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Iga Nephropathy:     more detail

IgA Nephropathy Today (Contributions to Nephrology) by Y. Tomino, 2007-05-31 Iga Nephropathy: From Molecules to Men (Contributions to Nephrology) by Yasuhiko Tomino, 1999 Moderately Proteinuric IgA Nephropathy in the Young (Biomedical and Health Research, V. 44) Iga Nephropathy: The 25th Year (Contributions to Nephrology) Iga Nephropathy: Pathogenesis and Treatment (Contributions to Nephrology) by A. R. Clarkson, 1995-02 Primary IgA Nephropathy: Pathophysiology, Diagnosis, and Clinical Management.: An article from: Nephrology Nursing Journal by Betsy Jane Staples, 2001-04-01 Pulmonary capillaritis in IgA nephropathy.: An article from: Southern Medical Journal by Devanand Anantham, Kenneth P.W. Chan, et all 2007-06-01 IgA Nephropathy - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by ICON Health Publications, 2004-10-08 Iga Nephropathy (Topics in Renal Medicine) Iga Mesangial Nephropathy (Contributions to Nephrology) by G. D'Amico, L. Minetti, 1984-09 The mucosal immune response in primary IgA nephropathy by Johan Willem de Fijter, 1998 Iga Nephropathy: A Medical Dictionary, Bibliography, And Annotated Research Guide To Internet References by Icon Health Publications, 2004

lists with details

41. Nature Publishing Group
    3 pp 354 357 iga nephropathy, the most common cause of glomerulonephritis, islinked to 6q22–23 Ali G. Gharavi 1, 4 , Yan Yan 1 , Francesco Scolari 5 , F  
    http://www.nature.com/cgi-taf/DynaPage.taf?file=/ng/journal/v26/n3/full/ng1100_3

42. ThirdAge - Adam - IgA Nephropathy (Berger¹s Disease)
    iga nephropathy (Berger¹s disease). Definition iga nephropathy (Berger'sdisease) is a form of mesangial proliferative nephritis.  
    http://www.thirdage.com/health/adam/ency/article/000466.htm
    
    Extractions: document.write(''); document.write(''); document.write(''); document.write(''); document.write(''); document.write(''); document.write(''); document.write(''); Activities Computers Family Tree Health ... Prevention Definition: A kidney disorder characterized by blood in the urine ; caused by inflammation of the internal kidney structures and deposits of IgA antibodies in the kidney mesangial tissue. Causes, incidence, and risk factors: IgA nephropathy (Berger's disease) is a form of mesangial proliferative nephritis. Inflammation of the renal glomeruli occurs, and there are IgA (a type of antibody ) deposits in the kidney. The disorder can appear as acute , rapidly progressive, or chronic glomerulonephritis ; or as visible or microscopic hematuria blood in the urine

43. Update - IgA Nephropathy And CD89
    An update on recent devleopments in the study of human iga nephropathy learndoctor.com. IgAnephropathy - Launay et al J Exp Med 2000 191(11)1999-2009.  
    http://www.learndoctor.com/updates/iganephropathy.htm
    
    Extractions: IgA nephropathy - Launay et al J Exp Med 2000 191(11):1999-2009 Medline abstract - in new window Full text article - in new window - a subscription to the journal may be required This disease is a glomerulonephritis and is the commonest primary glomerulonephritis worldwide. Kidney biopsies typically show deposition of IgA in the mesangium of the glomerulus and the proliferation of mesangial cells and increased amounts of mesangial matrix. There are often increases in the amount of circulating IgA in the plasma of patients. The cause of the disease is not fully understood. Several groups now suggest that the molecule CD89 may play a role. This is a receptor for the Fc portion of IgA antibodies. The Fc portion of the molecule is the part that is not normally involved in binding to the foreign antigen. The receptors are involved in binding IgA and transporting it across cells. CD89 is also termed an FcalphaR. A group from the famous Necker hospital in Paris now report in the Journal of Experimental Medicine, that in patients with IgA nephropathy there are high levels of soluble CD89 bound to IgA which circulate in the blood as a complex. They then put the gene for human CD89 into mice and showed that these transgenic mice developed a disease like IgA nephropathy. When serum from these affected mice was administered to unaffected mice, the serum transmitted the disease. Furthermore, if the CD89-IgA complexes were removed from this serum it was unable to transmit the disease. These finding suggest that the presence of high plasma levels of the complex formed between CD89 and IgA can cause a disease in mice similar to human IgA nephropathy. As such high levels are found in patients, but not in normal controls, these complexes may contribute to the pathology of human IgA nephropathy.

44. Health Library - IgA Nephropathy
    iga nephropathy. Synonyms Disorder Subdivisions General Discussion Resources iga nephropathyis a kidney disorder occuring during childhood and young adulthood.  
    http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

45. IgA Nephropathy Foundation
    iga nephropathy Foundation httphttp//www.igan.org/ The IgAN Foundation's missionis to provide vital and the latest information on the diagnosis and  
    http://www.pslgroup.com/dg/dd246.htm

46. Therapeutic Aspects In IgA Nephropathy
    Therapeutic aspects in iga nephropathy. Francesco Paolo Schena, Departmentof Emergency and Transplantation, Division of Nephrology  
    http://www.sin-italia.org/jnonline/forum/forumiga/schena2.htm
    
    Extractions: University of Bari – Italy The guidelines Fig 105 for the management of patients with IgA nephropathy are based on four points: 1. Urinalysis screening of family members; 2. Role of renal biopsy; 3. Out patient follow-up; 4. Rationale for therapy. Fig 106 IgAN is currently diagnosed during a medical check-up for work, military service and security service. Fig 107 In addition two aspects Fig 108 such as biopsy policy and health screening urinary tests play an important role in marking differences of prevalence of this disease in different geographic regions of the world. In fact, IgAN is highly frequent in Japan Fig 109 for the presence of the school health law (since 1973, all students receive urinalysis) (77) and in Singapore where at army recruitment all subjects with persistent microhematuria or recurrent macroscopic hematuria episodes undergo renal biopsy (78). The role of renal biopsy is diagnostic and prognostic.

47. Home
    Markers of Progression in iga nephropathy. Case Presentation (FP Schena L. Gesualdo). Markers of Progression in iga nephropathy (L. Gesualdo).  
    http://www.sin-italia.org/jnonline/forum/07122000.htm
    
    Extractions: L. Gesualdo (Bari Case Presentation (F.P. Schena - L. Gesualdo Markers of Progression in IgA Nephropathy (L. Gesualdo Therapeutic aspects in IgA Nephropathy (F. P. Schena Pathogenetic aspects in IgA Nephropathy (F. P. Schena Discussion References During the next three months, we would like to invite all nephrologists throughout the world to participate in an enlarged discussion with their questions or comments. The two principal discussants will respond to the most relevant questions or comments on the WEB site of the Journal. Please send your e-mail messages to the following address: Giuseppe.Damico@oscb.sined.net . The edited version of this enlarged discussion will be published on the paper edition, in one of the following issues. Besides text and figures, this forum features complete audio and video recording of all sessions:

48. Mayo Clinic - Clinical Trial: Drug Therapy For The Treatment Of IgA Nephropathy
    Drug Therapy for the Treatment of iga nephropathy. A clinical trialcurrently recruiting participants. What is iga nephropathy? IgA  
    http://www.mayo.edu/research/mncg/trial_337.html
    
    Extractions: A clinical trial currently recruiting participants. What is IgA Nephropathy? IgA nephropathy is a kidney disorder caused by deposits of the protein immunoglobulin A (IgA) inside the glomeruli (filters) within the kidney. These glomeruli normally filter waste and excess water from the blood and send them to the bladder as urine. The IgA protein prevents this filtering process, leading to blood and protein in the urine and swelling in the hands and feet. This chronic kidney disease may progress over a period of 10 to 20 years. Why is this research study being done? The purpose of this research study is is to evaluate the safety and benefits of a drug called mycophenolate mofetil (MMF) in patients with IgA Nephropathy. The study has been designed to compare every-day treatment with MMF tablets versus placebo tablets (pills which contain no active medicine) in the treatment of IgA Nephropathy. Men or women that have biopsy diagnosed IgA Nephropathy.

49. New Page 1
    iga nephropathy. iga nephropathy is the commonest primary glomerular disease. Diseaseassociated with iga nephropathy. Skin Diseases. Dermatitis herpetiformis.  
    http://www.thekidney.com/iga.htm
    
    Extractions: THE KIDNEY.COM Home Up Diabetes Stones/ Nephrolithiasis ... Links Search for: IgA NEPHROPATHY IgA nephropathy is the commonest primary glomerular disease. It is seen in about 10 percent of all renal biopsies performed for primary glomerular disease in North America, 20% in Europe, and as high as 30 to 40% in the Asian Pacific area. This may reflect regional differences in the indications for renal biopsy rather than a true difference in geographic incidence. Genetic influence as well as environmental factors may also contribute. It is most common in the second and third decade, However all ages may be affected. Males are more commonly affected (2:1). Can be viewed as a monosymptomatic form of Henoch Schonlein purpura Microscopic or macroscopic hematuria is the commonest manifestation. May follow quickly upon some nonspecific virus-like syndrome or intercurrent infection (e.g. synpharyngitic nephritis) It may be precipitated by upper respiratory tract infection. Proteinuria (usually less than 1 gm per 24 hour). Blood pressure is usually normal.

50. IgA Nephropathy
    iga nephropathy. See Also Berger's Disease, iga nephropathy GlomerularDiseases iga nephropathy is a kidney disorder glomeruli.  
    http://www.health-nexus.com/iga_nephropathy.htm
    
    Extractions: Health-Nexus.Net Health-Nexus.Org The #1 Health information site Search Health-Nexus for: Match ALL words Match ANY word Email this page to a friend ! Post a question or comment on our Message Board Home Page Health Specialties Health News ... Alternative Health Options Substance Abuse Animal Health Search: Books Magazines Video Keywords: Find it Here IgA Nephropathy See Also Berger's Disease IgA Nephropathy A personal story of Darryl who had this disease. From the beginning, to the diagnosis, the kidney transplant and the update.

51. UK NKF - IgA Nephropathy And Renal Failure (Isambard).
    iga nephropathy and renal failure. by Isambard Wilkinson. See Specifically,the disease that I have is iga nephropathy (Berger's). This  
    http://www.kidney.org.uk/Medical-Info/experiences/iga-isambard.html
    
    Extractions: by Isambard Wilkinson See also Kidney Failure: a Personal Account by Isambard. Kidney failure, according to the medical literature, is a 'major life event'. Aged 27 and never having experienced a 'major life event' other than being born, when I learnt two years ago that my kidneys had failed, I was not sure to what pitch of melodrama I should sink. I discovered that I had kidney failure when my eyesight began to fade. I thought that my eyes were infected. I went to the ophthalmology department at the regional hospital. As a matter of course, the doctor took my blood pressure. It was abnormally high. I was wheeled to casualty, where they took blood samples and hooked me up to all sorts of fear-inducing machinery that puffed, beeped and sucked. A young doctor came and sat down on my bed. "Now. It looks quite serious." Gulp. "You have high levels of urea and creatinine (the end product of muscle metabolism) in your blood. Your blood pressure is dangerously high. All the indications point to the possibility that you have kidney failure." I grudgingly let them keep me in overnight. My blood pressure was brought under control and the intricacies of a renal diet were explained to me. I had never given any special thought to my kidneys. But during my first two-and-a-half week stay in hospital, I soon learnt that they have many more functions than just purifying blood. Kidneys are fist-sized organs situated in the small of the back, level with the bottom rib. They keep blood pressure stable, balance the body-fluid volume and filter waste products. They also produce urine to rid the body of waste substances; and hormones to do such things as manufacture red blood cells, so that oxygen can be transported around the body, and convert vitamin D to strengthen the bones. Far from being almost an evolutionary anachronism, as I had vainly hoped, kidneys are vital organs.

52. UK NKF - Kidney Disease
    Nephropathy is a scientific term for kidney disease. What is iga nephropathy? Whatare the symptoms of iga nephropathy? These are variable from case to case.  
    http://www.kidney.org.uk/Medical-Info/kidney-disease/Iga.html
    
    Extractions: What's it really like - patient experiences of IgA Nephropathy IgA is short for Immunoglobulin A, one of the types of antibody our body produces to fight infection. This circulates in the blood. "Nephropathy" is a scientific term for kidney disease. Scarring and inflammation within the kidney, that can only be seen clearly under the microscope. Therefore it is normally only diagnosed after a biopsy test of the kidney. What is seen under the microscope is that the "glomeruli", which are the tiny structures which filter the blood to make urine, are damaged by deposits of IgA. These are variable from case to case. In many cases there are no symptoms, but the damage to the glomeruli causes some blood to appear in the urine. This blood is often invisible, and only detected on routine medical check-ups. In other cases the blood may be visible, coming in attacks every so often. Sometimes an influenza type illness may spark off an attack of blood in the urine, which then clears after a few days.

53. IgA Nephropathy (Berger’s Disease)
    iga nephropathy (Berger’s disease). Definition iga nephropathy (Berger'sdisease) is a form of mesangial proliferative nephritis.  
    http://www.pennhealth.com/ency/article/000466.htm
    
    Extractions: Causes, incidence, and risk factors: IgA nephropathy (Berger's disease) is a form of mesangial proliferative nephritis. Inflammation of the renal glomeruli occurs, and there are IgA (a type of antibody ) deposits in the kidney. The disorder can appear as acute , rapidly progressive, or chronic glomerulonephritis ; or as visible or microscopic hematuria blood in the urine Berger's disease usually is discovered after one or more episodes of dark or bloody urine in a person with no other symptoms of kidney disorder. Bloody urine may begin during or soon after a respiratory infection. Acute nephritic syndrome or nephrotic syndrome (groups of symptoms associated with decreased kidney functioning) may result. Risk factors include having a personal or family history of IgA nephropathy or Henoch Schonlein purpura (a form of vasculitis that affects many parts of the body, and may cause a kidney lesion that is identical to the lesion of Berger's disease).

54. November 2001 - Building The Case For Biopsy In IgA Nephropathy - CAP TODAY
    Building the case for biopsy in iga nephropathy. Firstline treatmentfor newly diagnosed iga nephropathy is ACE inhibitors (ACEI).  
    http://www.cap.org/captoday/archive/2001/feat2_1101.html
    
    Extractions: William Check, PhD Advances in understanding IgA nephropathy , like the disease itself, come in two classes: the slowly progressive type, which is more common, and the less common aggressive form. Consequently, recent reports on this disease contain many preliminary or "promising" findings but fewer firm conclusions. Summarizing a clinical conference on IgA nephropathy that he co-chaired at the 2000 annual meeting of the American Society of Nephrology, J. Charles Jennette, MD, says, "The conference emphasized that there are still a lot of unresolved issues in clinical management, etiology and pathogenesis, and pathological evaluation of IgA nephropathy." Pathogenesis is "one of the most exciting issues," says Dr. Jennette, Brinkhous Distinguished Professor and chair of pathology and laboratory medicine at the University of North Carolina at Chapel Hill. "A potentially very important observation is that there may be abnormalities in the molecular structure of circulating IgA in patients with IgA nephropathy and the closely related disease Henoch-Schönlein purpura, particularly abnormalities in galactosylation in the hinge region of IgA molecules,"

55. Health Ency.: Disease: IgA Nephropathy (Berger's Disease)
    iga nephropathy (Berger's disease). Causes and Risks. iga nephropathy(Berger's disease) is a form of mesangial proliferative nephritis.  
    http://www.accessatlanta.com/shared/health/adam/ency/article/000466.html
    
    Extractions: Important notice Ency. home Disease I IgA nephropathy (Berger's disease) Overview Symptoms Treatment Prevention Alternative names: Nephropathy - IgA; Berger's disease Definition: A kidney disorder characterized by blood in the urine ; caused by inflammation of the internal kidney structures and deposits of IgA antibodies in the kidney mesangial tissue. Causes and Risks IgA nephropathy (Berger's disease) is a form of mesangial proliferative nephritis. Inflammation of the renal glomeruli occurs, and there are IgA (a type of antibody ) deposits in the kidney. The disorder can appear as acute , rapidly progressive, or chronic glomerulonephritis ; or as visible or microscopic hematuria blood in the urine Berger's disease usually is discovered after one or more episodes of dark or bloody urine in a person with no other symptoms of kidney disorder. Bloody urine may begin during or soon after a respiratory infection. Acute nephritic syndrome or nephrotic syndrome (groups of symptoms associated with decreased kidney functioning) may result. Risk factors include having a personal or family history of IgA nephropathy or Henoch Schonlein purpura (a form of vasculitis that affects many parts of the body, and may cause a kidney lesion that is identical to the lesion of Berger's disease).

56. Loyola Univ. Health Sys. - Urology - Immunoglobulin A (IgA) Nephropathy
    Immunoglobulin A (IgA) Nephropathy What is iga nephropathy? What causes iga nephropathy?The IgA protein is a normal part of the body's immune system.  
    http://www.luhs.org/health/topics/urology/iganeph.htm
    
    Extractions: IgA nephropathy is a chronic kidney disease that may progress over a period of 10 to 20 years, and can lead to end-stage renal disease. It is caused by deposits of the protein immunoglobulin A (IgA) inside the glomeruli (filters) within the kidney. These glomeruli normally filter waste and excess water from the blood and send them to the bladder as urine. However, the IgA protein prevents this filtering process. This may lead to the following: What causes IgA nephropathy? The IgA protein is a normal part of the body's immune system. It is unknown what causes IgA deposits in the glomeruli, however, in more than half of families, IgA nephropathy is inherited by an autosomal dominant gene. Autosomal dominant inheritance means that the gene is located on one of the autosomes (chromosome pairs 1 through 22). This means that males and females are equally affected, and “dominant” means that only one gene is necessary to have the trait. When a parent has a dominant trait, there is a 50 percent chance that any child they have will also inherit the trait.

57. IgA NEPHROPATHY ACCOMPANIED BY SILICA-DEPOSITED
    iga nephropathy ACCOMPANIED BY SILICADEPOSITED. INTERSTITIAL NEPHRITIS.Abdur Rauf Khan, MD, FCAP; Mohammed Al-Homrany, FRCPC, FACP.  
    http://www.kfshrc.edu.sa/annals/191/98-177.html
    
    Extractions: IgA NEPHROPATHY ACCOMPANIED BY SILICA-DEPOSITED INTERSTITIAL NEPHRITIS Abdur Rauf Khan, MD, FCAP; Mohammed Al-Homrany, FRCPC, FACP Occupational exposure to silica is associated with clinical renal disease. The nephrotoxicity due to silica is believed to be either due to putative immune complex deposition in the glomeruli or to direct deposition of crystalline material in the interstitium. We report a case in which both of these causative factors were operating at the same time. The patient had glomerular injury due to IgA deposits, accompanied by interstitial damage due to silica deposition. Case Report A 45-year-old Filipino male was admitted to Asir Central Hospital for bilateral leg swelling of three months' duration. He was a tunnel construction worker and was known to have had silicosis of the lungs for several years. The patient reported no history of hematuria, sore throat, skin rash, arthralgia, hypertension or diabetes. There was no history of renal disease in his family. On physical examination, he looked well, the heart rate was 80/min. and blood pressure was 160/100 mm Hg. There was a pitting edema of the leg (++). The conjunctivae were congested but there was no evidence of jaundice, cyanosis or fingernail clubbing. On auscultation of the chest, diffuse bilateral crepitations were heard, mainly in the lower zones. The first heart sound (S ) was normal but the second (S ) was loud. Abdominal and neurological examinations were within normal limits.

58. Health Library - IgA Nephropathy
    iga nephropathy. Synonyms Disorder Subdivisions General Discussion Resources iga nephropathyis a kidney disorder occuring during childhood and young adulthood.  
    http://www.laurushealth.com/Library/HealthGuide/IllnessConditions/topic.asp?hwid

59. Re: Iga Nephropathy And Fish Oils
    kidney patient guide. Re iga nephropathy and fish oils. In Reply to iga nephropathyand fish oils posted by JOANNE on 02 March, 2003 at 071220  
    http://www.kidneypatientguide.org.uk/site/messages/9935.html
    
    Extractions: Follow Ups Post Followup Kidney Patient Guide Bulletin Board Posted by Pierre on 02 March, 2003 at 08:12:53: In Reply to: iga nephropathy and fish oils posted by JOANNE on 02 March, 2003 at 07:12:20: I don't know about those, but have you tried the local pharmacy? They usually have fish oil. Lots of online places too.

60. Iga Nephropathy And Fish Oils
    kidney patient guide. iga nephropathy and fish oils. SINCERELY, JOANNE. Follow UpsRe iga nephropathy and fish oils Pierre 02/3/2003 (0) Post a Followup Name  
    http://www.kidneypatientguide.org.uk/site/messages/9934.html

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