better understanding of their organization and function will lead to more effective therapeutic approaches to these diseases Research Summary Recent Publications Fauron C, Casper M, Gao Y, Moore B. The maize mitochondrial genome: dynamic, yet functional. Trends Genet. 1995 Jun;11(6):228-35. Review. Fauron CM, Casper M. A second type of normal maize mitochondrial genome: an evolutionary link. Genetics. 1994 Jul;137(3):875-82. Sangare A, Weil JH, Grienenberger JM, Fauron C, Lonsdale D. Localization and organization of tRNA genes on the mitochondrial genomes of fertile and male sterile lines of maize. Mol Gen Genet. 1990 Sep;223(2):224-32.

92. Molecular Biology & Genetics At Cornell University, Ithaca, New York. plants. She also has a significant research involvement in the mitochondrialgenetics of higher plants, notably Petunia. Charles http://www.mbg.cornell.edu/grad/gradhistG.html

HISTORY OF GENETICS AND DEVELOPMENT AT CORNELL UNIVERSITY Antonie Blackler The geneticists of the new Section were drawn, for the most part, from the Department of Plant Breeding. This Department had a distinguished history that could be traced back to the era of Rollins A. Emerson and his "school" of maize geneticists of the 1920s and '30s. Emerson's group carried out research that established maize as one of the best known 'genetic' organisms and worked out many extensions of Mendelian principles. Some of Emerson's students and others associated with his group went on to be the most influential geneticists of their generation the Nobel laureates George W. Beadle and Barbara McClintock, and the distinguished geneticists Milislav Demerec, Marcus Rhoades, George Sprague, Charles Burnham, and E.G. Anderson In 1964 the geneticists of the new Section were Bruce Wallace, a population geneticist who did his experimental work with Drosophila ; Harry Stinson, an Oenothera geneticist; and Adrian Srb, a fungal geneticist working primarily with Neurospora . The need for strength in the biochemical aspects of genetics was met by a new faculty appointment

93. Intraspecific Phylogeography: The Mitochondrial DNA Bridge Between Population Ge Intraspecific phylogeography the mitochondrial DNA bridge between population geneticsand systematics. Annual Review of Ecology and Systematics 18489522. http://www.uga.edu/srel/Reprint/1175.htm

SREL Reprint #1175 SREL Reprint #1175 Avise, J.C., J. Arnold, R.M. Ball, E. Bermingham, T. Lamb, J.E. Neigel, C.Z. Reeb, and N.C. Saunders. 1987. Intraspecific phylogeography: the mitochondrial DNA bridge between population genetics and systematics. Annual Review of Ecology and Systematics 18:489-522. To request reprint. document.write('<');document.write('! ');

94. MITOMAP Has Moved! MITOMAP Has Moved! MITOMAP is no longer operated at this URL. It has beenrelocated to http//www.mitomap.org. Please update your bookmarks. http://www.gen.emory.edu/mitomap.html

MITOMAP Has Moved! MITOMAP is no longer operated at this URL. It has been relocated to: http://www.mitomap.org Please update your bookmarks. You will be redirected to the new URL automatically in 5 seconds. If you are not redirected, please click the link above.

95. The Mitochondria Research Society: Contact Us Center, Johns Hopkins School of Medicine. He is an expert on mitochondrialgenetics and has more than 20 years of research experience. http://www.mitoresearch.org/contact1.htm

Contact Us Questions or Comments, Contact Keshav K. Singh, Ph.D. Department of Cancer Genetics Cell and Virus Building, Room 247 Roswell Park Cancer Institute Elm and Carlton Streets Buffalo, NY 14263 Phone: 716-845-8017 Fax: 716-845-1047 Email: keshav@mitoresearch.org Dr. Singh founded the Mitochondria Research Society, is the founding editor-in-chief of the journal Mitochondrion and is instrumental in promoting mitochondrial research and medicine around the world. He is an Associate Professor of Cancer Genetics at Roswell Park Cancer Institute, the nation's first cancer research, treatment and education center. Until recently he was an Assistant Professor of Oncology and Environmental Health at Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine. He is an expert on mitochondrial genetics and has more than 20 years of research experience. In 2001 Dr. Singh was appointed as Honorary Chairman of the Business Advisory Council by the Chairman of the National Republican Congressional Committee, Tom Davis to help represent health issues and provide leadership in biotechnology and small business related to mitochondrial health. Dr. Singh is the author of over 30 research publications and a book entitled Mitochondrial DNA Mutations in Aging, Disease and Cancer. His translational research is aimed at developing methods to identify potential "mitomutagens" present in our environment and agents that are used in therapy of cancer. His basic research is focused on mitochondrial oxidative stress, genomic instability and mutagenesis and its role in pathogenesis of mitochondrial diseases, aging and cancer.

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